The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review

scientific article published on 23 October 2017

The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814
systematic reviewQ1504425

External links are
P5530Altmetric DOI10.1186/S12885-017-3693-7
P6179Dimensions Publication ID1092310847
P356DOI10.1186/S12885-017-3693-7
P953full work available at URLhttp://eprints.whiterose.ac.uk/128063/
P932PMC publication ID5654013
P698PubMed publication ID29061138
P1154Scopus EID2-s2.0-85031914389

P50authorJacqui A ShawQ61264525
Angela CoxQ28484012
Orla SheilsQ30348428
P2093author name stringIan A Cree
Dawn Teare
Lesley Uttley
Susan Harnan
Michael Messenger
Helen Buckley Woods
Anne Reiman
Sian Taylor Philips
Becky L Whiteman
Hugh Kikuchi
UK Early Cancer Detection Consortium
P2860cites workDetection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosisQ73121380
Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patientsQ79362867
Elevated level of cell-free plasma DNA is associated with breast cancerQ80152253
Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNAQ80166978
Levels of circulating cell-free serum DNA in benign and malignant breast lesionsQ80430527
The detection of oesophageal adenocarcinoma by serum microsatellite analysisQ83056034
Methylation of multiple genes as a candidate biomarker in non-small cell lung cancerQ83264629
CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancerQ83843096
Quantitative measurement of cell-free plasma DNA and applications for detecting tumor genetic variation and promoter methylation in a clinical settingQ84115839
Noninvasive prenatal diagnosis: from dream to realityQ85663657
Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancerQ87567670
Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma.Q50888098
Circadian Rhythm of Methylated Septin 9, Cell-Free DNA Amount and Tumor Markers in Colorectal Cancer Patients.Q50981768
Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum.Q51140319
Methylation of the DCLK1 promoter region in circulating free DNA and its prognostic value in lung cancer patients.Q51600504
Molecular Diagnostic of Prostate Cancer From Body Fluids Using Methylation-Specific PCR (MS-PCR) Method.Q51610064
Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002.Q51711228
Validation of a real-time PCR-based qualitative assay for the detection of methylated SEPT9 DNA in human plasma.Q52876183
Microsatellite analysis of induced sputum DNA in patients with lung cancer in heavy smokers and in healthy subjects.Q53026019
STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies.Q53089122
Prostate cancer molecular detection in plasma samples by glutathione S-transferase P1 (GSTP1) methylation analysis.Q53237349
Performance of a second-generation methylated SEPT9 test in detecting colorectal neoplasm.Q53369810
Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma.Q53527046
Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer.Q53588084
Improved sensitivity of circulating tumor DNA measurement using short PCR amplicons.Q54182906
Circulating free DNA in a screening program for early colorectal cancer detection.Q54207521
Quantification of plasma hTERT DNA in hepatocellular carcinoma patients by quantitative fluorescent polymerase chain reaction.Q54356121
Circulating cell-free DNA: a promising marker of regional lymphonode metastasis in breast cancer patients.Q54394872
Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients.Q54428093
Serum cell-free DNA in renal cell carcinoma: a diagnostic and prognostic marker.Q54578238
Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers.Q54714698
Maternal Plasma DNA Sequencing Reveals the Genome-Wide Genetic and Mutational Profile of the FetusQ56937251
Presence of fetal DNA in maternal plasma and serumQ57075132
Tumor Cell-SpecificBRCA1andRASSF1AHypermethylation in Serum, Plasma, and Peritoneal Fluid from Ovarian Cancer PatientsQ57240001
Evaluation of cell-free DNA as a biomarker for pancreatic malignanciesQ57272448
SHOX2 DNA Methylation Is a Biomarker for the Diagnosis of Lung Cancer in PlasmaQ58068480
Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assayQ21090079
Hallmarks of Cancer: The Next GenerationQ22252312
Cell-free DNA as a diagnostic marker for cancer: current insightsQ28074556
Methylation of cell-free circulating DNA in the diagnosis of cancerQ28085699
Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancerQ28243334
Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung CancerQ28390093
Detection of circulating tumor DNA in early- and late-stage human malignanciesQ29615778
Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancerQ33520078
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage.Q33590850
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.Q33663019
Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancerQ33808960
Detection of erbB2 copy number variations in plasma of patients with esophageal carcinomaQ33868284
Improved blood tests for cancer screening: general or specific?Q34086617
Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancerQ34100603
Detection and quantification of mutations in the plasma of patients with colorectal tumorsQ34132363
Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer.Q34322575
Circulating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancerQ34354622
Liquid biopsy: monitoring cancer-genetics in the bloodQ34356149
Novel methylation biomarker panel for the early detection of pancreatic cancerQ34374959
Distinctive DNA methylation patterns of cell-free plasma DNA in women with malignant ovarian tumorsQ34416049
Guidance for laboratories performing molecular pathology for cancer patientsQ34431280
Circulating tumor DNA as a liquid biopsy for cancerQ34447436
Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancerQ34500078
A novel Alu-based real-time PCR method for the quantitative detection of plasma circulating cell-free DNA: sensitivity and specificity for the diagnosis of myocardial infarctionQ34599093
Detection of methylated septin 9 in tissue and plasma of colorectal patients with neoplasia and the relationship to the amount of circulating cell-free DNA.Q34744294
Diagnostic Accuracy of Noninvasive Genotyping of EGFR in Lung Cancer Patients by Deep Sequencing of Plasma Cell-Free DNA.Q50533631
Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy.Q50640273
Plasma nucleic acids in the diagnosis and management of malignant disease.Q34762682
Detection of HER2 amplification in circulating free DNA in patients with breast cancer.Q34806810
Influence of plasma processing on recovery and analysis of circulating nucleic acidsQ35035846
An epigenetic marker panel for detection of lung cancer using cell-free serum DNA.Q35091230
Circulating tumour markers can define patients with normal colons, benign polyps, and cancersQ35125657
Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA.Q35127938
Stage at diagnosis and early mortality from cancer in England.Q35275282
Circulating free DNA as biomarker and source for mutation detection in metastatic colorectal cancerQ35392062
Detection of plasma BRAF(V600E) mutation is associated with lung metastasis in papillary thyroid carcinomasQ35421479
Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing.Q35723986
DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polypsQ35785652
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysisQ35861862
Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinomaQ35940554
Cell-free DNA in blood is a potential diagnostic biomarker of breast cancerQ35995351
Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genesQ36050701
Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping ReviewQ36079639
Quantitative analysis of cell-free DNA in ovarian cancerQ36334715
Tumor-Related Methylated Cell-Free DNA and Circulating Tumor Cells in Melanoma.Q36443927
Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylationQ36614162
Circulating (cell-free) nucleic acids--a promising, non-invasive tool for early detection of several human diseasesQ36731622
Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanomaQ36804878
Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screeningQ36903459
Differential methylation profile of ovarian cancer in tissues and plasmaQ37024691
Detection of aberrant methylation of a six-gene panel in serum DNA for diagnosis of breast cancerQ37109790
Concentration and Methylation of Cell-Free DNA from Blood Plasma as Diagnostic Markers of Renal Cancer.Q37306747
Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancerQ37552649
Validation of the SHOX2/PTGER4 DNA Methylation Marker Panel for Plasma-Based Discrimination between Patients with Malignant and Nonmalignant Lung DiseaseQ37580040
Septin 9 promoter region methylation in free circulating DNA-potential role in noninvasive diagnosis of lung cancer: preliminary reportQ37677042
From discovery to the clinic: the novel DNA methylation biomarker (m)SEPT9 for the detection of colorectal cancer in bloodQ37961764
Tumor markers in clinical practice: a review focusing on common solid cancersQ38010046
Mutation-based detection and monitoring of cell-free tumor DNA in peripheral blood of cancer patientsQ38023058
Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancerQ38327308
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trialQ38385410
Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing systemQ38392527
Detection of PIK3CA mutations in circulating free DNA in patients with breast cancerQ38418038
Assessment of DNA Integrity, Applications for Cancer Research.Q38558563
Rapid Identification of Plasma DNA Samples with Increased ctDNA Levels by a Modified FAST-SeqS Approach.Q38884073
Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosisQ38993983
A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA.Q39159559
Is serum level of methylated RASSF1A valuable in diagnosing hepatocellular carcinoma in patients with chronic viral hepatitis C?Q39258541
Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancerQ39305196
Plasma cell-free DNA levels and integrity in patients with chest radiological findings: NSCLC versus benign lung nodulesQ40015475
Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disordersQ40229747
Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumorsQ40315162
A Comparison of Cell-Free DNA Isolation Kits: Isolation and Quantification of Cell-Free DNA in Plasma.Q40421982
Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients.Q40826236
Circulating tumor DNA outperforms circulating tumor cells for KRAS mutation detection in thoracic malignanciesQ41484128
Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR MethodologyQ41821680
Epigenetic alteration: new insights moving from tissue to plasma - the example of PCDH10 promoter methylation in colorectal cancer.Q42546251
Cell-free DNA concentration and integrity as a screening tool for cancerQ43502233
Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancerQ43526081
CST6 promoter methylation in circulating cell-free DNA of breast cancer patientsQ43599098
Serum DNA hypermethylation in patients with kidney cancer: results of a prospective studyQ43807211
PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis.Q43866102
Use of a new generation of capillary electrophoresis to quantify circulating free DNA in non-small cell lung cancerQ44116681
Detecting lung cancer in plasma with the use of multiple genetic markersQ44656374
Investigation of tumor-derived extracellular DNA in blood of cancer patients by methylation-specific PCR.Q45160146
Colorectal cancer screening with blood-based biomarkers: cost-effectiveness of methylated septin 9 DNA versus current strategiesQ45785843
SOX17 promoter methylation in circulating tumor cells and matched cell-free DNA isolated from plasma of patients with breast cancerQ46393758
Parallel assessment of circulatory cell-free DNA by PCR and nucleosomes by ELISA in breast tumorsQ46482013
Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer.Q46622188
Circulating cell-free DNA, SLC5A8 and SLC26A4 hypermethylation, BRAF(V600E): A non-invasive tool panel for early detection of thyroid cancerQ47817610
Clinical relevance of alterations in quantity and quality of plasma DNA in colorectal cancer patients: based on the mutation spectra detected in primary tumorsQ48292008
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectneoplasmQ1216998
cell-free tumour DNAQ19596321
tumor biomarkerQ66205818
early detection of cancerQ66770492
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)697
P577publication date2017-10-23
P1433published inBMC CancerQ326300
P1476titleThe evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review
P478volume17

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cites work (P2860)
Q92655999A Machine Learning Method for Identifying Lung Cancer Based on Routine Blood Indices: Qualitative Feasibility Study
Q55517990A panel of DNA methylation markers for the detection of prostate cancer from FV and DRE urine DNA.
Q55692870Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations.
Q91809276Cell-free DNA analysis in healthy individuals by next-generation sequencing: a proof of concept and technical validation study
Q91742610Circulating tumor DNA in colorectal cancer: opportunities and challenges
Q90091304Comparison of Target Enrichment Platforms for Circulating Tumor DNA Detection
Q48216212Detection and localization of surgically resectable cancers with a multi-analyte blood test.
Q64121613Developing a blood-based gene mutation assay as a novel biomarker for oesophageal adenocarcinoma
Q94586263Hydroxymethylation and tumors: can 5-hydroxymethylation be used as a marker for tumor diagnosis and treatment?
Q94948707Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA
Q93044719Liquid Biopsy in Colorectal Cancer-Current Status and Potential Clinical Applications
Q90322849Liquid biopsy in oncology: a consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology
Q92586446Multiplex methylated DNA testing in plasma with high sensitivity and specificity for colorectal cancer screening
Q64263563Oncosuppressor-Mutated Cells as a Liquid Biopsy Test for Cancer-Screening
Q47348974Panomics for Precision Medicine
Q98288342Potential of modern circulating cell-free DNA diagnostic tools for detection of specific tumour cells in clinical practice
Q92860780Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients
Q90724422Serial mutational tracking in surgically resected locally advanced colorectal cancer with neoadjuvant chemotherapy
Q98578577The International Collaboration for Cancer Classification and Research (IC3 R)
Q90464695Tracking cancer progression: from circulating tumor cells to metastasis
Q90079694Ultrasensitive DNA hypermethylation detection using plasma for early detection of NSCLC: a study in Chinese patients with very small nodules
Q97424206ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper

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