Safety and Efficacy of Pembrolizumab in Advanced, Programmed Death Ligand 1-Positive Cervical Cancer: Results From the Phase Ib KEYNOTE-028 Trial.

scientific article published on 2 November 2017

Safety and Efficacy of Pembrolizumab in Advanced, Programmed Death Ligand 1-Positive Cervical Cancer: Results From the Phase Ib KEYNOTE-028 Trial. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.2017.74.5471
P698PubMed publication ID29095678

P50authorSarina Piha-PaulQ56890176
Jean-Sébastien FrénelQ58259189
Hope RugoQ55975497
P2093author name stringChristophe Le Tourneau
Reshma Rangwala
Andrea Varga
Carlos Gomez-Roca
Patrick A Ott
Emilie M J van Brummelen
Sanatan Saraf
Shari Thomas
Bert O'Neil
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectcervix uterine cancerQ160105
pembrolizumabQ13896859
P304page(s)4035-4041
P577publication date2017-11-02
P1433published inJournal of Clinical OncologyQ400292
P1476titleSafety and Efficacy of Pembrolizumab in Advanced, Programmed Death Ligand 1-Positive Cervical Cancer: Results From the Phase Ib KEYNOTE-028 Trial
P478volume35

Reverse relations

cites work (P2860)
Q61807226-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure
Q90292730A Case of Nivolumab-Induced Bullous Pemphigoid: Review of Dermatologic Toxicity Associated with Programmed Cell Death Protein-1/Programmed Death Ligand-1 Inhibitors and Recommendations for Diagnosis and Management
Q56515605A Phase I Evaluation of Extended Field Radiation Therapy With Concomitant Cisplatin Chemotherapy Followed by Paclitaxel and Carboplatin Chemotherapy in Women With Cervical Carcinoma Metastatic to the Para-aortic Lymph Nodes: An NRG Oncology/Gynecolog
Q90287047A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers
Q92016091A systematic analysis of immune genes and overall survival in cancer patients
Q100762157Baseline immunity and impact of chemotherapy on immune microenvironment in cervical cancer
Q52570998Bevacizumab with metronomic chemotherapy of low-dose oral cyclophosphamide in recurrent cervical cancer: Four cases.
Q52582301Cervical cancer - State of the science: From angiogenesis blockade to checkpoint inhibition.
Q90953584Cervical cancer patients that respond to chemoradiation therapy display an intense tumor infiltrating immune profile before treatment
Q64914511Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome.
Q90354145Clinical study of nimotuzumab combined with concurrent radiochemotherapy for treatment of locally advanced cervical cancer
Q64983989Clinical utility of pembrolizumab in the management of advanced solid tumors: an evidence-based review on the emerging new data.
Q59808385Combination Immune Checkpoint Blockade Strategies to Maximize Immune Response in Gynecological Cancers
Q91906078Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
Q56890243Current landscape and future directions of biomarkers for predicting responses to immune checkpoint inhibitors
Q93335065Early disease progression and treatment discontinuation in patients with advanced ovarian cancer receiving immune checkpoint blockade
Q92202201Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: Multicenter, open-label phase 2 trial
Q64239710Efficacy of PD-1 blockade in cervical cancer is related to a CD8FoxP3CD25 T-cell subset with operational effector functions despite high immune checkpoint levels
Q98164819Efficacy of PD-1/PD-L1 blockade monotherapy in clinical trials
Q99552004Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors
Q92562854Evidence-Based Treatment Paradigms for Management of Invasive Cervical Carcinoma
Q59329233Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium
Q57072711Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy
Q97645835High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions
Q92285498Immune checkpoint expression, microsatellite instability, and mutational burden: Identifying immune biomarker phenotypes in uterine cancer
Q92638791Immune checkpoint inhibitors in the treatment of virus-associated cancers
Q90164090Immunotherapy for Uterine Cervical Cancer
Q90642659LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype
Q90091962Looking past PD-L1: expression of immune checkpoint TIM-3 and its ligand galectin-9 in cervical and vulvar squamous neoplasia
Q54952356Major clinical research advances in gynecologic cancer in 2017.
Q90702080Moving Forward in Cervical Cancer - Enhancing Susceptibility to DNA Repair Inhibition and Damage: NCI Clinical Trials Planning Meeting Report
Q98158105Neratinib in patients with HER2-mutant, metastatic cervical cancer: Findings from the phase 2 SUMMIT basket trial
Q64104791Next generation sequencing driven successful combined treatment with laparoscopic surgery and immunotherapy for relapsed stage IVB cervical and synchronous stage IV lung cancer
Q92363011Novel Delivery Systems for Checkpoint Inhibitors
Q61803811PD-1/PD-L1 Inhibitors in Cervical Cancer
Q59357945PD-1/PD-L1 immune checkpoint inhibitors in advanced cervical cancer
Q92705771Phase I Study of a B Cell-Based and Monocyte-Based Immunotherapeutic Vaccine, BVAC-C in Human Papillomavirus Type 16- or 18-Positive Recurrent Cervical Cancer
Q92560472Phase II evaluation of nivolumab in the treatment of persistent or recurrent cervical cancer (NCT02257528/NRG-GY002)
Q89450684Preface: More than two decades of modern tumor immunology
Q91284516Preface: More than two decades of modern tumor immunology
Q95591987Preface: More than two decades of modern tumor immunology
Q99714486Real-World Experience with Pembrolizumab Treatment in Patients with Heavily Treated Recurrent Gynecologic Malignancies
Q64108445Results from a single arm, single stage phase II trial of trametinib and GSK2141795 in persistent or recurrent cervical cancer
Q90642504Risk of Gastrointestinal Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitor Plus Chemotherapy: A Systematic Review and Meta-Analysis
Q88654117Safety, anti-tumour activity, and pharmacokinetics of fixed-dose SHR-1210, an anti-PD-1 antibody in advanced solid tumours: a dose-escalation, phase 1 study
Q92708769TIM-3 in endometrial carcinomas: an immunotherapeutic target expressed by mismatch repair-deficient and intact cancers
Q98164379Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
Q58609934The Role of PD-1 Checkpoint Inhibition in Gynecologic Malignancies
Q64256609The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer
Q58608193Time to abandon single-site irradiation for inducing abscopal effects
Q90300273Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis
Q55386599Tumor molecular profiling of responders and non-responders following pembrolizumab monotherapy in chemotherapy resistant advanced cervical cancer.
Q98946863Uncovering PD-L1 and CD8+ TILS Expression and Clinical Implication in Cervical Squamous Cell Carcinoma
Q102053029Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity
Q98503965Vaginal microbiota, genital inflammation, and neoplasia impact immune checkpoint protein profiles in the cervicovaginal microenvironment

Search more.