Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38.

scientific article published on June 2004

Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BRAINRES.2004.03.018
P698PubMed publication ID15140644

P2093author name stringDonard S Dwyer
Ronald J Bradley
Xiao-Hong Lu
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)58-68
P577publication date2004-06-01
P1433published inBrain ResearchQ4955782
P1476titleOlanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38.
P478volume1011

Reverse relations

cites work (P2860)
Q46441373A comparative study of beta-amyloid peptides Abeta1-42 and Abeta25-35 toxicity in organotypic hippocampal slice cultures
Q33926752Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release
Q39922746Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907.
Q37139258Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway
Q42185376Antipsychotic drugs activate the C. elegans akt pathway via the DAF-2 insulin/IGF-1 receptor
Q40312591Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells.
Q40365362Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases
Q30386608Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
Q50440426Aripiprazole protects cortical neurons from glutamate toxicity
Q51246446Association of Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder.
Q35852767Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine.
Q22252332Bipolar disorder and mechanisms of action of mood stabilizers
Q33764262Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt
Q54576279Clozapine and lithium require Caenorhabditis elegans β-arrestin and serum- and glucocorticoid-inducible kinase to affect Daf-16 (FOXO) localization.
Q51102233Clozapine as the most efficacious antipsychotic for activating ERK 1/2 kinases: Role of 5-HT2A receptor agonism.
Q48881589Clozapine induction of ERK1/2 cell signalling via the EGF receptor in mouse prefrontal cortex and striatum is distinct from other antipsychotic drugs
Q46092553Clozapine-induced ERK1 and ERK2 signaling in prefrontal cortex is mediated by the EGF receptor.
Q48441064Differential effects of haloperidol and olanzapine on the expression of erythropoietin and its receptor in rat hippocampus and striatum
Q34660464Docosahexaenoic Acid Suppresses Neuroinflammatory Responses and Induces Heme Oxygenase-1 Expression in BV-2 Microglia: Implications of Antidepressant Effects for Omega-3 Fatty Acids
Q38177357Drug discovery based on genetic and metabolic findings in schizophrenia
Q27693888Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs
Q39851823Early effects of mood stabilizers on the Akt/GSK-3beta signaling pathway and on cell survival and proliferation
Q34576434Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys
Q54525405Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells.
Q36687842Evidence for neuroprotective effects of antipsychotic drugs: implications for the pathophysiology and treatment of schizophrenia
Q38060893Improving myelin/oligodendrocyte-related dysfunction: a new mechanism of antipsychotics in the treatment of schizophrenia?
Q51802385In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling.
Q39327912Interferon-α induces nitric oxide synthase expression and haem oxygenase-1 down-regulation in microglia: implications of cellular mechanism of IFN-α-induced depression
Q36248058Mechanistic connections between glucose/lipid disturbances and weight gain induced by antipsychotic drugs
Q101403037N-acetylcysteine prevents olanzapine-induced oxidative stress in mHypoA-59 hypothalamic neurons
Q34662630Neurogenic actions of atypical antipsychotic drugs and therapeutic implications
Q33267049Neuroprotection and enhancement of neurite outgrowth with small molecular weight compounds from screens of chemical libraries
Q41950823Olanzapine Reversed Brain Gene Expression Changes Induced by Phencyclidine Treatment in Non-Human Primates
Q40380108Olanzapine impairs glycogen synthesis and insulin signaling in L6 skeletal muscle cells.
Q48142941Olanzapine potentiates neuronal survival and neural stem cell differentiation: regulation of endoplasmic reticulum stress response proteins
Q36606052Possible mechanisms of neurodegeneration in schizophrenia.
Q33238062Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation
Q40045402Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells
Q34993652Structure-based discovery of low molecular weight compounds that stimulate neurite outgrowth and substitute for nerve growth factor
Q48790631The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect
Q38189780The emerging role of dopamine-glutamate interaction and of the postsynaptic density in bipolar disorder pathophysiology: Implications for treatment
Q33583992The neurotrophic and neuroprotective effects of psychotropic agents.
Q42176718α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation

Search more.