Role of Toll-like receptors in health and diseases of gastrointestinal tract

scientific article published on April 2006

Role of Toll-like receptors in health and diseases of gastrointestinal tract is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.V12.I14.2149
P932PMC publication ID4087639
P698PubMed publication ID16610014
P5875ResearchGate publication ID298738528

P2093author name stringWangxue Chen
Greg Harris
Rhonda KuoLee
P2860cites workMD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4Q22009943
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaBQ22010046
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2Q22010443
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diseaseQ22251291
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaBQ24290546
A Toll-like receptor recognizes bacterial DNAQ24290668
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systemsQ24292468
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detectionQ24292675
NLRs join TLRs as innate sensors of pathogensQ24305830
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8Q24310398
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signalingQ24316441
A family of human receptors structurally related to Drosophila TollQ24321888
Structure and function of lipopolysaccharide binding proteinQ24324774
Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptorsQ24629037
Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cellsQ24805624
Toll-like receptorsQ27860671
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseQ27860821
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3Q27860854
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene productQ28141458
Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cellsQ28179206
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharideQ28207950
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expressionQ28211358
Negative regulation of toll-like receptor-mediated signaling by TollipQ28212686
Evasion of Toll-like receptor 5 by flagellated bacteriaQ28256503
CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.Q28344579
Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory responseQ28345391
A toll-like receptor that prevents infection by uropathogenic bacteriaQ28504943
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall componentsQ28511151
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptorsQ28512624
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNAQ28513215
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infectionQ28587620
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responsesQ28588300
Flagellin Is the Major Proinflammatory Determinant of Enteropathogenic SalmonellaQ40633168
Subcellular localization of Toll-like receptor 3 in human dendritic cellsQ40636721
Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cellsQ40800255
Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activationQ40813373
Histological responses to Helicobacter pylori infection: gastritis, atrophy and preneoplasiaQ40946347
Entamoeba histolytica stimulates interleukin 8 from human colonic epithelial cells without parasite-enterocyte contactQ41114131
Ultrastructure of experimental intestinal invasive amebiasisQ41273070
Pathogenesis of enteric infection by CampylobacterQ41346039
An environmentally regulated pilus-like appendage involved in Campylobacter pathogenesisQ42637774
Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritisQ43450468
Bile-induced 'pili' in Campylobacter jejuni are bacteria-independent artifacts of the culture mediumQ43548965
Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection.Q43789480
Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosisQ44281901
Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infectionQ44412922
The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasisQ44933430
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signalingQ44958632
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virusQ45173711
The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.Q45232038
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processingQ45251378
Does Toll-like receptor 3 play a biological role in virus infections?Q45647163
Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP.Q46460985
Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine releaseQ46477488
Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8.Q46809881
TLR signaling at the intestinal epithelial interfaceQ46809965
Toll-like receptor-2 is essential in murine defenses against Candida albicans infectionsQ47248415
NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's diseaseQ47299510
Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitisQ47318019
Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell networkQ47644212
Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunityQ47661604
Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei miceQ47871351
Toll-like receptors are temporally involved in host defenseQ47914772
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitisQ47933212
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humansQ48037814
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathwaysQ48219736
Bacterial lipoprotein induces resistance to Gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearanceQ50094133
Elevated flagellin-specific immunoglobulins in Crohn's diseaseQ50096591
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA.Q50101913
Essential role of MD-2 in LPS responsiveness and TLR4 distributionQ50109313
Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitinationQ50119689
Catalytic properties of lipopolysaccharide (LPS) binding protein. Transfer of LPS to soluble CD14.Q50140195
Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis.Q52858571
Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria.Q54482520
Toll-like receptor-4 signaling mediates pulmonary neutrophil sequestration in response to gram-positive bacterial enterotoxin.Q54545431
Aggregative adherence fimbriae contribute to the inflammatory response of epithelial cells infected with enteroaggregative Escherichia coli.Q54638065
Toll-like receptor 2 is expressed on the intestinal M cells in swine.Q54673362
Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells.Q54776568
Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4Q57969568
Synergistic enhancement of Toll-like receptor responses by NOD1 activationQ57998932
Lipophosphopeptidoglycan of Entamoeba histolytica Induces an Antiinflammatory Innate Immune Response and Downregulation of Toll-Like Receptor 2 (TLR-2) Gene Expression in Human MonocytesQ58608765
Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptorsQ64449475
Helicobacter pylori: I. Ultrastructural sequences of adherence, attachment, and penetration into the gastric mucosaQ71770699
In vivo and in vitro experimental intestinal amebiasis in Mongolian gerbils (Meriones unguiculatus)Q73087762
Strategic compartmentalization of Toll-like receptor 4 in the mouse gutQ73229779
Intestinal myofibroblasts in innate immune responses of the intestineQ73524252
Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cellsQ73948765
Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epitheliumQ73986936
Toll-like receptors 2 and 4 are up-regulated during intestinal inflammationQ74262578
Toll-like receptor 4 (TLR4) plays a relatively minor role in murine defense against primary intradermal infection with Francisella tularensis LVSQ81216147
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
Negative regulation of toll-like receptor-mediated immune responsesQ29619019
Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells.Q30305779
Commentary: the role of the IL-18 system and other members of the IL-1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe?Q30434191
Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathwaysQ30436048
Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut.Q31126525
Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxinsQ33716162
Host determinants of Helicobacter pylori infection and its clinical outcomeQ33723758
The epidemiology of enteric caliciviruses from humans: a reassessment using new diagnostics.Q33914442
Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel diseaseQ34005313
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognitionQ34166263
Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.Q34288934
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity islandQ34359740
The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propriaQ34400418
Acid resistance in enteric bacteriaQ34522511
Toll receptors: a central element in innate immune responsesQ34537817
Allelic variation in TLR4 is linked to susceptibility to Salmonella enterica serovar Typhimurium infection in chickensQ34716297
Recognition of microbial infection by Toll-like receptorsQ35192575
Toll-like receptors in health and disease: complex questions remain.Q35193786
Human intestinal epithelial cells produce proinflammatory cytokines in response to infection in a SCID mouse-human intestinal xenograft model of amebiasis.Q35546207
Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitisQ35596664
Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's diseaseQ35597925
Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epitheliumQ35788690
Role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella enterica serovar Typhimurium infectionQ35801874
Campylobacter, from obscurity to celebrityQ35890445
Battling enteroinvasive bacteria: Nod1 comes to the rescueQ35946246
Endotoxin recognition and signal transduction by the TLR4/MD2-complexQ35982266
Pleiotropic function of Toll-like receptorsQ35982288
Innate immune recognition of the extracellular mucosal pathogen, Helicobacter pyloriQ36097453
Neutrophil transepithelial migration: role of toll-like receptors in mucosal inflammationQ36165930
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)Q36367812
Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategiesQ36369124
Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cellsQ36370326
Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonistsQ36399765
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.Q36746122
Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor familyQ37074042
Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infectionQ37521688
Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4.Q37582815
Bacterial flagellin is a dominant antigen in Crohn disease.Q37698878
Shigella flexneri invasion of HeLa cells induces NF-kappa B DNA-binding activity.Q38315401
Bacterial invasion is not required for activation of NF-kappaB in enterocytesQ39509697
Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis.Q39510203
Release of Toll-like receptor-2-activating bacterial lipoproteins in Shigella flexneri culture supernatantsQ39522417
Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2.Q39522825
Characterization of Shigella type 1 fimbriae: expression, FimA sequence, and phase variation.Q39830217
Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response toSalmonella entericaSerovar Typhimurium andStaphylococcus aureusin MiceQ39912958
Adherence of Helicobacter pylori to primary human gastrointestinal cells.Q40268855
TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1.Q40396415
Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium.Q40402030
The innate immune response to Entamoeba histolytica lipopeptidophosphoglycan is mediated by toll-like receptors 2 and 4.Q40418682
The Vi capsular antigen of Salmonella enterica serotype Typhi reduces Toll-like receptor-dependent interleukin-8 expression in the intestinal mucosa.Q40419113
Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicansQ40431155
Signal transduction in Campylobacter jejuni-induced cytokine productionQ40433354
Helicobacter pylori heat-shock protein 60 induces inflammatory responses through the Toll-like receptor-triggered pathway in cultured human gastric epithelial cellsQ40483845
Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathwayQ40499553
In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strainQ40526966
Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activationQ40532416
Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptorsQ40545709
Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cellsQ40571187
Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5.Q40608367
Intracellular Recognition of Lipopolysaccharide by Toll-like Receptor 4 in Intestinal Epithelial CellsQ40624580
Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modificationsQ40626961
P433issue14
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)2149-2160
P577publication date2006-04-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleRole of Toll-like receptors in health and diseases of gastrointestinal tract
P478volume12

Reverse relations

cites work (P2860)
Q33954369A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins
Q83737484Ability of a commercial feed additive to modulate expression of innate immunity in sheep immunosuppressed with dexamethasone
Q41999007Activation of innate immunity by bacterial ligands of toll-like receptors
Q40801242Altered Th17 Cytokine Expression in Helicobacter pylori Patients with TLR4 (D299G) Polymorphism
Q42471833Attenuation of toll-like receptor 2-mediated innate immune response in patients with alcoholic chronic liver disease
Q37532686Control of mucosal polymicrobial populations by innate immunity
Q34348030Differential gene expression profiling of porcine epithelial cells infected with three enterotoxigenic Escherichia coli strains
Q38562428Diverse functions of defensins and other antimicrobial peptides in periodontal tissues
Q64985624Effect of supplemental yeast cell walls on growth performance, gut mucosal glutathione pathway, proteolytic enzymes and transporters in growing broiler chickens.
Q54448660Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease.
Q34719048Expression of Toll-like receptors 2 and 9 in cells of dog jejunum and colon naturally infected with Leishmania infantum.
Q40274661Female genital tract immunization: evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation
Q47413235Functional activation of macrophages, monocytes and splenic lymphocytes by polysaccharide fraction from Tricholoma matsutake
Q33544931GanedenBC30 cell wall and metabolites: anti-inflammatory and immune modulating effects in vitro
Q36719185Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.
Q36988418Haematopoietic stem cell transplantation: can our genes predict clinical outcome?
Q37310621Immunomodulatory and anti-inflammatory effects of chondroitin sulphate
Q46935942Influence of the gut microbiota on blood acute-phase proteins
Q46040098Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning.
Q34031547Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism
Q34249561Multivariate inference of pathway activity in host immunity and response to therapeutics
Q33907548NOD-like receptors in intestinal homeostasis and epithelial tissue repair
Q37014317Nod-like receptors in innate immunity and inflammatory diseases
Q42092171Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease.
Q36327203Probiotic bacteria prevent Salmonella - induced suppression of lymphoproliferation in mice by an immunomodulatory mechanism
Q58603309Role of gut microbiota in intestinal wound healing and barrier function
Q35668237The Interaction among Microbiota, Immunity, and Genetic and Dietary Factors Is the Condicio Sine Qua Non Celiac Disease Can Develop.
Q38594314The blood-epididymis barrier and inflammation
Q38973178Toll-like receptors -4 and -5 in oral and cutaneous squamous cell carcinomas
Q37389400Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia
Q37265030Toll-like receptors in skin infections and inflammatory diseases.
Q36229423Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus
Q47963460Use of gene profiling to evaluate the effects of a feed additive on immune function in periparturient dairy cattle
Q42732189Wound healing of intestinal epithelial cells

Search more.