Synthesis and g-quadruplex-binding properties of defined acridine oligomers.

scientific article published on 13 June 2010

Synthesis and g-quadruplex-binding properties of defined acridine oligomers. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4061/2010/489060
P932PMC publication ID2915818
P698PubMed publication ID20725626
P5875ResearchGate publication ID44849804

P50authorAna AviñóQ71808633
Ramon EritjaQ42621686
Raimundo GargalloQ48014272
Ricardo Pérez-TomásQ40086267
P2093author name stringRubén Ferreira
P2860cites workCrystal structure of parallel quadruplexes from human telomeric DNAQ22122125
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionQ24535577
Preferential binding of a G-quadruplex ligand to human chromosome ends.Q24815673
Structure of a G-quadruplex-ligand complexQ27640348
Structural basis of DNA quadruplex recognition by an acridine drugQ27650536
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplexQ27730906
Reaching into the Major Groove of B-DNA: Synthesis and Nucleic Acid Binding of a Neomycin−Hoechst 33258 ConjugateQ33193738
Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes.Q33282518
G-quadruplex DNA: a potential target for anti-cancer drug designQ33877249
Secondary DNA structures as molecular targets for cancer therapeuticsQ34439504
Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbonesQ58035332
Targeting the G-quadruplex-forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and with the complementary C-rich strandQ58054850
Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and chargeQ58854655
Sequence and structural selectivity of nucleic acid binding ligandsQ73248196
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferationQ40328181
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.Q40453766
Use of competition dialysis in the discovery of G-quadruplex selective ligands.Q41853653
Design of a sequence-specific DNA bisintercalatorQ46802972
Selection of single-stranded DNA molecules that bind and inhibit human thrombinQ34616171
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solutionQ36914814
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeuticsQ36959489
DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of actionQ36995698
A hitchhiker's guide to G-quadruplex ligandsQ37080928
Hunting G-quadruplexesQ37092590
Recent developments in the chemistry of deoxyribonucleic acid (DNA) intercalators: principles, design, synthesis, applications and trendsQ37496485
Investigating a quadruplex-ligand interaction by unfolding kineticsQ38311198
Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbonesQ40005688
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)913-914
P577publication date2010-06-13
P1433published inJournal of Nucleic AcidsQ26853953
P1476titleSynthesis and g-quadruplex-binding properties of defined acridine oligomers
P478volume2010

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cites work (P2860)
Q64112180Practical Microwave Synthesis of Carbazole Aldehydes for the Development of DNA-Binding Ligands
Q28488110Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines
Q39334155Synthesis, DNA-binding and antiproliferative properties of acridine and 5-methylacridine derivatives

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