Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse

scientific article published on January 2002

Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HIPO.10005
10.1002/HIPO.10005.ABS
P698PubMed publication ID11918286

P50authorWim CrusioQ120981
Sanne de WitQ87605920
Frans SluyterQ108055796
P2093author name stringBen A Oostra
Yann S Mineur
Ben A. Oostra
Yann S. Mineur
P2860cites workDifferential expression of FMR1, FXR1 and FXR2 proteins in human brain and testisQ24323108
Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficitsQ24657867
Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activationQ24657890
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding proteinQ28117885
Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradoxQ28235115
Characterization and localization of the FMR-1 gene product associated with fragile X syndromeQ28270283
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromeQ28273791
An improved Timm sulphide silver method for light and electron microscopic localization of heavy metals in biological tissuesQ28296613
Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomesQ28303541
Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strainQ31925840
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral testsQ33711537
Complications associated with genetic background effects in research using knockout miceQ33791038
Fragile X syndrome at the turn of the century.Q33899309
Dendritic spine structural anomalies in fragile-X mental retardation syndromeQ33919487
Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memoryQ34035145
Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysisQ34048415
Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distributionQ34049854
Principles for the buffering of genetic variationQ34171380
Neuroanatomy of fragile X syndrome: the temporal lobeQ36734713
Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumesQ37369973
Comparison between the behavioural effects of septal and hippocampal lesions: a reviewQ40154213
Correlations between radial-maze learning and structural variations of septum and hippocampus in rodentsQ40524449
Behavioural and neuroanatomical divergence between two sublines of C57BL/6J inbred miceQ41184517
Hippocampal mossy fiber distributions in mice selected for aggressionQ48122688
Hippocampal mossy fiber distribution covaries with open-field habituation in the mouseQ48188686
Further phenotypical characterisation of two substrains of C57BL/6J inbred mice differing by a spontaneous single-gene mutationQ48232710
Synaptic synthesis of the Fragile X protein: possible involvement in synapse maturation and eliminationQ48233677
Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brainQ48275073
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome.Q48351859
Hereditary covariations of neuronal circuitry and behavior: correlations between the proportions of hippocampal synaptic fields in the regio inferior and two-way avoidance in mice and rats.Q48810127
Mildly impaired water maze performance in male Fmr1 knockout mice.Q48818692
Genetic selection for novelty-induced rearing behavior in mice produces changes in hippocampal mossy fiber distributions.Q48931577
Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function.Q51083891
Ethopharmacological analysis of the effects of putative 'anxiogenic' agents in the mouse elevated plus-maze.Q51119657
KH domains within the FMR1 sequence suggest that fragile X syndrome stems from a defect in RNA metabolism.Q52034009
Covariations between hippocampal mossy fibres and working and reference memory in spatial and non-spatial radial maze tasks in mice.Q52060884
Of mice and mazes: similarities between mice and rats on dry land but not water mazes.Q52199312
Transgenic mouse model for the fragile X syndrome.Q52200260
Behavioral and psychiatric disorders in adult male carriers of fragile X.Q53728865
Long-term potentiation in the hippocampus of fragile X knockout miceQ57828486
Intermale aggression and dark/light preference in ten inbred mouse strainsQ57897044
Strain-dependent epithelial defects in mice lacking the EGF receptorQ58326927
Prevalence of fragile X syndromeQ71578926
The fragile X syndrome and other fragile site disordersQ74790217
The fragile X syndromeQ74809876
P433issue1
P921main subjectcognitive neuroscienceQ1138951
knockout mouseQ1364740
P304page(s)39-46
P577publication date2002-01-01
P1433published inHippocampusQ5768411
P1476titleBehavioral and neuroanatomical characterization of the Fmr1 knockout mouse
Behavioral and neuroanatomical characterization of theFmr1 knockout mouse
P478volume12

Reverse relations

cites work (P2860)
Q38500580A mouse model of fragile X syndrome exhibits heightened arousal and/or emotion following errors or reversal of contingencies.
Q50307286A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse.
Q34505148A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia.
Q36937876Advances in behavioral genetics: mouse models of autism
Q51022589Age-related changes in climbing behavior and neural circuit physiology in Drosophila.
Q38458914Aggression in non-human vertebrates: Genetic mechanisms and molecular pathways.
Q40376074Altered Connectivity and Synapse Maturation of the Hippocampal Mossy Fiber Pathway in a Mouse Model of the Fragile X Syndrome.
Q50344832Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus.
Q35121791Animal models of mental retardation: from gene to cognitive function.
Q30469044Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders
Q35741152Anxiety in mice: a principal component analysis study
Q34137676Assessment of spatial memory in mice.
Q30442883Auditory processing in fragile x syndrome
Q36990260Behavioral Phenotype of Fmr1 Knock-Out Mice during Active Phase in an Altered Light/Dark Cycle.
Q30403591Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background
Q48640185Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin.
Q44473103Brief report: altered social behavior in isolation-reared Fmr1 knockout mice
Q35035766Changes in sensitivity of reward and motor behavior to dopaminergic, glutamatergic, and cholinergic drugs in a mouse model of fragile X syndrome
Q30458768Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders
Q35962611Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice
Q47795409Decreased home cage movement and oromotor impairments in adult Fmr1-KO mice.
Q47069991Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.
Q42482484Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome.
Q36207550Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice.
Q30493672Disruption of Foxg1 expression by knock-in of cre recombinase: effects on the development of the mouse telencephalon
Q34973856Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome
Q33676486Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome
Q41497643Dopamine Release and Uptake Impairments and Behavioral Alterations Observed in Mice that Model Fragile X Mental Retardation Syndrome
Q35906775Dynamics of subcellular proteomes during brain development
Q38978791Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs
Q60932961Effects of Voluntary Exercise on Cell Proliferation and Neurogenesis in the Dentate Gyrus of Adult FMR1 Knockout Mice
Q26829152Emerging pharmacologic treatment options for fragile X syndrome
Q33914148Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.
Q35018423Epigenetic regulation of neuronal dendrite and dendritic spine development
Q34142731Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome
Q35073511Expansion of the dentate mossy fiber-CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus
Q34276734Extinction of an instrumental response: a cognitive behavioral assay in Fmr1 knockout mice
Q40295553Fmr1 knockout mice are impaired in a leverpress escape/avoidance task
Q42226635Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid
Q26865162Fragile X syndrome and targeted treatment trials
Q54782597Fragile X syndrome: From protein function to therapy.
Q38162720Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development
Q27339352Functional magnetic resonance imaging in awake transgenic fragile X rats: evidence of dysregulation in reward processing in the mesolimbic/habenular neural circuit
Q33543082GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism.
Q35125117Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome
Q46075544Genetic rodent models of brain disorders: Perspectives on experimental approaches and therapeutic strategies
Q21135541Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice
Q37417156Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice
Q35492486Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndrome
Q34280548Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype
Q91850695Home-cage hypoactivity in mouse genetic models of autism spectrum disorder
Q39024323Human pluripotent stem cells in modeling human disorders: the case of fragile X syndrome
Q30557514Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model
Q30428162IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
Q33655637Imbalanced pattern completion vs. separation in cognitive disease: network simulations of synaptic pathologies predict a personalized therapeutics strategy
Q34134816Knockout mice: simple solutions to the problems of genetic background and flanking genes
Q26866506Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.
Q47070046Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.
Q24529151Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice
Q33607288Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.
Q37416780Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome
Q92104948MeCP2 Deficiency Disrupts Kainate-Induced Presynaptic Plasticity in the Mossy Fiber Projections in the Hippocampus
Q30420595Modeling fragile X syndrome in the Fmr1 knockout mouse
Q47358832NS-Pten knockout mice show sex- and age-specific differences in ultrasonic vocalizations
Q47551363Negative Effects of Chronic Rapamycin Treatment on Behavior in a Mouse Model of Fragile X Syndrome.
Q34817846Neuroimaging endophenotypes in animal models of autism spectrum disorders: lost or found in translation?
Q35076945Of mice and the fragile X syndrome.
Q36805389Olfactory discrimination learning in mice lacking the fragile X mental retardation protein
Q35009426Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Q55155951Paradoxical effect of baclofen on social behavior in the fragile X syndrome mouse model.
Q51012749Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice.
Q30851354Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
Q48104405Potential Involvement of Impaired BKCa Channel Function in Sensory Defensiveness and Some Behavioral Disturbances Induced by Unfamiliar Environment in a Mouse Model of Fragile X Syndrome
Q38708008Prefrontal Cortex Dysfunction in Fragile X Mice Depends on the Continued Absence of Fragile X Mental Retardation Protein in the Adult Brain.
Q24810315Prenatal exposure to alcohol does not affect radial maze learning and hippocampal mossy fiber sizes in three inbred strains of mouse
Q45192998Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome.
Q40667152Programming social behavior by the maternal fragile X protein.
Q34431654Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule
Q90600697Reversal learning paradigm reveals deficits in cognitive flexibility in the Fmr1 knockout male mouse
Q42512974Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.
Q36350291Self-directed exploration provides a Ncs1-dependent learning bonus
Q29618044Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Q37138180Social approach in genetically engineered mouse lines relevant to autism
Q30603928Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice
Q51828032Spatiotemporal expression of PSD-95 in Fmr1 knockout mice brain.
Q47711512Spectral and temporal properties of calls reveal deficits in ultrasonic vocalizations of adult Fmr1 knockout mice
Q30401824Stem cells and modeling of autism spectrum disorders
Q34140855Sub-strains of Drosophila Canton-S differ markedly in their locomotor behavior
Q37398536Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses
Q38070017Synaptic retinoic acid signaling and homeostatic synaptic plasticity
Q30461456The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome
Q37359934The fragile X mental retardation protein in circadian rhythmicity and memory consolidation
Q35550078Understanding fragile X syndrome: insights from animal models
Q92662989Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour
Q52592966Utility of the Hebb-Williams Maze Paradigm for Translational Research in Fragile X Syndrome: A Direct Comparison of Mice and Humans.
Q24613049What can we learn about autism from studying fragile X syndrome?

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