T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.

scientific article published on 16 January 2007

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20062259
P932PMC publication ID2118414
P698PubMed publication ID17227914
P5875ResearchGate publication ID6574560

P50authorShimon SakaguchiQ17502433
Yoichiro IwakuraQ56564114
Tomoyuki YamaguchiQ58805272
Keiji HirotaQ64516357
P2093author name stringSatoshi Tanaka
Hiroyuki Yoshitomi
Motomu Hashimoto
Takashi Nomura
Noriko Sakaguchi
P2860cites workZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chainQ24294340
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritisQ28267921
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variantQ28280659
Interleukin-17 family members and inflammationQ28287876
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationQ29547525
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammationQ29614224
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
Evolving concepts of rheumatoid arthritisQ29618020
Monogenic autoimmune diseases - lessons of self-toleranceQ36286981
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible miceQ36403371
Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in miceQ37286418
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.Q42767100
Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responsesQ44158655
Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1Q56899149
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in miceQ59069058
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)41-47
P577publication date2007-01-16
P1433published inJournal of Experimental MedicineQ3186912
P1476titleT cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
P478volume204

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