Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom

scientific article published on 17 April 2007

Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1063-5823(06)59004-0
P698PubMed publication ID25168134

P50authorPhilip A. GottliebQ38327260
P2093author name stringFrederick Sachs
Thomas M Suchyna
P2860cites workNeuronal plasma membrane dynamics evoked by osmomechanical perturbationsQ77649016
Ion channels as tools to monitor lipid bilayer-membrane protein interactions: gramicidin channels as molecular force transducersQ77898051
High-speed pressure clampQ78419349
Gadolinium reduces short-term stretch-induced muscle damage in isolated mdx mouse muscle fibresQ79171939
Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiologyQ81781549
Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular storesQ83839829
X-ray structure of a voltage-dependent K+ channelQ22337257
Mechanosensitivity of N-type calcium channel currentsQ24537561
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton.Q24539089
Desensitization of mechano-gated K2P channelsQ24546917
Analytic models for mechanotransduction: gating a mechanosensitive channelQ24633961
Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channelsQ24644644
Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubesQ24679517
Solution structure of peptide toxins that block mechanosensitive ion channelsQ27639244
Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gatingQ27643031
Therapeutic potential of venom peptidesQ28207222
Molecular basis of mechanosensory transductionQ28216286
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gatingQ28217366
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tensionQ28217369
A large-conductance mechanosensitive channel in E. coli encoded by mscL aloneQ28285850
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channelQ28291702
Dipole potentials indicate restructuring of the membrane interface induced by gadolinium and beryllium ionsQ28360968
Changes in mechanosensitive channel gating following mechanical stimulation in skeletal muscle myotubes from the mdx mouseQ28504996
TRP channels as cellular sensorsQ29615917
Stretch-activation and stretch-inactivation of Shaker-IR, a voltage-gated K+ channelQ33423236
Usefulness and limitations of linear approximations to the understanding of Ca++ signalsQ33544680
Molecular basis of mechanotransduction in living cells.Q33939989
Lipid and mechano-gated 2P domain K(+) channels.Q34083994
Dynamic signaling between astrocytes and neuronsQ34142203
Mechanosensitive channels in prokaryotes.Q34199291
A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venomQ34331989
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.Q34331994
Touch at the molecular level. MechanosensationQ34396908
Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activitiesQ34419888
Intermediate filaments and the function of the dystrophin-protein complexQ34772631
Pharmacological control of cellular calcium handling in dystrophic skeletal muscleQ34807192
Calcium oscillations encoding neuron-to-astrocyte communicationQ35006283
Sensory transduction in the ear.Q35011465
Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactionsQ35116324
Evolutionary origins of mechanosensitive ion channels.Q35121807
Effects of acute ventricular volume manipulation on in situ cardiomyocyte cell membrane configuration.Q35121867
Pharmacological strategies for muscular dystrophyQ35128906
Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist, Cereport.Q35130192
A common mechanism underlies stretch activation and receptor activation of TRPC6 channelsQ35133928
New TRP channels in hearing and mechanosensation.Q35202290
The structures of BtuCD and MscS and their implications for transporter and channel functionQ35590009
Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP.Q35844666
Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cellsQ36211594
Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscLQ36412105
Membrane tension accelerates rate-limiting voltage-dependent activation and slow inactivation steps in a Shaker channelQ36412511
Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channelsQ36412562
Molecular and cellular mechanism of endothelin regulation. Implications for vascular functionQ36428209
Endothelin-1 regulates cytosolic and nuclear Ca2+ in human endocardial endotheliumQ73190215
Dynamic properties of stretch-activated K+ channels in adult rat atrial myocytesQ73355461
Na(+) entry via store-operated channels modulates Ca(2+) signaling in arterial myocytesQ73376844
Astrocyte-neurone crosstalk: variants of the same language?Q73500929
Tarantula peptide inhibits atrial fibrillationQ73851329
Biological membranes as bilayer couples. III. Compensatory shape changes induced in membranesQ38526301
FMRFamide and membrane stretch as activators of the Aplysia S-channelQ39453017
The breakdown of cell membranes by electrical and mechanical stressQ40124411
Voltage‐dependent ion channels in glial cellsQ40393324
Stretch-activated ion channels in the heartQ41529536
Mechanosensitive ion channels in nonspecialized cellsQ41748707
A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptidesQ42131475
Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure.Q42474869
Dependence of endothelin-1 secretion on Ca2+.Q42479964
Effect of intracellular Ca2+ concentration on endothelin-1 secretionQ42496596
The principle of gating charge movement in a voltage-dependent K+ channelQ42598185
Thrombin-stimulated phosphorylation of myosin light chain and its possible involvement in endothelin-1 secretion from porcine aortic endothelial cellsQ43980342
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation.Q44240672
Paradoxical Ca2+ rises induced by low external Ca2+ in rat hippocampal neurones.Q44401244
cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channelsQ44617727
Genistein Can Modulate Channel Function by a Phosphorylation-Independent Mechanism: Importance of Hydrophobic Mismatch and Bilayer MechanicsQ44657959
Characterization of a functionally expressed stretch-activated BKca channel cloned from chick ventricular myocytesQ44729145
Mediation of cell volume regulation by Ca2+ influx through stretch-activated channelsQ45118086
Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse.Q45140549
Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cellQ46565359
Protein folding in membranes: determining energetics of peptide-bilayer interactionsQ46793719
Effect of mechanogated membrane ion channel blockers on experimental traumatic brain oedemaQ47744719
Thrombin is a regulator of astrocytic endothelin-1.Q48346742
Mechanotransducing ion channels in astrocytesQ48456747
Activation of endothelin receptors by sarafotoxin regulates Ca2+ homeostasis in cerebellar astrocytesQ48600803
Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real timeQ48744551
Are several G proteins involved in the different effects of endothelin-1 in mouse striatal astrocytes?Q48759971
Astrocytes are target cells for endothelins and sarafotoxinQ48960303
TRPC1 forms the stretch-activated cation channel in vertebrate cells.Q50666878
Drosophila mutant with a transducer defectQ50954286
Rescue of the Drosophila phototransduction mutation trp by germline transformation.Q52466492
Responses of neurons to extreme osmomechanical stress.Q52508946
Role of Ca2+ and protein kinase C in shear stress-induced actin depolymerization and endothelin 1 gene expression.Q52512035
Retaining your identity under stress.Q54539288
Free calcium rise and mitogenesis in glial cells caused by endothelin.Q55484913
Mechanosensitive channels: what can we learn from ?simple? model systems?Q56768787
[24] Mechanosensitive channels of bacteriaQ58037440
Cardiac Mechanosensitivity and Stretch-Activated Ion ChannelsQ58822985
Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmiasQ67542094
Amiloride: a molecular probe for mechanosensitive channelsQ67544173
Role of the cytoskeleton in Ca2+ release from the intracellular Ca store of rat peritoneal mast cellsQ67980687
C-terminal amidation of neuropeptides. Gly-Lys-Arg extension an efficient precursor of C-terminal amideQ70466224
Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neuronsQ70901392
Sodium influx via a non-selective pathway activated by the removal of extracellular divalent cations: possible role in the calcium paradoxQ73119941
Stretch-induced endothelin-1 production by astrocytesQ73190104
P921main subjectvenomQ3386847
P304page(s)81-109
P577publication date2007-04-17
P1433published inCurrent Topics in MembranesQ15763301
P1476titleProperties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom
P478volume59

Reverse relations

cites work (P2860)
Q83163285Concentration dependent effect of GsMTx4 on mechanosensitive channels of small conductance in E. coli spheroplasts
Q90608717Inhibition of Piezo1 attenuates demyelination in the central nervous system
Q91962796Rapid flow-induced activation of Gαq/11 is independent of Piezo1 activation
Q34601086Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
Q24601391The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4
Q36615017Twenty odd years of stretch-sensitive channels

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