MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.

scientific article published on May 1996

MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.271.22.13234
P698PubMed publication ID8662753
P5875ResearchGate publication ID14537655

P50authorShigeo OhnoQ37369831
Shin-Ichi OsadaQ56000588
P2093author name stringJ Inoue
S Hirai
T Aoki
M Hirano
M Hosaka
P2860cites workJNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activationQ24316905
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathwayQ24321670
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1Q28114883
The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimersQ28260566
A divergence in the MAP kinase regulatory network defined by MEK kinase and RafQ28263195
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathwayQ28615706
Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa BQ28615800
Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa BQ28615810
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa BQ28615823
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activationQ28776205
Function and activation of NF-kappa B in the immune systemQ29547790
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylationQ29614709
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa BQ29618193
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activityQ29618284
An inducible transcription factor activates expression of human immunodeficiency virus in T cellsQ29618434
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKKQ29620274
Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophagesQ34637334
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alphaQ36180990
Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complexQ36582453
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activationQ36694624
BK viral enhancer element and a human cellular homologQ40138318
Involvement of a cis-element that binds an H2TF-1/NF kappa B like factor(s) in the virus-induced interferon-beta gene expressionQ40449231
A protein kinase C isozyme, nPKC epsilon, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblastsQ41381819
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes.Q41808247
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.Q45971622
A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C familyQ48321376
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P1104number of pages5
P304page(s)13234-13238
P577publication date1996-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleMEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha
P478volume271