Interaction between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in Saccharomyces cerevisiae

scientific article published on February 1999

Interaction between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1460500
P698PubMed publication ID9927443

P2093author name stringE A Vallen
F R Cross
P2860cites workReconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNAQ24322818
DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombeQ24555694
The Schizosaccharomyces pombe rad3 checkpoint geneQ24561779
The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homologQ24564017
Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpointQ24564395
Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclinsQ24564654
Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiaeQ24598237
DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiaeQ24627252
Rnr4p, a novel ribonucleotide reductase small-subunit proteinQ27930465
Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiaeQ27933444
SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.Q27935086
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repairQ27935229
The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiaeQ27939221
CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiaeQ27939590
Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertaseQ28131607
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coliQ28131613
Checkpoints: controls that ensure the order of cell cycle eventsQ28131705
Cell cycle checkpoints: preventing an identity crisisQ29547644
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathwaysQ29615271
CLB5: a novel B cyclin from budding yeast with a role in S phaseQ29618258
An essential G1 function for cyclin-like proteins in yeastQ29620232
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpointQ29620700
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeastQ29620732
Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathwayQ30663148
Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpointsQ33190942
A Tn10-lacZ-kanR-URA3 gene fusion transposon for insertion mutagenesis and fusion analysis of yeast and bacterial genesQ33953078
RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.Q33969321
Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formationQ34065716
A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycleQ34110710
CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cellsQ34297965
G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycleQ34323450
Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viabilityQ36447249
Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonateQ36922800
The regulation of histone synthesis in the cell cycleQ37285335
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.Q37380779
Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeastQ37484461
Simple and complex cell cyclesQ38368830
Mutations in RAD27 define a potential link between G1 cyclins and DNA replicationQ40016855
Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificitiesQ40020425
Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathwayQ40023543
Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeastQ40874618
Starting the cell cycle: what's the point?Q40974438
Ribonucleotide reductase activity during the cell cycle of Saccharomyces cerevisiaeQ43745412
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductaseQ45078328
Different G1 cyclins control the timing of cell cycle commitment in mother and daughter cells of the budding yeast S. cerevisiaeQ46483721
Control of the timing of cell division in fission yeast. Cell size mutants reveal a second control pathwayQ47316355
TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia geneQ48070727
Negative regulation of FAR1 at the Start of the yeast cell cycle.Q51054650
Linkage of replication to start by the Cdk inhibitor Sic1.Q51114804
'Marker swap' plasmids: convenient tools for budding yeast molecular genetics.Q52526054
Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathwaysQ58883742
The CDC8 transcript is cell cycle regulated in yeast and is expressed coordinately with CDC9 and CDC21 at a point preceding histone transcriptionQ68181215
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1Q71709839
Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functionsQ73041323
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P1104number of pages13
P304page(s)459-471
P577publication date1999-02-01
P1433published inGeneticsQ3100575
P1476titleInteraction between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in Saccharomyces cerevisiae
P478volume151

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cites work (P2860)
Q38932741A common strategy for initiating the transition from proliferation to quiescence
Q21203553An overview of Cdk1-controlled targets and processes
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Q35633411Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase
Q41762335Functional distinction between Cln1p and Cln2p cyclins in the control of the Saccharomyces cerevisiae mitotic cycle.
Q42072745G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint
Q35293714Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
Q27933460Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae
Q26864428Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae
Q36043956Msa1 and Msa2 Modulate G1-Specific Transcription to Promote G1 Arrest and the Transition to Quiescence in Budding Yeast
Q28354208Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase
Q27930735NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae
Q34614084Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability.
Q42153672S-phase cyclin-dependent kinases promote sister chromatid cohesion in budding yeast.
Q39354553Testing a mathematical model of the yeast cell cycle
Q28343318The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
Q27938875Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state