Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum

scientific article published on 14 May 2007

Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.01330-06
P932PMC publication ID1913261
P698PubMed publication ID17502414

P50authorAlbin FontaineQ57298104
Bruno PradinesQ60044507
Christophe RogierQ60048789
Sébastien BriolantQ60244022
Thierry FusaiQ114440111
Joel MosnierQ114721458
Eric BaretQ114721466
Marylin Torrentino-MadametQ114721472
P2093author name stringMaud Henry
P2860cites workSalmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferationQ35550354
Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studiesQ35810617
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors lovastatin and simvastatin inhibit in vitro development of Plasmodium falciparum and Babesia divergens in human erythrocytesQ35820841
Role of P-glycoprotein in statin drug interactionsQ36634221
Toxicity of statins on rat skeletal muscle mitochondriaQ40225246
Activity, pharmacological inhibition and biological regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Trypanosoma brucei.Q41934019
Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene unitsQ42079385
Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.Q42091736
The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growthQ42826831
Plasmodium falciparum: the lethal effects of tunicamycin and mevastatin on the parasite are not mediated by the inhibition of N-linked oligosaccharide biosynthesisQ43683370
Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparumQ44088868
Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicansQ44678465
Validated HPLC-MS-MS method for simultaneous determination of atorvastatin and 2-hydroxyatorvastatin in human plasma-pharmacokinetic studyQ80149477
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectPlasmodium falciparumQ311383
P304page(s)2654-2655
P577publication date2007-05-14
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleAtorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum
P478volume51

Reverse relations

cites work (P2860)
Q38938937Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii.
Q38852074Antileishmanial effect of mevastatin is due to interference with sterol metabolism.
Q35660950Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii.
Q40936537Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum
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Q41938814Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria
Q34669052Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage
Q35753471Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model
Q53684271Atorvastatin: In-Vivo Synergy with Metronidazole as Anti-Blastocystis Therapy.
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Q33712676In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum
Q93030858Primaquine derivatives: Modifications of the terminal amino group
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Q43111774Simvastatin treatment shows no effect on the incidence of cerebral malaria or parasitemia during experimental malaria
Q43185216Statins alone are ineffective in cerebral malaria but potentiate artesunate
Q37190868Statins as potential antimalarial drugs: low relative potency and lack of synergy with conventional antimalarial drugs
Q46322657Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets

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