Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis

scientific article published on 12 April 2016

Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3892/MMR.2016.5108
P932PMC publication ID4878538
P698PubMed publication ID27082311

P2093author name stringZhanguo Li
Hua Hu
Min Sun
Zhongwei Tian
Xiangfeng Song
Dandan Fu
P2860cites workVariants inRUNX3Contribute to Susceptibility to Psoriatic Arthritis, Exhibiting Further Common Ground With Ankylosing SpondylitisQ57265156
Genetics: Deep explorationQ59062504
A role for T cell-derived interleukin 22 in psoriatic skin inflammationQ62662121
Role of Th17 cells in human autoimmune arthritisQ84488292
Soluble biomarkers may differentiate psoriasis from psoriatic arthritisQ84508516
Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild to moderate allergic contact dermatitisQ84788962
Psoriasis and metabolic syndromeQ95515670
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesisQ24310469
Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple SclerosisQ26771957
Memory IL-22-producing CD4+ T cells specific for Candida albicans are present in humansQ28245271
The RUNX genes: gain or loss of function in cancerQ28247901
The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasisQ28261494
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gammaQ28590652
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasiaQ28591205
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.Q30419116
IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cellsQ33869215
T cell responses in psoriasis and psoriatic arthritisQ34666667
Plasticity of CD4+ T cell lineage differentiation.Q34982725
Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese femalesQ35088480
Immunopathogenesis and role of T cells in psoriasisQ37005285
Induction and effector functions of T(H)17 cells.Q37194494
Th17 cells: a new paradigm for cutaneous inflammationQ37217449
IL-17 and Th17 cells in human inflammatory diseasesQ37446159
Breaking old paradigms: Th17 cells in autoimmune arthritisQ37464427
Molecular pathology of RUNX3 in human carcinogenesisQ37580103
Th17 and Th22 cells in psoriatic arthritis and psoriasisQ37689670
Regulation of gene expression in peripheral T cells by Runx transcription factorsQ37748069
Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesisQ37830785
Th22 in inflammatory and autoimmune disease: prospects for therapeutic interventionQ37850717
Psoriatic arthritis: genetics and pathogenesisQ38018071
Th17 cells and IL-17 a--focus on immunopathogenesis and immunotherapeuticsQ38155294
Therapeutic potential of STAT4 in autoimmunityQ38213100
The skin in psoriasis: assessment and challengesQ38608664
Overexpression of RUNX3 inhibits malignant behaviour of Eca109 cells in vitro and vivoQ39014369
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammationQ40734155
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencerQ41839885
Investigation of methylation and protein expression of the Runx3 gene in colon carcinogenesisQ41879990
A large-scale screen for coding variants predisposing to psoriasisQ43894399
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.Q45939390
Heritability of psoriasis in a large twin sample.Q45972799
IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not.Q51745791
P433issue6
P304page(s)4606-4612
P577publication date2016-04-12
P1433published inMolecular Medicine ReportsQ26842180
P1476titleDownregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis
P478volume13

Reverse relations

cites work (P2860)
Q55332265A catalog of potential putative functional variants in psoriasis genome-wide association regions.
Q55386458The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis.