Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia

scientific article

Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia is …
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scholarly articleQ13442814

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P356DOI10.1002/PHAR.1351
P698PubMed publication ID24734312

P50authorSony TutejaQ42654824
P2093author name stringLeAnne T Bloedon
Marina Cuchel
Danielle Duffy
Rajesh Movva
Richard L Dunbar
Ram Gadi
P2860cites workExecutive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)Q27860959
Microsomal triglyceride transfer proteinQ27863447
Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjectsQ28207946
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemiaQ28282776
Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelinesQ29619614
Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitorsQ34556386
Drug interactions with lipid-lowering drugs: mechanisms and clinical relevanceQ34592657
Clinical Pharmacokinetics of AtorvastatinQ35553211
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 studyQ36104706
MTP inhibition as a treatment for dyslipidaemias: time to deliver or empty promises?Q36709542
The effect of gemfibrozil on the pharmacokinetics of rosuvastatinQ40561482
Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitorsQ42168863
Development of a Population Pharmacokinetic Model for Atorvastatin Acid and Its Lactone MetaboliteQ42917105
Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteersQ44704645
ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.Q45993642
ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin.Q46111557
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemiaQ46573174
Comparison of midazolam and simvastatin as cytochrome P450 3A probes.Q48710487
Evaluation of the potential for pharmacokinetic interaction between fenofibrate and ezetimibe: A phase I, open-label, multiple-dose, three-period crossover study in healthy subjects.Q53595852
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttriglycerideQ186319
pharmacokineticsQ323936
hypercholesterolemiaQ762713
P304page(s)227-239
P577publication date2014-03-01
P1433published inPharmacotherapyQ7180800
P1476titlePharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia
P478volume34

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cites work (P2860)
Q89586580Abrogation of postprandial triglyceridemia with dual PPAR α/γ agonist in type 2 diabetes mellitus: a randomized, placebo-controlled study
Q92219039Current Treatment of Familial Hypercholesterolaemia
Q91944007Experimental Therapeutics for Challenging Clinical Care of a Patient with an Extremely Rare Homozygous APOC2 Mutation
Q93049588Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia
Q50952184Lomitapide for the treatment of hypercholesterolemia.
Q38760884Lomitapide for use in patients with homozygous familial hypercholesterolemia: a narrative review
Q91907110Lomitapide: a review of its clinical use, efficacy, and tolerability
Q36040683Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia
Q38528246Management of patients with familial hypercholesterolaemia
Q38225581Microsomal transfer protein (MTP) inhibition-a novel approach to the treatment of homozygous hypercholesterolemia.
Q38839105Progress in the care of common inherited atherogenic disorders of apolipoprotein B metabolism.
Q48526234Treatment Strategy for Dyslipidemia in Cardiovascular Disease Prevention: Focus on Old and New Drugs.
Q26741705Unmet Needs in LDL-C Lowering: When Statins Won't Do!

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