IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation.

scientific article

IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1700127
P698PubMed publication ID28724580

P50authorJulie DemaretQ57417362
François MalletQ60614082
Julien TextorisQ37839662
Fabienne VenetQ38545407
P2093author name stringAlain Lepape
Guillaume Monneret
Benjamin J Blaise
Thomas Rimmelé
Christelle Rouget
Thibaut Girardot
Estellie Idealisoa
P2860cites workDefinitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care MedicineQ22306067
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Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis.Q34535214
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Persistent lymphopenia after diagnosis of sepsis predicts mortality.Q35184876
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidationQ35311785
Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients.Q35559497
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Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal deathQ36068891
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Regulation of immune responses by mTOR.Q37963950
Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis patternQ37977528
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Lactic Acidosis in Sepsis: It's Not All Anaerobic: Implications for Diagnosis and ManagementQ38588390
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Emerging concepts of T cell metabolism as a target of immunotherapy.Q40745622
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsisQ40765104
Metabolic dysfunction in lymphocytes promotes postoperative morbidity.Q41311165
STAT5 phosphorylation in T cell subsets from septic patients in response to recombinant human interleukin-7: a pilot studyQ41477931
Decreased T-cell repertoire diversity in sepsis: a preliminary studyQ43514997
IL-7 enhances the survival and maintains the size of naive T cellsQ43819910
SRV: an open-source toolbox to accelerate the recovery of metabolic biomarkers and correlations from metabolic phenotyping datasetsQ45743470
Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock.Q50741264
Statistical recoupling prior to significance testing in nuclear magnetic resonance based metabonomics.Q51813891
Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007.Q53089518
Forward light scatter is a simple measure of T-cell activation and proliferation but is not universally suited for doublet discrimination.Q53238934
Early assessment of leukocyte alterations at diagnosis of septic shock.Q54437566
Orthogonal projections to latent structures (O-PLS)Q56435041
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectsepsisQ183134
lymphocyteQ715347
septic shockQ1765564
P304page(s)1606-1615
P577publication date2017-07-19
P1433published inJournal of ImmunologyQ3521441
P1476titleIL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation
P478volume199

Reverse relations

cites work (P2860)
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Q92703579mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease

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