Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage.

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Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage. is …
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scholarly articleQ13442814

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P356DOI10.1681/ASN.2015080910
P932PMC publication ID5280004
P698PubMed publication ID27436852

P50authorSandra Rayego-MateosQ59704892
Ana B SanzQ63413139
Raul Rodrigues-DiezQ87951751
Pierre-Louis TharauxQ48189014
Carlos López-LarreaQ51888859
Marta Ruiz-OrtegaQ56616783
P2093author name stringAlberto Ortiz
Jesus Egido
Pablo Cannata-Ortiz
Beatriz Suarez-Alvarez
Ramon M Rodriguez
José Luis Morgado-Pascual
P2860cites workBrd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelAQ24293271
Selective inhibition of BET bromodomainsQ24301009
Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progressionQ24301464
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelAQ24310313
Histone recognition and large-scale structural analysis of the human bromodomain familyQ24310431
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcriptionQ24316236
Suppression of inflammation by a synthetic histone mimicQ27665789
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaQ27674674
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domainQ28116760
The mechanisms behind the therapeutic activity of BET bromodomain inhibitionQ28241504
BET bromodomain inhibition as a therapeutic strategy to target c-MycQ28247024
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4Q28267929
lumi: a pipeline for processing Illumina microarrayQ29614924
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaQ29617201
Selective inhibition of tumor oncogenes by disruption of super-enhancersQ29617301
Gene activation by histone and factor acetyltransferasesQ33680840
DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney diseaseQ33740666
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemiaQ33864145
Role of BRD4 in hematopoietic differentiation of embryonic stem cells.Q34000419
Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitorsQ34295282
BET bromodomains mediate transcriptional pause release in heart failureQ34361491
BET bromodomain inhibition suppresses TH17-mediated pathologyQ34375887
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulationQ34388531
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancerQ34416771
Epigenetics in kidney development and renal diseaseQ34633331
RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cellsQ34831560
An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinomaQ34926232
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.Q35096586
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritisQ35404631
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.Q35766387
Recent developments in epigenetics of acute and chronic kidney diseasesQ35909055
BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.Q36718203
Induction and effector functions of T(H)17 cells.Q37194494
Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammationQ37269787
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancerQ37338486
Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signalingQ37388856
Beyond genetics: epigenetic code in chronic kidney diseaseQ37402757
Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction.Q37553560
NF-kappaB in renal inflammationQ37774798
The emergence of TH17 cells as effectors of renal injury.Q37834852
Chemokines in renal injury.Q37862893
Unilateral ureteral obstruction: beyond obstruction.Q38144939
Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases.Q38165621
TNF receptors: signaling pathways and contribution to renal dysfunctionQ38241605
Interleukin-17 and innate immunity in infections and chronic inflammationQ38496581
Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidenceQ38542092
Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritisQ39238937
Differential regulation of NF-kappaB by elongation factors is determined by core promoter typeQ40133041
Effect of simultaneous blockade of AT1 and AT2 receptors on the NFkappaB pathway and renal inflammatory response.Q40562942
Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritisQ40817673
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.Q41641646
Brd4 is on the move during inflammationQ41773632
NF-κB directs dynamic super enhancer formation in inflammation and atherogenesisQ41971115
BET acetyl-lysine binding proteins control pathological cardiac hypertrophyQ42709887
Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosisQ42710737
Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cellsQ42831103
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.Q43730164
Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction.Q44903329
Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation.Q44963993
The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.Q48248907
The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response.Q51016267
P4510describes a project that useslimmaQ112236343
P433issue2
P304page(s)504-519
P577publication date2016-07-19
P1433published inJournal of the American Society of NephrologyQ17123893
P1476titleInhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage
P478volume28

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Q39442981BRD4 inhibition for the treatment of pathological organ fibrosis
Q55316265Benefit of Apabetalone on Plasma Proteins in Renal Disease.
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Q60054289Bromodomain protein inhibition: a novel therapeutic strategy in rheumatic diseases
Q92253374Bromodomain-containing protein 4 contributes to renal fibrosis through the induction of epithelial-mesenchymal transition
Q33751386Chemical probes targeting epigenetic proteins: Applications beyond oncology
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Q54111513Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis.
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Q44011765Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells.
Q89723568Targeting the progression of chronic kidney disease
Q92062125The Contribution of Histone Crotonylation to Tissue Health and Disease: Focus on Kidney Health

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