Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat.

scientific article

Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.1996.271.4.E755
P8608Fatcat IDrelease_nc5xiiizzvhd5jkdus65brfysu
P698PubMed publication ID8897865

P2093author name stringPortha B
Berthelier C
Bailbé D
Picarel-Blanchot F
P2860cites workCorrection of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic ratsQ24563606
Impaired skeletal muscle glycogen synthase activation by insulin in the Goto-Kakizaki (G/K) rat.Q30465190
Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic beta cell in rats.Q34189030
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed ratsQ34975588
Natural history of beta-cell dysfunction in NIDDM.Q37977228
Hormonal responses and future treatment of non-insulin-dependent diabetes mellitus (NIDDM).Q40711404
Glucose Insensitivity and Amino-acid Hypersensitivity of Insulin Release in Rats with Non-insulin-dependent Diabetes: A Study with the Perfused PancreasQ42454625
Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetesQ42475849
Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozocin as neonatesQ42492204
Time courses of changes in hepatic and skeletal muscle insulin action and GLUT4 protein in skeletal muscle after STZ injection.Q45968830
Development of decreased insulin-induced glucose transport in skeletal muscle of glucose-intolerant hybrids of diabetic GK rats.Q51590437
The role of islet secretory function in the development of diabetes in the GK Wistar rat.Q51594144
Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.Q51597853
Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment.Q54318715
P433issue4 Pt 1
P407language of work or nameEnglishQ1860
P921main subjectglycobiologyQ899224
glucoseQ37525
P304page(s)E755-62
P577publication date1996-10-01
P1433published inAmerican Journal of PhysiologyQ2160146
P1476titleImpaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat.
P478volume271

Reverse relations

cites work (P2860)
Q37650212A review of rodent models of type 2 diabetic skeletal fragility
Q51666922Abnormalities in the Metabolism of Fatty Acids and Triacylglycerols in the Liver of the Goto-Kakizaki Rat: A Model for Non-Obese Type 2 Diabetes.
Q41810412Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus
Q36989976Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.
Q37728938Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology
Q37210501Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats
Q47127780Comparison of Goto-Kakizaki rats and high fat diet-induced obese rats: Are they reliable models to study Type 2 Diabetes mellitus?
Q37368852Comparison of the Development Diabetic Induced Renal Disease in Strains of Goto-Kakizaki Rats
Q26799371Current status and patent prospective of animal models in diabetic research
Q61450889Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats
Q28066824Experimental Diabetes Mellitus in Different Animal Models
Q45145875Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration
Q37310711IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
Q37378354Impaired pancreatic beta cell function in the fetal GK rat. Impact of diabetic inheritance
Q29347083Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats
Q33494724MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes
Q34051199Nutrient toxicity in pancreatic beta-cell dysfunction
Q64258818Profound Changes in Net Energy and Nitrogen Metabolites Fluxes within the Splanchnic Area during Overfeeding of Yucatan Mini Pigs That Remain Euglycemic
Q33597948Proteome, phosphoproteome, and hydroxyproteome of liver mitochondria in diabetic rats at early pathogenic stages
Q36182573Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling
Q37291322RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat.
Q37407878Rat models for bariatric surgery and surgery for type 2 diabetes mellitus
Q37000175Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes
Q92857387Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats
Q36825754Spontaneous type 2 diabetic rodent models
Q36741947Transcriptome Profiles Using Next-Generation Sequencing Reveal Liver Changes in the Early Stage of Diabetes in Tree Shrew (Tupaia belangeri chinensis)

Search more.