Hypertension Promotes Phosphorylation of Focal Adhesion Kinase and Proline-Rich Tyrosine Kinase 2 in Rats: Implication for the Pathogenesis of Hypertensive Vascular Disease

scientific article published on November 1, 2010

Hypertension Promotes Phosphorylation of Focal Adhesion Kinase and Proline-Rich Tyrosine Kinase 2 in Rats: Implication for the Pathogenesis of Hypertensive Vascular Disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1620/TJEM.222.201
P953full work available at URLhttp://www.jstage.jst.go.jp/article/tjem/222/3/222_3_201/_pdf
https://www.jstage.jst.go.jp/article/tjem/222/3/222_3_201/_pdf
P698PubMed publication ID21068519

P50authorHiroaki ShimokawaQ89249388
P2093author name stringKunio Shirato
Huan Wang
Koichiro Sugimura
Yoshihiro Fukumoto
Tomohiro Tada
Jun Nawata
Noriko Onoue
P2860cites workSignal transduction of mechanical stresses in the vascular wallQ77156091
Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in miceQ79758199
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-SrcQ24320223
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assemblyQ24642753
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteinsQ24647075
Atherosclerosis — An Inflammatory DiseaseQ26776972
Integrin signalingQ28142010
Signaling through focal adhesion kinaseQ28198051
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migrationQ28369093
Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinaseQ30442141
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal modelsQ33825979
RAFTK/Pyk2-mediated cellular signallingQ33855347
Mechanical stress-initiated signal transductions in vascular smooth muscle cellsQ34034099
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseasesQ34542649
Endothelial responses to mechanical stress: where is the mechanosensor?Q34633527
Role of integrins in endothelial mechanosensing of shear stressQ34986187
Stabilization of atherosclerotic plaques: new mechanisms and clinical targetsQ34986368
Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and functionQ36124533
Comparison of blood vessel wall dimensions in normotensive hypertensive rats by histometric and morphometric methods.Q36634824
Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitorsQ36780496
Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functionsQ36985032
The role of cell adhesion pathways in angiogenesis.Q37257956
Mechanism of angiotensin II-mediated regulation of fibronectin gene in rat vascular smooth muscle cellsQ38332881
Replication of smooth muscle cells in vascular diseaseQ39731571
Spatial and temporal regulation of focal adhesion kinase activity in living cells.Q40060648
Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cellsQ40929976
Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cellsQ41108928
Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chainQ41199325
Focal adhesion kinase is involved in angiotensin II-mediated protein synthesis in cultured vascular smooth muscle cellsQ42494475
Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscleQ42515619
Src autophosphorylation is an early event in pressure-mediated signaling pathways in isolated resistance arteriesQ43908236
Activation of Cell Adhesion Kinase β by Mechanical Stretch in Vascular Smooth Muscle CellsQ44440493
Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytesQ44477120
Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.Q45933507
Colchicine, a microtubule depolymerizing agent, inhibits myocardial apoptosis in ratsQ46965527
The upregulation of ICAM-1 and P-selectin requires high blood pressure but not circulating renin-angiotensin system in vivoQ47331782
Fibronectin expression and aortic wall elastic modulus in spontaneously hypertensive ratsQ47810226
Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques.Q53884073
Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigsQ73028965
Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigsQ73124801
Mechanical strain increases protein tyrosine phosphorylation in airway smooth muscle cellsQ74378380
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P1104number of pages10
P304page(s)201-210
P577publication date2010-11-01
P1433published inTohoku Journal of Experimental MedicineQ15766613
P1476titleHypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease
Hypertension Promotes Phosphorylation of Focal Adhesion Kinase and Proline-Rich Tyrosine Kinase 2 in Rats: Implication for the Pathogenesis of Hypertensive Vascular Disease
P478volume222

Reverse relations

cites work (P2860)
Q36286471Phospholipid binding to the FAK catalytic domain impacts function.
Q41889741Src modulates contractile vascular smooth muscle function via regulation of focal adhesions
Q30357240The mTOR-FAK mechanotransduction signaling axis for focal adhesion maturation and cell proliferation.

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