NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction

scientific article published on July 2005

NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1463-1326.2004.00393.X
P698PubMed publication ID15955119

P2093author name stringHayashi T
Iguchi A
Fukatsu A
Tsunekawa T
Matsui-Hirai H
Sumi D
Dingqunfang D
Juliet PA
Kano-Hayashi H
P2860cites workAssociation of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational studyQ22242096
Mechanisms underlying endothelial dysfunction in diabetes mellitusQ31829307
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterinQ32129593
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactorsQ36253833
Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and veinQ38274417
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiencyQ42090666
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alphaQ42162100
Proliferation of airway epithelium after ozone exposure: effect of apocynin and dexamethasoneQ42544207
Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteriesQ44139534
Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats.Q44195920
Oxygen radicals in exsanguination-induced bronchoconstriction of guinea pigsQ46378954
Identification of a functional leukocyte-type NADPH oxidase in human endothelial cells :a potential atherogenic source of reactive oxygen species.Q52537342
P433issue4
P921main subjectendotheliumQ111140
type 2 diabetesQ3025883
P304page(s)334-343
P577publication date2005-07-01
P1433published inDiabetes, Obesity and MetabolismQ5270109
P1476titleNADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction
P478volume7

Reverse relations

cites work (P2860)
Q282378064-Hydr-oxy-3-meth-oxy-5-nitro-aceto-phenone (5-nitro-apocynin)
Q34009599Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities
Q38568053Animal models of erectile dysfunction
Q34595226Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice
Q28571677Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension
Q45962507Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats.
Q88768230Endothelium-dependent vasodilation in the cerebral arterioles of rats deteriorates during acute hyperglycemia and then is restored by reducing the glucose level
Q42866892Gender Differences in Vascular Reactivity of Aortas from Streptozotocin-Induced Diabetic Mice
Q57359108High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: Implications for atherosclerosis
Q37185110Impaired vascular KATP function attenuates exercise capacity in obese zucker rats
Q35668062Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice
Q41349377Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease.
Q37088271NADPH oxidase has a directional response to shear stress
Q37214226Nicotinamide adenine dinucleotide phosphate oxidase and diabetes: vascular implications
Q38188467Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement
Q35779691Oxidative Stress-Dependent Coronary Endothelial Dysfunction in Obese Mice
Q37274266Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow
Q33917051Physical activity maintains aortic endothelium-dependent relaxation in the obese type 2 diabetic OLETF rat
Q47937992Protective Role of Apocynin via Suppression of Neuronal Autophagy and TLR4/NF-κB Signaling Pathway in a Rat Model of Traumatic Brain Injury
Q36629849Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase.
Q59279106Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes
Q58075704Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Q28080903Traumatic brain injury and NADPH oxidase: a deep relationship

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