ERCC excision repair 2, TFIIH core complex helicase subunit

mammalian protein found in humans

Wikidata entity: Q426168



P682 biological process ... Q332154 (ageing) ageing
P682 biological process ... Q189101 (cell population proliferation) cell population proliferation
P682 biological process ... Q210538 (DNA repair) DNA repair
P682 biological process ... Q14599311 (apoptotic process) apoptotic process
P682 biological process ... Q14599315 (response to oxidative stress) response to oxidative stress
P682 biological process ... Q14599571 (skin development) skin development
P682 biological process ... Q2714458 (nucleotide-excision repair) nucleotide-excision repair
P682 biological process ... Q4374357 (post-embryonic development) post-embryonic development
P682 biological process ... Q5113927 (chromosome segregation) chromosome segregation
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q14599693 (bone mineralization) bone mineralization
P682 biological process ... Q14633883 (regulation of transcription, DNA-templated) regulation of transcription, DNA-templated
P682 biological process ... Q14763010 (transcription, DNA-templated) transcription, DNA-templated
P682 biological process ... Q14818001 (in utero embryonic development) in utero embryonic development
P682 biological process ... Q14818018 (cellular response to DNA damage stimulus) cellular response to DNA damage stimulus
P682 biological process ... Q14818059 (multicellular organism growth) multicellular organism growth
P682 biological process ... Q14818066 (positive regulation of transcription, DNA-templated) positive regulation of transcription, DNA-templated
P682 biological process ... Q14818068 (positive regulation of transcription by RNA polymerase II) positive regulation of transcription by RNA polymerase II
P682 biological process ... Q14818114 (response to UV) response to UV
P682 biological process ... Q14819239 (response to hypoxia) response to hypoxia
P682 biological process ... Q14819248 (UV protection) UV protection
P682 biological process ... Q14819468 (extracellular matrix organization) extracellular matrix organization
P682 biological process ... Q14852015 (erythrocyte maturation) erythrocyte maturation
P682 biological process ... Q14860195 (embryonic organ development) embryonic organ development
P682 biological process ... Q14860785 (transcription initiation from RNA polymerase II promoter) transcription initiation from RNA polymerase II promoter
P682 biological process ... Q14863696 (positive regulation of DNA binding) positive regulation of DNA binding
P682 biological process ... Q14863990 (hematopoietic stem cell differentiation) hematopoietic stem cell differentiation
P682 biological process ... Q14864650 (transcription by RNA polymerase II) transcription by RNA polymerase II
P682 biological process ... Q21095148 (regulation of mitotic cell cycle phase transition) regulation of mitotic cell cycle phase transition
P682 biological process ... Q21101212 (regulation of mitotic recombination) regulation of mitotic recombination
P682 biological process ... Q21110091 (nucleotide-excision repair, DNA incision, 3'-to lesion) nucleotide-excision repair, DNA incision, 3'-to lesion
P682 biological process ... Q21110092 (nucleotide-excision repair, DNA incision, 5'-to lesion) nucleotide-excision repair, DNA incision, 5'-to lesion
P682 biological process ... Q21122185 (nucleotide-excision repair, preincision complex assembly) nucleotide-excision repair, preincision complex assembly
P682 biological process ... Q21973809 (global genome nucleotide-excision repair) global genome nucleotide-excision repair
P682 biological process ... Q22244505 (positive regulation of mitotic recombination) positive regulation of mitotic recombination
P682 biological process ... Q22305161 (nucleotide-excision repair, preincision complex stabilization) nucleotide-excision repair, preincision complex stabilization
P682 biological process ... Q14865169 (viral process) viral process
P682 biological process ... Q14878260 (transcription elongation from RNA polymerase II promoter) transcription elongation from RNA polymerase II promoter
P682 biological process ... Q14880758 (nucleobase-containing compound metabolic process) nucleobase-containing compound metabolic process
P682 biological process ... Q14883731 (DNA duplex unwinding) DNA duplex unwinding
P682 biological process ... Q14902239 (transcription-coupled nucleotide-excision repair) transcription-coupled nucleotide-excision repair
P682 biological process ... Q14902768 (hair cell differentiation) hair cell differentiation
P682 biological process ... Q14902813 (hair cycle process) hair cycle process
P682 biological process ... Q14902997 (spinal cord development) spinal cord development
P682 biological process ... Q14907439 (central nervous system myelin formation) central nervous system myelin formation
P682 biological process ... Q14908088 (transcription initiation from RNA polymerase I promoter) transcription initiation from RNA polymerase I promoter
P682 biological process ... Q14908089 (transcription elongation from RNA polymerase I promoter) transcription elongation from RNA polymerase I promoter
P682 biological process ... Q14908090 (termination of RNA polymerase I transcription) termination of RNA polymerase I transcription
P682 biological process ... Q14908091 (7-methylguanosine mRNA capping) 7-methylguanosine mRNA capping
P682 biological process ... Q14908092 (nucleotide-excision repair, DNA incision) nucleotide-excision repair, DNA incision
P682 biological process ... Q14908093 (embryonic cleavage) embryonic cleavage
P682 biological process ... Q14908094 (hair follicle maturation) hair follicle maturation
P682 biological process ... Q14916133 (nucleotide-excision repair, DNA duplex unwinding) nucleotide-excision repair, DNA duplex unwinding
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q154626 (cytoskeleton) cytoskeleton
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q918594 (spindle) spindle
P681 cell component ... Q14817956 (nucleoplasm) nucleoplasm
P681 cell component ... Q14817959 (transcription factor TFIID complex) transcription factor TFIID complex
P681 cell component ... Q21095146 (transcription factor TFIIH core complex) transcription factor TFIIH core complex
P681 cell component ... Q22328441 (CAK-ERCC2 complex) CAK-ERCC2 complex
P681 cell component ... Q14864975 (cyclin-dependent protein kinase activating kinase holoenzyme complex) cyclin-dependent protein kinase activating kinase holoenzyme complex
P681 cell component ... Q14908082 (transcription factor TFIIH holo complex) transcription factor TFIIH holo complex
P681 cell component ... Q14908083 (MMXD complex) MMXD complex
P702 encoded by ... Q14908096 (ERCC2) ERCC2
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P692 Gene Atlas image CommonsMedia http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20ERCC2%20213468%20at%20fs.png ???
P527 has part(s) ... Q24770062 (Helical and beta-bridge domain) Helical and beta-bridge domain
P527 has part(s) ... Q24770507 (DEAD2) DEAD2
P527 has part(s) ... Q24775413 (ATP-dependent helicase, C-terminal) ATP-dependent helicase, C-terminal
P527 has part(s) ... Q24775566 (DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
P527 has part(s) ... Q24779769 (Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type) Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
P527 has part(s) ... Q24780445 (Helicase-like, DEXD box c2 type) Helicase-like, DEXD box c2 type
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q13667380 (metal ion binding) metal ion binding
P680 molecular function ... Q14353168 (hydrolase activity) hydrolase activity
P680 molecular function ... Q14633858 (DNA binding) DNA binding
P680 molecular function ... Q14817978 (damaged DNA binding) damaged DNA binding
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14817992 (protein N-terminus binding) protein N-terminus binding
P680 molecular function ... Q14818106 (protein C-terminus binding) protein C-terminus binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14864825 (nucleic acid binding) nucleic acid binding
P680 molecular function ... Q14875005 (DNA helicase activity) DNA helicase activity
P680 molecular function ... Q14875014 (helicase activity) helicase activity
P680 molecular function ... Q14883421 (4 iron, 4 sulfur cluster binding) 4 iron, 4 sulfur cluster binding
P680 molecular function ... Q14883461 (iron-sulfur cluster binding) iron-sulfur cluster binding
P680 molecular function ... Q14906108 (protein-macromolecule adaptor activity) protein-macromolecule adaptor activity
P680 molecular function ... Q14907734 (ATP-dependent activity, acting on DNA) ATP-dependent activity, acting on DNA
P680 molecular function ... Q14908084 (RNA polymerase II CTD heptapeptide repeat kinase activity) RNA polymerase II CTD heptapeptide repeat kinase activity
P680 molecular function ... Q14908085 (5'-3' DNA helicase activity) 5'-3' DNA helicase activity
P680 molecular function ... Q14908099 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
P361 part of ... Q24726930 (P-loop containing nucleoside triphosphate hydrolase) P-loop containing nucleoside triphosphate hydrolase
P361 part of ... Q24771117 (RAD3/XPD family) RAD3/XPD family
P361 part of ... Q83139843 (Helical and beta-bridge domain, protein family) Helical and beta-bridge domain, protein family
P361 part of ... Q83139877 (DEAD2, protein family) DEAD2, protein family
P361 part of ... Q83145484 (ATP-dependent helicase, C-terminal domain, protein family) ATP-dependent helicase, C-terminal domain, protein family
P361 part of ... Q83146961 (Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type, protein family) Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type, protein family
P361 part of ... Q83164668 (Helicase-like, DEXD box c2 type, protein family) Helicase-like, DEXD box c2 type, protein family
P361 part of ... Q95351462 (DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site, protein family) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site, protein family

External Ids
P705Ensembl protein IDENSP00000375805
P705Ensembl protein IDENSP00000465593
P705Ensembl protein IDENSP00000375809
P705Ensembl protein IDENSP00000466998
P705Ensembl protein IDENSP00000375808
P705Ensembl protein IDENSP00000464887
P705Ensembl protein IDENSP00000431229
P705Ensembl protein IDENSP00000465207
P646Freebase ID/m/02pjd1t
P486MeSH descriptor IDD051759
P672MeSH tree codeD08.811.277.040.025.159.500
P672MeSH tree codeD08.811.399.340.500
P672MeSH tree codeD12.776.260.775.875.875.500
P672MeSH tree codeD12.776.930.930.875.875.500
P6366Microsoft Academic ID (discontinued)2778883343
P10283OpenAlex IDC2778883343
P638PDB structure ID5IY6
P638PDB structure ID5IY7
P638PDB structure ID5IY8
P638PDB structure ID5IY9
P638PDB structure ID5IVW
P637RefSeq protein IDNP_000391
P637RefSeq protein IDNP_001124339
P637RefSeq protein IDXP_011524913
P637RefSeq protein IDXP_016881956
P2892UMLS CUIC0168553
P352UniProt protein IDP18074

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