Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+.

scientific article published on 13 April 2011

Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.187138
P932PMC publication ID3122168
P698PubMed publication ID21489985

P50authorCatherine J PearsQ59248425
Paul GissenQ60647294
Amanda J UnsworthQ63410225
Steve P. WatsonQ37383398
P2093author name stringHolly Smith
P2860cites workDirect Demonstration of Involvement of Protein Kinase Cα in the Ca2+-induced Platelet AggregationQ24300892
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Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosisQ27863317
Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretionQ28140801
Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human plateletsQ50335784
A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAFQ57979415
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Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human plateletsQ71001166
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Protein kinase C activates the plasma membrane Ca2+ pump isoform 4b by phosphorylation of an inhibitory region downstream of the calmodulin-binding domainQ71833739
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Concomitant activation of Gi protein-coupled receptor and protein kinase C or phospholipase C is required for platelet aggregationQ73203586
Molecular Basis of Platelet Granule SecretionQ73372406
Activation of ADP receptors and platelet functionQ73447393
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Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activationQ28193702
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PKCalpha regulates platelet granule secretion and thrombus formation in miceQ28505136
Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infectionQ28594768
Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human plateletsQ28609210
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Go6976 abrogates GPVI-mediated platelet functional responses in human platelets through inhibition of SykQ33798496
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Protein kinase C[delta] differentially regulates platelet functional responsesQ37344199
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Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets.Q41191812
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Mechanism of activation and functional role of protein kinase Ceta in human plateletsQ42087887
Inhibition of protein kinase C by staurosporine promotes elevated accumulations of inositol trisphosphates and tetrakisphosphate in human platelets exposed to thrombinQ42196933
Protein kinase C alpha enhances sodium–calcium exchange during store-operated calcium entry in mouse plateletsQ42795655
Feedback regulation of phospholipase C-beta by protein kinase C.Q42831016
Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in plateletsQ43701621
Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxinQ43770098
Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptorsQ43833415
Adenosine diphosphate(ADP) does not induce thromboxane A2 generation in human plateletsQ43995974
Phosphorylation of SNAP-23 in activated human plateletsQ44557666
Differential Role of Protein Kinase Cδ Isoform in Agonist-induced Dense Granule Secretion in Human PlateletsQ44631925
Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets.Q44928920
PKCtheta in platelet activation.Q45933605
Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.Q46849080
Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets.Q50318700
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)21073-21082
P577publication date2011-04-13
P1433published inJournal of Biological ChemistryQ867727
P1476titleSubmaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+.
P478volume286

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cites work (P2860)
Q5089312512-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.
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Q100944049Is there a relationship between morphological and functional platelet changes and depressive disorder?
Q41880839Non-additive interactions between mitochondrial complex IV blockers and hypoxia in rat carotid body responses
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Q42324464Platelets and atherogenesis: Platelet anti-aggregation activity and endothelial protection from tomatoes (Solanum lycopersicum L.).
Q50437554Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395.
Q35903389Protein kinase C isoform ε negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets
Q35776733Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation
Q36494948Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.
Q35863108The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation

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