Genetic and metabolic effects on skeletal muscle AMPK in young and older twins

scientific article published on 11 August 2009

Genetic and metabolic effects on skeletal muscle AMPK in young and older twins is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00058.2009
P698PubMed publication ID19671840
P5875ResearchGate publication ID26733348

P50authorRasmus Ribel-MadsenQ42128525
Martin FriedrichsenQ51312930
Jesper B BirkQ54993907
Jørgen WojtaszewskiQ57339852
P2093author name stringAllan Vaag
Pernille Poulsen
Brynjulf Mortensen
Rasmus Ribel-Madsen
Lise Wegner
Kirstine L Stender-Petersen
P2860cites workRole of AMP-activated protein kinase in mechanism of metformin actionQ22241898
AMP-Activated Protein Kinase in Metabolic Control and Insulin SignalingQ22241925
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivationQ24541475
Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscleQ24651012
5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscleQ28208928
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultationQ29547453
Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscleQ33299468
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response studyQ33747784
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscleQ33869428
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscleQ33902357
Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanismQ33907237
AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetesQ34268235
Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscleQ34269935
5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscleQ34276280
Effect of Obesity on Insulin Resistance in Normal Subjects and Patients With NIDDMQ34303806
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.Q34522920
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanismQ34525699
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesisQ35830162
Mechanisms of Insulin Resistance in AgingQ36989263
Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and femalesQ42165751
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscleQ42516404
Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's diseaseQ44030427
AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscleQ44176909
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscleQ44253307
Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twinsQ44253811
AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese femalesQ45050639
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.Q45161288
Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twinsQ45199185
5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes.Q45271639
Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twinsQ46458703
Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exerciseQ46817331
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of trainingQ46849837
The intrauterine environment as reflected by birth size and twin and zygosity status influences insulin action and intracellular glucose metabolism in an age- or time-dependent mannerQ47335926
Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles.Q53668959
Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus.Q54299084
Exercise training induces transitions of myosin isoform subunits within histochemically typed human muscle fibres.Q55060889
Thyroid hormone regulation of myosin heavy chain isoform composition in young and old rats, with special reference to IIX myosinQ57973347
Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exerciseQ58172137
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)E956-64
P577publication date2009-08-11
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleGenetic and metabolic effects on skeletal muscle AMPK in young and older twins
P478volume297

Reverse relations

cites work (P2860)
Q33822976AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle
Q36628896AMPK and Exercise: Glucose Uptake and Insulin Sensitivity.
Q47239465Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle.
Q57458558Exercise training reduces the insulin-sensitizing effect of acute exercise in human skeletal muscle
Q54250681Greater basal skeletal muscle AMPKα phosphorylation in men than in women: Associations with anaerobic performance.
Q40238209High-fat diet differentially regulates metabolic parameters in obesity-resistant S5B/Pl rats and obesity-prone Osborne-Mendel rats
Q55068293Human muscle fibre type-specific regulation of AMPK and downstream targets by exercise.
Q38308538Influence of age on leptin induced skeletal muscle signalling
Q33636870PPARbeta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle.
Q36781795Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise.
Q51553127The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle.
Q33844350The effects of age and muscle contraction on AMPK activity and heterotrimer composition
Q47993217Twin Conception in Sheep Leads to Impaired Insulin Sensitivity and Sexually Dimorphic Adipose Tissue and Skeletal Muscle Phenotypes in Adulthood
Q28485110Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice