The ABCC6 transporter: what lessons can be learnt from other ATP-binding cassette transporters?

scientific article published on 16 October 2013

The ABCC6 transporter: what lessons can be learnt from other ATP-binding cassette transporters? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FGENE.2013.00203
P932PMC publication ID3797522
P698PubMed publication ID24137173
P5875ResearchGate publication ID258056708

P50authorMohammad Jakir HosenQ42844882
P2093author name stringAnne De Paepe
Olivier M Vanakker
P2860cites workHypothesizing that histone deacetylase inhibitors can be used to reverse multiple drug resistanceQ39809494
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Identification of a DNA methylation-dependent activator sequence in the pseudoxanthoma elasticum gene, ABCC6.Q40448073
Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitroQ41213819
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Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs.Q45873421
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Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome.Q49107453
Molecular docking characterizes substrate-binding sites and efflux modulation mechanisms within P-glycoprotein.Q50876954
Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays.Q52729873
Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesis.Q54511642
Protein complexes take the baitQ59073296
Residual chloride secretion in intestinal tissue of deltaF508 homozygous twins and siblings with cystic fibrosis. The European CF Twin and Sibling Study ConsortiumQ73977763
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Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidneyQ79896496
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P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injuryQ81241298
Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance-associated protein 2 using ligand-based drug design techniquesQ81556537
ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humansQ82761397
ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemiaQ83654355
Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticumQ84391839
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CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severityQ21261465
Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticumQ24648254
Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutationsQ24674089
MicroRNAs: small RNAs with a big role in gene regulationQ27860896
Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticumQ28118435
Mutations in ABCC6 cause pseudoxanthoma elasticumQ28145590
Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11Q28204843
ABCC6 localizes to the mitochondria-associated membraneQ28271377
The role of ABC transporters in drug resistance, metabolism and toxicityQ28283237
Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubulesQ28390004
Transport function and hepatocellular localization of mrp6 in rat liverQ28572742
ABCC6 expression is regulated by CCAAT/enhancer-binding protein activating a primate-specific sequence located in the first intron of the geneQ28710487
Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosisQ30452653
Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytesQ30467294
The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytesQ34003799
Modifier genes in mice and humansQ34188131
Gene mutation in microRNA target sites of CFTR gene: a novel pathogenetic mechanism in cystic fibrosis?Q34653919
Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6Q35671719
Chloride conductance and genetic background modulate the cystic fibrosis phenotype of Delta F508 homozygous twins and siblingsQ36042699
On the putative co-transport of drugs by multidrug resistance proteinsQ36357084
Strategies for identifying modifier genes in cystic fibrosisQ36698814
Genetic influences on cystic fibrosis lung disease severityQ36785547
Clinical and molecular characterization of the potential CF disease modifier syntaxin 1A.Q37316972
The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptorQ37431941
ABCC2/Abcc2: a multispecific transporter with dominant excretory functions.Q37677056
Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1).Q37818370
Role of ABC transporters in lipid transport and human diseaseQ38082105
Circulating miRNAs as sensitive and specific biomarkers for the diagnosis and monitoring of human diseases: promises and challengesQ38096703
Regional variations in ABC transporter expression along the mouse intestinal tractQ38346757
Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ΔF508 cystic fibrosis airway epitheliumQ39189253
P304page(s)203
P577publication date2013-10-16
P1433published inFrontiers in GeneticsQ2499875
P1476titleThe ABCC6 transporter: what lessons can be learnt from other ATP-binding cassette transporters?
P478volume4

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cites work (P2860)
Q48133234ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells
Q34013439ABCC6- a new player in cellular cholesterol and lipoprotein metabolism?
Q93369365Dietary Pyrophosphate Modulates Calcification in a Mouse Model of Pseudoxanthoma Elasticum: Implication for Treatment of Patients
Q26798431From variome to phenome: Pathogenesis, diagnosis and management of ectopic mineralization disorders
Q36427010In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

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