Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor

scientific article published on June 2001

Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/BIT.1071
P698PubMed publication ID11320508

P2093author name stringToner M
Roy P
Yarmush ML
Tilles AW
Baskaran H
P433issue5
P921main subjectbioreactorQ864699
P304page(s)379-389
P577publication date2001-06-01
P1433published inBiotechnology and BioengineeringQ4915339
P1476titleEffects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor
P478volume73

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cites work (P2860)
Q389476183D Cultivation Techniques for Primary Human Hepatocytes
Q584838003D cellular invasion platforms: how do paper-based cultures stack up?
Q41822576A Scalable Perfusion Culture System with Miniature Peristaltic Pumps for Live-Cell Imaging Assays with Provision for Microfabricated Scaffolds
Q28607717A Tubing-Free Microfluidic Wound Healing Assay Enabling the Quantification of Vascular Smooth Muscle Cell Migration
Q35446580A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats
Q41845201A microfluidic hepatic coculture platform for cell-based drug metabolism studies
Q55249382A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines.
Q48100667A pump-free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte-like cells
Q57635754A thin-walled polydimethylsiloxane bioreactor for high-density hepatocyte sandwich culture
Q48310721A vertical-flow bioreactor array compacts hepatocytes for enhanced polarity and functions.
Q35010089A whole-organ regenerative medicine approach for liver replacement
Q51505217An on-chip small intestine-liver model for pharmacokinetic studies.
Q39643700Analysis of chemoresistance in lung cancer with a simple microfluidic device
Q42077898Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device
Q55256317Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies.
Q38130163Bioengineered sites for islet cell transplantation
Q47093789Bioengineering considerations in liver regenerative medicine.
Q37074508Biomimetic approaches to control soluble concentration gradients in biomaterials
Q34087508Bioreactor technologies to support liver function in vitro.
Q50083646Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells.
Q48215811CFD assessment of the effect of convective mass transport on the intracellular clearance of intracellular triglycerides in macrosteatotic hepatocytes.
Q37295430Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device
Q57458850Caring for cells in microsystems: principles and practices of cell-safe device design and operation
Q38230357Cell and tissue engineering for liver disease
Q92542002Challenges and Opportunities in the Design of Liver-on-Chip Microdevices
Q40165096Characterizing doxorubicin-induced apoptosis in HepG2 cells using an integrated microfluidic device
Q36625231Coencapsulation of hepatocytes and bone marrow cells: in vitro and in vivo studies
Q51088952Comparison of the transcriptomic profile of hepatic human induced pluripotent stem like cells cultured in plates and in a 3D microscale dynamic environment.
Q44630182Computational fluid modeling and performance analysis of a bidirectional rotating perfusion culture system.
Q50916795Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems.
Q39140425Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?
Q37694755Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates
Q39445503Development of a double-layer microfluidic chip with flow medium for chemotherapy resistance analysis of lung cancer
Q49504268Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.
Q33675139Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform.
Q42168257Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure
Q38799238Emerging In Vitro Liver Technologies for Drug Metabolism and Inter-Organ Interactions
Q50913396Engineered bone culture in a perfusion bioreactor: a 2D computational study of stationary mass and momentum transport.
Q34599566Engineered three-dimensional liver mimics recapitulate critical rat-specific bile acid pathways
Q37655140Engineering a perfusable 3D human liver platform from iPS cells
Q50862341Enhanced oxygen availability improves liver-specific functions of the AMC bioartificial liver.
Q48014053Enhanced oxygen delivery to primary hepatocytes within a hollow fiber bioreactor facilitated via hemoglobin-based oxygen carriers
Q47342620Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips.
Q40485177Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling
Q41901808Fluid shear stress modulation of hepatocyte-like cell function.
Q28486232Functional investigation of NCI-H460-inducible myofibroblasts on the chemoresistance to VP-16 with a microfluidic 3D co-culture device
Q42809993Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues
Q40965254Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor.
Q54123025Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes.
Q35018059Improving the next generation of bioartificial liver devices
Q58565205In vitro and ex vivo systems at the forefront of infection modeling and drug discovery
Q52057573In vitro and in vivo evaluation of albumin synthesis rate of porcine hepatocytes in a flat-plate bioreactor.
Q39788132In vitro liver model using microfabricated scaffolds in a modular bioreactor
Q36255237Intracellular nucleotide pools and ratios as tools for monitoring dedifferentiation of primary porcine hepatocytes in culture
Q50053252Investigation of expression and activity levels of primary rat hepatocyte detoxication genes under various flow rates and cell densities in microfluidic biochips.
Q48189580Lab on a chip-based hepatic sinusoidal system simulator for optimal primary hepatocyte culture
Q33829599Lensfree holographic imaging of antibody microarrays for high-throughput detection of leukocyte numbers and function
Q89976263Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective
Q41212888Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms
Q33950022Liver tissue engineering in the evaluation of drug safety
Q37193008Long-term culture and coculture of primary rat and human hepatocytes
Q47445929Long-term human primary hepatocyte cultures in a microfluidic liver biochip show maintenance of mRNA levels and higher drug metabolism compared with Petri cultures
Q64053349M2 macrophages promote NSCLC metastasis by upregulating CRYAB
Q51251252Mass transport and shear stress in a microchannel bioreactor: numerical simulation and dynamic similarity.
Q43471040Mechanical compaction directly modulates the dynamics of bile canaliculi formation
Q48172962Metabolic Oscillations in Co-Cultures of Hepatocytes and Mesenchymal Stem Cells: Effects of Seeding Arrangement and Culture Mixing.
Q55384558Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes.
Q39344014Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells.
Q35826421Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.
Q45924666Microfabrication of human organs-on-chips.
Q37844444Microfluidic devices for in vitro studies on liver drug metabolism and toxicity
Q37951402Microfluidic platforms for hepatocyte cell culture: new technologies and applications
Q30479257Micromechanical control of cell-cell interactions.
Q37313798Modeling nutrient consumptions in large flow-through bioreactors for tissue engineering.
Q35068949Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.
Q33499690Modulating temporal and spatial oxygenation over adherent cellular cultures
Q92968389Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making
Q35577829Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow.
Q30422227New tools and new biology: recent miniaturized systems for molecular and cellular biology
Q33449374Normal atmospheric oxygen tension and the use of antioxidants improve hepatocyte spheroid viability and function
Q90403546Numerical Investigations of Hepatic Spheroids Metabolic Reactions in a Perfusion Bioreactor
Q47661755Numerical simulation of mass transport in a microchannel bioreactor with cell micropatterning
Q41674026On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro
Q48004624Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer.
Q42151444Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate
Q51026271Optimized performance of the integrated hepatic cell-loaded cryogel-based bioreactor with intermittent perfusion of acute liver failure plasma.
Q38013255Organotypic systems in drug metabolism and toxicity: challenges and opportunities
Q36780735Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device
Q35009491Oxygen levels in thermoplastic microfluidic devices during cell culture.
Q37354141Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.
Q93031977Patterned Fibers Embedded Microfluidic Chips Based on PLA and PDMS for Ag Nanoparticle Safety Testing
Q39325864Perfusion flow rate substantially contributes to the performance of the HepaRG-AMC-bioartificial liver
Q93007105Primary Hepatocytes Cultured on a Fiber-Embedded PDMS Chip to Study Drug Metabolism
Q28834338Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction
Q51490801Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone.
Q37121662Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Q91869719Review: Mechanotransduction in ovarian cancer: Shearing into the unknown
Q28568945Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription
Q46665305Size-dependent interaction of cells and hemoglobin-albumin based oxygen carriers prepared using the SPG membrane emulsification technique
Q40223393Targeted oxygen delivery within hepatic hollow fiber bioreactors via supplementation of hemoglobin-based oxygen carriers
Q37967417The current status of alternatives to animal testing and predictive toxicology methods using liver microfluidic biochips
Q40592433The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors
Q30474413The design of in vitro liver sinusoid mimics using chitosan-hyaluronic acid polyelectrolyte multilayers
Q42955998The effectiveness of a novel cartridge-based bioreactor design in supporting liver cells
Q42833333The impact of fabrication parameters and substrate stiffness in direct writing of living constructs.
Q41488482Three-dimensional numerical modeling and computational fluid dynamics simulations to analyze and improve oxygen availability in the AMC bioartificial liver
Q34447374Tissue-Engineered Model for Real-Time Monitoring of Liver Inflammation

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