tolvaptan

selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone

Wikidata entity: Q426132

C₂₆H₂₅ClN₂O₃ (P274)


Wikimedia Commons category is Tolvaptan



Quantities

P4250defined daily dose30
P2067mass448.155

P3780 active ingredient in ... Q29006062 (Jinarc) Jinarc
P3780 active ingredient in ... Q29006464 (Samsca) Samsca
P233 canonical SMILES String CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C ???
P373 Commons category String Tolvaptan ???
P366 has use ... Q12140 (medication) medication
P31 instance of ... Q113145171 (type of chemical entity) type of chemical entity
P3493 legal status (medicine) ... Q879952 (boxed warning) boxed warning
P2175 medical condition treated ... Q147778 (liver cirrhosis) liver cirrhosis
P2175 medical condition treated ... Q959457 (syndrome of Inappropriate antidiuretic hormone secretion) syndrome of Inappropriate antidiuretic hormone secretion
P2175 medical condition treated ... Q19000661 (congestive heart failure) congestive heart failure
P129 physically interacts with ... Q4789584 (Arginine vasopressin receptor 1A) Arginine vasopressin receptor 1A
P129 physically interacts with ... Q4789588 (Arginine vasopressin receptor 2) Arginine vasopressin receptor 2
P3489 pregnancy category ... Q28123617 (US pregnancy category C) US pregnancy category C
P279 subclass of ... Q11173 (chemical compound) chemical compound
P2868 subject has role ... Q50430477 (antidiuretic hormone receptor antagonists) antidiuretic hormone receptor antagonists

External Ids
P267ATC codeC03XA01
P231CAS Registry Number150683-30-0
P683ChEBI ID32246
P592ChEMBL IDCHEMBL344159
P661ChemSpider ID187438
P9272DeCS ID57705
P11198DrugCentral ID4110
P8494DSSTOX compound identifierDTXCID9028706
P3117DSSTox substance IDDTXSID3048780
P232EC number691-537-5
P2566ECHA Substance Infocard ID100.219.212
P646Freebase ID/m/026ljpf
P595Guide to Pharmacology Ligand ID2226
P2062HSDB ID8196
P4168IEDB Epitope ID1635951
P234InChIInChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
P235InChIKeyGYHCTFXIZSNGJT-UHFFFAOYSA-N
P665KEGG IDD01213
P10245MedlinePlus drug identifiera609033
P10245MedlinePlus drug identifiera620041
P486MeSH descriptor IDD000077602
P672MeSH tree codeD03.633.100.079.875
P6366Microsoft Academic ID (discontinued)2780615674
P2115NDF-RT IDN0000178481
P10283OpenAlex IDC2780615674
P11199Probes And Drugs IDPD010925
P662PubChem CID216237
P3345RxNorm CUI358257
P4964SPLASHsplash10-0udi-0190200000-4b2ed1c8a21521622f4e
P2877SureChEMBL ID242421
P2892UMLS CUIC0762110
P2892UMLS CUIC1176308
P11089UniChem compound ID115730
P652UNII21G72T1950
P11143WikiProjectMed IDTolvaptan

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