cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1

scientific article published on July 12, 2011

cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00652.2010
P953full work available at URLhttps://www.physiology.org/doi/pdf/10.1152/ajpendo.00652.2010
P698PubMed publication ID21750265
P5875ResearchGate publication ID51486755

P50authorHervé Le StunffQ88669525
P2093author name stringMarie-Hélène Giroix
Bernard Portha
Jamileh Movassat
Magali Fradet
Danielle Bailbé
Micheline Kergoat
Manuel Dolz
P2860cites workCritical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretionQ28510313
cAMP-GEFII is a direct target of cAMP in regulated exocytosisQ28512994
Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulinQ28565526
Glucose enhances adenylyl cyclase responses in normal but not diabetic GK rat isletsQ31804728
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cellsQ33231962
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosisQ34453808
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.Q35162237
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell lineQ36430259
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cellsQ36843192
The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes?Q37221610
Regulation of insulin secretion: a matter of phase control and amplitude modulationQ37415411
Islet structure and function in the GK rat.Q37706252
Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetesQ38338987
The Adenylate cyclase-cyclic AMP system in islets of langerhans and its role in the control of insulin releaseQ39257121
The role of cyclic AMP in insulin releaseQ40078293
Decreased ADP-ribosylation of the Galpha(olf) and Galpha(s) subunits by high glucose in pancreatic B-cellsQ40884520
The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretionQ40938618
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilizationQ41328714
Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studiesQ42448737
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).Q42574446
Overexpression of Gs proteins and adenylyl cyclase in normal and diabetic isletsQ44079879
PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence for generation of cAMP compartments uncoupled from hormone release in diabetic isletsQ44397753
Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretionQ46550423
Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP productionQ46774736
Glucagon-Like Peptide 1(7-36) Amide Stimulates Exocytosis in Human Pancreatic -Cells by Both Proximal and Distal Regulatory Steps in Stimulus-Secretion CouplingQ58448979
Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptorsQ60032499
Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activityQ70492604
Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMPQ71150182
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIPQ71738070
The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release LIII. Calcium-Dependency of the Cyclic AMP Response to Nutrient SecretagoguesQ72689662
Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptideQ73167345
Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat isletsQ73679210
Galphaolf identification by RT-PCR in purified normal pancreatic B cells and in islets from rat models of non-insulin-dependent diabetesQ77911690
Diabetic GK/Par rat beta-cells are spontaneously protected against H2O2-triggered apoptosis. A cAMP-dependent adaptive responseQ84754697
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)E797-806
P577publication date2011-07-12
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titlecAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1
P478volume301

Reverse relations

cites work (P2860)
Q35055522Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass
Q27008275Cyclic AMP dynamics in the pancreatic β-cell
Q93110126FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells
Q43520012Metabolic Disturbances and Defects in Insulin Secretion in Rats With Streptozotocin-Nicotinamide-Induced Diabetes
Q38224884New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice
Q41518152Optogenetic regulation of insulin secretion in pancreatic β-cells
Q36978302SAD-A Potentiates Glucose-Stimulated Insulin Secretion as a Mediator of Glucagon-Like Peptide 1 Response in Pancreatic β Cells
Q34255921The use of animal models in diabetes research
Q28589308Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

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