Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats.

scientific article published on 6 April 2011

Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/TOXSCI/KFR063
P698PubMed publication ID21427060

P50authorMarija M. JanjicQ46614578
Aleksandar I MihajlovićQ56947987
Silvana A AndricQ57079658
Tatjana KosticQ77124872
P2093author name stringNatasa J Stojkov
Maja M Bjelic
P2860cites workPharmacology of anabolic steroidsQ24650695
Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexesQ28204031
Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thoughtQ28245222
Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3BQ28247233
The luteinizing hormone receptorQ28268737
Androgen abuse in athletes: detection and consequencesQ28272653
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesQ28296995
Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene familyQ28301131
ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cellsQ28513194
Gene expression profiling of androgen receptor antagonists in the rat fetal testis reveals few common gene targetsQ28577862
Hormonal regulation of testicular steroid and cholesterol homeostasisQ30440164
Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexesQ33412546
Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and actionQ33814546
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.Q34062583
Adverse health effects of anabolic-androgenic steroidsQ34098584
Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment.Q34357156
The adaptive response of adult rat Leydig cells to repeated immobilization stress: the role of protein kinase A and steroidogenic acute regulatory protein.Q34657176
Behavioral and physiological responses to anabolic-androgenic steroidsQ35541519
Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and agingQ36130944
Regulation of P450c17 expression in the early embryo depends on GATA factorsQ37106656
Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout miceQ37143613
Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptorQ37326925
Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptorsQ39897838
Androgens in men--uses and abusesQ40965438
Testosterone-induced modulation of nitric oxide-cGMP signaling pathway and androgenesis in the rat Leydig cellsQ42170973
Protein kinase G-mediated stimulation of basal Leydig cell steroidogenesis.Q42518622
Sildenafil treatment in vivo stimulates Leydig cell steroidogenesis via the cAMP/cGMP signaling pathwayQ42955316
The brave new world of function-promoting anabolic therapies: testosterone and frailtyQ43172673
Structural complexity of the testis and PKG I / StAR interaction regulate the Leydig cell adaptive response to repeated immobilization stress.Q43205545
Effects of raloxifene on gonadotrophins, sex hormones, bone turnover and lipids in healthy elderly men.Q44841329
P433issue2
P921main subjectpharmacologyQ128406
hydroxysteroidQ2157080
testosteroneQ1318776
steroid biosynthetic processQ14358855
testosteroneQ27863114
P304page(s)397-407
P577publication date2011-04-06
P1433published inToxicological SciencesQ2446966
P1476titlePharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats
P478volume121

Reverse relations

cites work (P2860)
Q36640291Acute effects of hexabromocyclododecane on Leydig cell cyclic nucleotide signaling and steroidogenesis in vitro
Q53688645Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review.
Q33593528Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteum
Q44141439Effect of exogenous testosterone on oxidative status of the testes in adult male rats
Q37340570Effects of Nandrolone Stimulation on Testosterone Biosynthesis in Leydig Cells
Q51675481Elevated expression of the Sertoli cell androgen receptor disrupts male fertility.
Q28383987In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment
Q90248321Mancozeb impaired male fertility in rabbits with trials of glutathione detoxification
Q41241192Nandrolone decanoate interferes with testosterone biosynthesis altering blood-testis barrier components.
Q42520784Orally applied doxazosin disturbed testosterone homeostasis and changed the transcriptional profile of steroidogenic machinery, cAMP/cGMP signalling and adrenergic receptors in Leydig cells of adult rats.
Q44306248Progesterone increases ex vivo testosterone production and decreases the expression of progestin receptors and steroidogenic enzymes in the fathead minnow (Pimephales promelas) ovary
Q37225078Regulation of 3β-hydroxysteroid dehydrogenase/Δ⁵-Δ⁴ isomerase: a review
Q43625516Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells

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