Development of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina

scientific article published on June 1990

Development of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.1990.TB15803.X
P932PMC publication ID1917440
P698PubMed publication ID2379037
P5875ResearchGate publication ID20777128

P2093author name stringShah MA
Neal MJ
P2860cites workThe action of gamma-vinyl-GABA and gamma-acetylenic-GABA on the resting and stimulated release of GABA in vivoQ71207668
gamma-Aminobutyric acid metabolism in rat brain following chronic oral administration of ethanolamine O-sulphateQ71259408
Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid)Q71559140
Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in miceQ71604447
The distribution of glutamic-gamma-aminobutric transaminase in the nervous system of the rhesus monkeyQ78655205
4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brainQ28331377
Double-blind study of gamma-vinyl GABA in patients with refractory epilepsyQ34054805
Efficacy and safety of vigabatrin in the long-term treatment of refractory epilepsyQ34396923
Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, ?-acetylenic GABA (4-amino-hex-5-ynoic acid) and ?-vinyl GABA (4-amino-hex-5-enoic acid)Q39625389
On the mechanism by which veratridine causes a calcium-independent release of gamma-aminobutyric acid from brain slicesQ39929449
Effect of electrical stimulation and high potassium concentrations on the effux of (14C) glycine from slices of spinal cordQ40017837
Baclofen and phaclofen modulate GABA release from slices of rat cerebral cortex and spinal cord but not from retinaQ42847554
Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neuronsQ48106989
One to three day dose intervals during subchronic treatment of epileptic gerbils with gamma-vinyl GABA: anticonvulsant efficacy and alterations in regional brain GABA levelsQ48182897
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbilsQ48362163
Stimulated release of endogenous GABA and glycine from the goldfish retinaQ48445018
Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acidQ48858993
Subcellular distribution of endogenous and (3H) gamma-aminobutyric acid in rat cerebral cortexQ48987498
The fluorometric measurement of glutamic decarboxylase and its distribution in brain.Q51318976
Immunocytochemical evidence that vigabatrin in rats causes GABA accumulation in glial cells of the retinaQ69592066
Effects of anticonvulsants on the in vivo and in vitro release of GABAQ70719551
Biochemical and clinical effects of gamma-vinyl GABA in patients with epilepsyQ70789166
Gamma-vinyl-GABA: a single-blind trial in patients with epilepsyQ71018771
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)324-328
P577publication date1990-06-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleDevelopment of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina
P478volume100

Reverse relations

cites work (P2860)
Q57098730Activity-dependent γ-aminobutyric acid release controls brain cortical tissue slice metabolism
Q54231363Adjuvant vigabatrin in refractory epilepsy: a ceiling to effective dosage in individual patients?
Q33982061Characteristic retinal atrophy with secondary "inverse" optic atrophy identifies vigabatrin toxicity in children
Q28378109Characteristics of a unique visual field defect attributed to vigabatrin
Q28564804Detection of reduced GABA synthesis following inhibition of GABA transaminase using in vivo magnetic resonance signal of [13C]GABA C1
Q41772520Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats
Q48158635Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma
Q44009053Effects of gamma-vinyl GABA (vigabatrin) on blood pressure and body weight of hypertensive and normotensive rats
Q48340498Effects of increased gamma-aminobutyric acid levels on GAD67 protein and mRNA levels in rat cerebral cortex
Q41891059Effects of single and multiple increasing doses of vigabatrin on brain gaba metabolism and correlation with vigabatrin plasma concentration
Q32027616Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics
Q42713628Effects of zaprinast and rolipram on platelet aggregation and arrhythmias following myocardial ischaemia and reperfusion in anaesthetized rabbits
Q35590459Epilepsy patients treated with vigabatrin exhibit reduced ocular blood flow
Q34559174Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs
Q41649696GABA(A) receptors mediate inhibition of T cell responses.
Q43183029Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy
Q30768157In vivo monitoring of rat brain metabolites during vigabatrin treatment using localized 2D-COSY.
Q43463173Increased intracellular gamma-aminobutyric acid selectively lowers the level of the larger of two glutamate decarboxylase proteins in cultured GABAergic neurons from rat cerebral cortex
Q41767611Longitudinal changes in photopic OPs occurring with vigabatrin treatment
Q32066867Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin
Q34928181Neurotoxic effects of GABA-transaminase inhibitors in the treatment of epilepsy: ocular perfusion and visual performance
Q36747283Nuclear magnetic resonance detection of increased cortical GABA in vigabatrin-treated rats in vivo.
Q41514405Optimizing the indication of vigabatrin in children with refractory epilepsy
Q36586336Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin
Q99634865Proteomics Reveals the Potential Protective Mechanism of Hydrogen Sulfide on Retinal Ganglion Cells in an Ischemia/Reperfusion Injury Animal Model
Q90319435Rational approaches for the design of various GABA modulators and their clinical progression
Q43958757Retinal neurochemical changes following application of glutamate as a metablolic substrate
Q48144592Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex
Q37149913Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity
Q44285965The effects of GABA and vigabatrin on horizontal cell responses to light and the effect of vigabatrin on the electroretinogram
Q48925359The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA).
Q43686221Vigabatrin effect on inner retinal function
Q43774639Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy
Q61848313Vigabatrin reduces epileptiform activity in brain slices from pharmacoresistant epilepsy patients
Q44489274Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina
Q36676442Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control
Q35454439Visual field defects associated with vigabatrin therapy
Q34313490Visual field defects with vigabatrin: epidemiology and therapeutic implications

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