Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension

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Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1050893047
P356DOI10.1038/SJ.GT.3301633
P698PubMed publication ID11857069
P5875ResearchGate publication ID11504908

P50authorAnna DominiczakQ4766963
P2093author name stringBaker AH
Nicklin SA
Heistad DD
Hamilton CA
Alexander MY
Brosnan MJ
Fennell JP
Frater AJ
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Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertensionQ28368985
Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbitsQ28372419
Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarctionQ30417743
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterinQ32129593
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Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vectorQ35068584
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Lower intracellular hydrogen peroxide levels in cells overexpressing CuZn-superoxide dismutaseQ36163220
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Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosisQ39801237
Delivery of Cu/Zn-superoxide dismutase genes with a viral vector minimizes liver injury and improves survival after liver transplantation in the rat.Q40770000
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Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbitsQ41169284
Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat modelQ42484128
Gene transfer of endothelial nitric oxide synthase but not Cu/Zn superoxide dismutase restores nitric oxide availability in the SHRSP.Q42492596
Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aortaQ43610486
Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in the absence but not in the presence of atherosclerotic plaqueQ43695940
Abnormal endothelium-dependent vascular relaxation in patients with essential hypertensionQ43789338
Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells.Q43827486
Gene therapy with extracellular superoxide dismutase attenuates myocardial stunning in conscious rabbitsQ45889458
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Sex differences in the abundance of endothelial nitric oxide in a model of genetic hypertension.Q50918299
Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.Q54130783
Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension.Q54240967
Recombinant human superoxide dismutases: production and potential therapeutical uses.Q54701999
Simple Methods for Preparing Recombinant Adenoviruses for High-Efficiency Transduction of Vascular CellsQ58227797
Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of AtherosclerosisQ63365783
Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunctionQ64380969
Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosisQ64382030
Decreased basal despite enhanced agonist-stimulated effects of nitric oxide in 12-week-old stroke-prone spontaneously hypertensive rat.Q64937951
Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in manQ69375610
Effect of copper-zinc superoxide dismutase on endothelium-dependent vasodilation in patients with essential hypertensionQ71565330
The Interstitium of the Human Arterial Wall Contains Very Large Amounts of Extracellular Superoxide DismutaseQ71799276
The role of O2.- in the production of HO.: in vitro and in vivoQ72754187
Pharmacokinetics of extracellular-superoxide dismutase in the vascular systemQ72946338
P433issue2
P921main subjectarterial hypertensionQ41861
endotheliumQ111140
AdenoviridaeQ193447
overexpressionQ61643320
P304page(s)110-117
P577publication date2002-01-01
P1433published inGene TherapyQ15763095
P1476titleAdenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension
P478volume9

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