TNF-α is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection

scientific article published on 6 May 2010

TNF-α is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1165/RCMB.2009-0323OC
P932PMC publication ID3049236
P698PubMed publication ID20448050

P2093author name stringYong Sung Park
Kwang Chul Kim
Takeshi Koga
Allison Treloar
Seongwon Choi
P2860cites workMUC1, the renaissance moleculeQ28215731
MUC1 expression by human airway epithelial cells mediates Pseudomonas aeruginosa adhesionQ30417890
Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5.Q30447044
Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.Q35781348
Innate immune response in CF airway epithelia: hyperinflammatory?Q36529532
Lipid mediators as agonists for the resolution of acute lung inflammation and injuryQ36600802
COPD as a disease of accelerated lung agingQ37366212
Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell lineQ39886148
MUC1 mucin is a negative regulator of toll-like receptor signalingQ40035539
The signaling pathway involved in neutrophil elastase stimulated MUC1 transcriptionQ40113809
Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signalingQ40116343
TNF-alpha induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implicationQ40118665
Infections caused by Pseudomonas aeruginosaQ40207100
Tumor-derived MUC1 mucins interact with differentiating monocytes and induce IL-10highIL-12low regulatory dendritic cellQ40547474
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 sheddingQ40688718
Identification of MUC1 proteolytic cleavage sites in vivoQ40807638
Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cellsQ44325026
Role of the type 1 TNF receptor in lung inflammation after inhalation of endotoxin or Pseudomonas aeruginosa.Q44451030
Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stressQ44491455
Mutagenesis of a Gly-Ser cleavage site in MUC1 inhibits ectodomain sheddingQ44533998
Pseudomonas aeruginosa stimulates phosphorylation of the airway epithelial membrane glycoprotein Muc1 and activates MAP kinaseQ44953860
Neutrophil elastase stimulates MUC1 gene expression through increased Sp1 binding to the MUC1 promoterQ46453479
MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiationQ47281356
Delayed mammary tumor progression in Muc-1 null mice.Q53459080
Pro-inflammatory Cytokines Up-regulate MUC1 Gene Expression in Oral Epithelial CellsQ59790040
The product of the human MUC1 gene when secreted by mouse cells transfected with the full-length cDNA lacks the cytoplasmic tailQ68144941
IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophilsQ71738139
Muc1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosaQ73335460
KL-6, a human MUC1 mucin, is chemotactic for human fibroblastsQ73893704
Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alphaQ74720767
The protective effect of fermented milk kefir on radiation-induced apoptosis in colonic crypt cells of ratsQ78755624
CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophagesQ79718051
Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout miceQ82878741
P433issue2
P921main subjectPseudomonas aeruginosaQ31856
inflammationQ101991
TNF inhibitorQ1536078
P304page(s)255-260
P577publication date2010-05-06
P1433published inAmerican Journal of Respiratory Cell and Molecular BiologyQ4744268
P1476titleTNF-α is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection
P478volume44

Reverse relations

cites work (P2860)
Q46081731Airborne particulate matter increases MUC5AC expression by downregulating Claudin-1 expression in human airway cells.
Q35813909Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae
Q38085109Cellular and molecular biology of airway mucins
Q36507477Changes in Expression of Genes Regulating Airway Inflammation Following a High-Fat Mixed Meal in Asthmatics.
Q36334400Correlation between p65 and TNF-α in patients with acute myelocytic leukemia
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Q36653456Higher susceptibility to experimental autoimmune encephalomyelitis in Muc1-deficient mice is associated with increased Th1/Th17 responses
Q40538839Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung.
Q35566398Innate immune responses to Pseudomonas aeruginosa infection.
Q37844340Innate immunity in the respiratory epithelium.
Q58580439MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells
Q34212005MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation
Q34305599MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN-β (TRIF) recruitment to Toll-like receptor 3.
Q39182659MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas
Q47696532MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function
Q33880143MUC1: a multifaceted oncoprotein with a key role in cancer progression
Q30353324Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages.
Q39411267Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.
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Q39407900PPARγ inhibits airway epithelial cell inflammatory response through a MUC1-dependent mechanism
Q36164674Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection
Q40087120Pseudomonas aeruginosa increases MUC1 expression in macrophages through the TLR4-p38 pathway
Q36581777Pseudomonas aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation
Q36974529Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein
Q26829473Role of epithelial mucins during airway infection
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Q38921566Silencing of MUC8 by siRNA increases P2Y₂-induced airway inflammation
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Q36309498Suppression of IL-8 production in gastric epithelial cells by MUC1 mucin and peroxisome proliferator-associated receptor-γ.
Q39072349Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells

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