Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats

scientific article published on 21 February 2011

Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1155/2011/670613
P932PMC publication ID3043292
P698PubMed publication ID21403895
P5875ResearchGate publication ID50396038

P2093author name stringHao Liu
Ying Jiang
Yong Hu
Qing Di
Nian Yu
Yan-fang Zhang
Ying-dong Zhang
Yu-kui Yan
P2860cites workCOX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic ratsQ43270169
Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibitionQ44308080
Protection against kainate neurotoxicity by pyrrolidine dithiocarbamateQ44932040
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variablesQ46417699
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signalingQ46840766
Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic ratsQ48225832
Kainic acid-induced activation of nuclear factor-kappaB in rat hippocampusQ48293918
Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrierQ48355279
Inhibition of P-glycoprotein over-expression by shRNA-mdr1b in rat astrocytesQ49014147
Nuclear factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampusQ73307512
[Mechanisms of drug resistance in epilepsy]Q79911136
Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulationQ80863693
A critical overview of the influence of inflammation and infection on P-glycoprotein expression and activity in the brainQ81980012
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Early identification of refractory epilepsyQ28144133
Modification of seizure activity by electrical stimulation. II. Motor seizureQ28236678
Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrierQ28385084
Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrierQ28572624
Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endotheliaQ28578682
Regulation and function of NF-kappaB transcription factors in the immune systemQ29616427
Biochemistry of multidrug resistance mediated by the multidrug transporterQ29616476
Cellular injury and neuroinflammation in children with chronic intractable epilepsyQ33611760
Blood-brain barrier active efflux transporters: ATP-binding cassette gene familyQ33985133
Drug resistance in brain diseases and the role of drug efflux transporters.Q33988704
NF-kappaB in neuronal plasticity and neurodegenerative disordersQ34131754
Evidence that reactive oxygen species do not mediate NF-kappaB activationQ35160731
Design-based stereology in neuroscienceQ36010838
Potential role of drug transporters in the pathogenesis of medically intractable epilepsyQ36023613
Brain inflammation in epilepsy: experimental and clinical evidenceQ36319367
Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats.Q36478822
ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsyQ36957955
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal modelsQ37391731
Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulationQ38299579
Several major antiepileptic drugs are substrates for human P-glycoproteinQ39934629
Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus modelQ39945676
PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.Q39959297
Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cellsQ40024086
Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcriptionQ40372631
Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytesQ40786596
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.Q41598067
Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosisQ42526811
Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathwaysQ43201818
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectseizureQ6279182
P304page(s)670613
P577publication date2011-02-21
P1433published inMediators of InflammationQ2144494
P1476titleNuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats
P478volume2011

Reverse relations

cites work (P2860)
Q35132580ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis
Q51074054DPP4 regulates the inflammatory response in a rat model of febrile seizures.
Q39164058Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance
Q35814925HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products
Q34401462Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia
Q35204215Influence of pentylenetetrazol and NF-κB decoy oligodeoxynucleotides on p38 expression in neuron-like cells
Q36634134Modulation of Immunity and the Inflammatory Response: A New Target for Treating Drug-resistant Epilepsy
Q45084169Myoloid-related protein 8, an endogenous ligand of Toll-like receptor 4, is involved in epileptogenesis of mesial temporal lobe epilepsy via activation of the nuclear factor-κB pathway in astrocytes
Q48259331Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid
Q37388599Pyrrolidine dithiocarbamate (PDTC) inhibits the overexpression of MCP-1 and attenuates microglial activation in the hippocampus of a pilocarpine-induced status epilepticus rat model
Q35027962Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.
Q47194378α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation

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