A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer

scientific article

A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YGYNO.2016.04.019
P698PubMed publication ID27103175

P50authorKeiichi FujiwaraQ92525856
P2093author name stringAntonio González-Martín
Michael Birrer
Martin Gore
Amit Oza
Kei Muro
Susie Lau
Craig Davis
Brett Houk
Andres Poveda
Carolyn Muller
Mie Suzuki
Jennifer Vermette
Ashwin Gollerkeri
Josep María Del Campo
Kristen Pierce
P2860cites workPhase I study of PF-04691502, a small-molecule, oral, dual inhibitor of PI3K and mTOR, in patients with advanced cancer.Q51329014
Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancerQ83223369
Mutational analysis of gene families in human cancerQ29038888
Phosphoinositide kinasesQ29618047
Novel agents and associated toxicities of inhibitors of the pi3k/Akt/mtor pathway for the treatment of breast cancerQ35072441
First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer.Q35868423
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activationQ37140110
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancerQ37187915
Mammalian target of rapamycin (mTOR) inhibitor-associated non-infectious pneumonitis in patients with renal cell cancer: predictors, management, and outcomesQ37621799
Emerging therapeutic targets in endometrial cancerQ37827340
New strategies in endometrial cancer: targeting the PI3K/mTOR pathway--the devil is in the detailsQ38148744
Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinomaQ38388678
PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activityQ39507948
Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitorQ39591379
Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: incidence, radiographic findings and correlation with clinical outcomeQ44166101
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)62-69
P577publication date2016-04-18
P1433published inGynecologic OncologyQ5625182
P1476titleA randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer
P478volume142

Reverse relations

cites work (P2860)
Q47130538A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer
Q48138303Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.
Q91760324Distribution, Metabolism, and Excretion of Gedatolisib in Healthy Male Volunteers After a Single Intravenous Infusion
Q46764265Evaluation of endometrial carcinoma prognostic immunohistochemistry markers in the context of molecular classification
Q33438286First-in-human trial of an anti-5T4 antibody-monomethylauristatin conjugate, PF-06263507, in patients with advanced solid tumors
Q89599313Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?
Q90444254Modulator of the PI3K/Akt oncogenic pathway affects mTOR complex 2 in human adenocarcinoma cells
Q92276603Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway
Q98164379Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
Q64254413Targeting PI3K in cancer: mechanisms and advances in clinical trials
Q99549077Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence
Q91814537Targeting mTOR and Metabolism in Cancer: Lessons and Innovations
Q91660586Targeting mTOR for cancer therapy
Q38982579mTORC1 and mTORC2 in cancer and the tumor microenvironment

Search more.