The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.

scientific article published on 5 June 2006

The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M604550200
P698PubMed publication ID16754662

P50authorDavid CraikQ37375333
David J. AdamsQ37829157
Richard J. ClarkQ37375290
Harald FischerQ5653759
P2093author name stringSimon T Nevin
P2860cites work1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effectsQ29616506
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)23254-23263
P577publication date2006-06-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.
P478volume281

Reverse relations

cites work (P2860)
Q34575566A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily.
Q27681218A novel  4/7-conotoxin LvIA from Conus lividus that selectively blocks  3 2 vs.  6/ 3 2 3 nicotinic acetylcholine receptors
Q30878761A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists
Q27646907AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
Q33621205Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors
Q37336577Alpha9 nicotinic acetylcholine receptors and the treatment of pain
Q44676738Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.
Q36159142Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels
Q64076290Antibodies and venom peptides: new modalities for ion channels
Q33782635Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor
Q38175134Calcium-permeable ion channels in pain signaling
Q34156116Chemical synthesis and characterization of two α4/7-conotoxins
Q39424563Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.
Q35432836Cone snail venomics: from novel biology to novel therapeutics
Q26783037Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
Q33736765Conotoxins targeting nicotinic acetylcholine receptors: an overview
Q30367509Constraining cyclic peptides to mimic protein structure motifs.
Q64074559Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors
Q48198015Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain
Q37677444Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation
Q58097124Discovery Methodology of Novel Conotoxins from Species
Q28481593Discovery of defense- and neuropeptides in social ants by genome-mining
Q33693128Disulfide Bond Assignments by Mass Spectrometry of Native Natural Peptides: Cysteine Pairing in Disulfide Bonded Conotoxins
Q35063148Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?
Q39234026Enhancing the therapeutic potential of peptide toxins
Q37954330From toxins targeting ligand gated ion channels to therapeutic molecules
Q47104016G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides
Q33400496High throughput electrophysiology with Xenopus oocytes
Q37348886Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.
Q35974234Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.
Q35735112Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV current
Q46272595Molecular Engineering of Conus Peptides as Therapeutic Leads
Q24673308Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors
Q64250595Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors
Q37978834NMR as an effective tool for the structure determination of lasso peptides
Q37590093Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Q35853738Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats
Q94568897On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe
Q50111328Potential Uses of Isolated Toxin Peptides in Neuropathic Pain Relief: A Literature Review
Q39897555Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives
Q36507136Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli.
Q28075856Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
Q55712030Role of CysI–CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors.
Q37339057Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor
Q37077635Strategies for the development of conotoxins as new therapeutic leads
Q92989648Structural and Functional Analyses of Cone Snail Toxins
Q34695631Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels
Q37954299Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads
Q30494943The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation
Q46777407The three-dimensional structure of the analgesic alpha-conotoxin, RgIA.
Q33369942Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function
Q34777866Understanding the structure/activity relationships of the iron regulatory peptide hepcidin
Q33809867Use of venom peptides to probe ion channel structure and function
Q39405111α9-containing nicotinic acetylcholine receptors and the modulation of pain.
Q34333395α9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia
Q36078883γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins

Search more.