RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy

scientific article published on 20 November 2003

RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2003-07-2379
P698PubMed publication ID14630810
P5875ResearchGate publication ID8996747

P50authorStephan A GruppQ104495066
P2093author name stringRobert H Vonderheide
Barbara A Vance
Christina M Coughlin
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectimmunotherapyQ1427096
P304page(s)2046-2054
P577publication date2003-11-20
P1433published inBloodQ885070
P1476titleRNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy
P478volume103

Reverse relations

cites work (P2860)
Q56967539Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses
Q34909225Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice
Q35146131Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression
Q34243887Anti-GD2 Strategy in the Treatment of Neuroblastoma
Q34725758Antibody-based immunotherapy in high-risk neuroblastoma
Q64913188B Cell-Based Cancer Immunotherapy.
Q42969728B cell-regulated immune responses in tumor models and cancer patients
Q33632113B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment
Q35444346B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Q37069120B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice
Q44945891B cells contribute to the antitumor activity of CpG-oligodeoxynucleotide in a mouse model of metastatic lung carcinoma.
Q33684762B cells inhibit the antitumor immunity against an established murine fibrosarcoma
Q37928542B lymphocytes as effector cells in the immunotherapy of cancer
Q48371221CD40 Ligand-activated, antigen-specific B cells are comparable to mature dendritic cells in presenting protein antigens and major histocompatibility complex class I- and class II-binding peptides.
Q36022324CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.
Q34014497CD40-activated B cell cancer vaccine improves second clinical remission and survival in privately owned dogs with non-Hodgkin's lymphoma
Q38113268CD40-activated B cells as antigen-presenting cells: the final sprint toward clinical application
Q37336918CD40-activated B cells can be generated in high number and purity in cancer patients: analysis of immunogenicity and homing potential.
Q34145881CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells
Q43406455CD40-activated B cells contribute to mesothelioma tumor regression.
Q42742311CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants
Q34080118Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients.
Q34880734Characterization of the ribonuclease activity on the skin surface
Q33959343Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers
Q41773067Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell response
Q39966752Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia
Q37273700Design of CD40 agonists and their use in growing B cells for cancer immunotherapy
Q33785850Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay
Q53534873Efficient antitumor immunity in a murine colorectal cancer model induced by CEA RNA-electroporated B cells.
Q49039662Efficient gene transfer in CLL by mRNA electroporation.
Q37718429Efficient generation of antigen-specific CTLs by the BAFF-activated human B Lymphocytes as APCs: a novel approach for immunotherapy
Q50035982Electroporation of mRNA as Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins
Q34105724Enhancing T Cell Immune Responses by B Cell-based Therapeutic Vaccine Against Chronic Virus Infection.
Q40454655Ex vivo induction of viral antigen-specific CD8 T cell responses using mRNA-electroporated CD40-activated B cells.
Q35812007Ex vivo engineered immune organoids for controlled germinal center reactions
Q37271276Highlights of the First International "Immunotherapy in Pediatric Oncology: Progress and Challenges" Meeting
Q35101531Human T-cell responses to vaccinia virus envelope proteins.
Q37150312Immortalized B cells: a neverending source of antigen-presenting cells for vaccines?
Q47195254Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity
Q34616576Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors
Q40399099Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production.
Q27489354Immunogenicity of Human Mesenchymal Stem Cells in HLA-Class I-Restricted T-Cell Responses Against Viral or Tumor-Associated Antigens
Q36453273Immunotherapy of neuroblastoma: present, past and future.
Q35971029Immunotherapy targets in pediatric cancer
Q34541239Impact of CD68/(CD3+CD20) ratio at the invasive front of primary tumors on distant metastasis development in breast cancer
Q36539717Impaired tumor antigen processing by immunoproteasome-expressing CD40-activated B cells and dendritic cells
Q36628925In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins
Q37086932In vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy
Q37440696Induction of protective cytotoxic T-cell responses by a B-cell-based cellular vaccine requires stable expression of antigen.
Q40441002Inflammation enhances the vaccination potential of CD40-activated B cells in mice
Q45863477Interferon beta adenoviral gene therapy in a patient with ovarian cancer.
Q37439998Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo.
Q60342834Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Q37469720Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells
Q35842616Messenger RNA-based vaccines
Q34477358Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines
Q35936953Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK.
Q40002875RNA-loaded CD40-activated B cells stimulate antigen-specific T-cell responses in dogs with spontaneous lymphoma
Q36111911Regulators of apoptosis: suitable targets for immune therapy of cancer
Q34478042Soluble CD40 ligand-activated human peripheral B cells as surrogated antigen presenting cells: A preliminary approach for anti-HBV immunotherapy
Q35110486Tertiary Lymphoid Structure-Associated B Cells are Key Players in Anti-Tumor Immunity
Q88318271The Immune Revolution: A Case for Priming, Not Checkpoint
Q41761209The immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells
Q42489904The prognostic significance of B lymphocytes in invasive carcinoma of the breast.
Q35799028The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: A comprehensive analysis reveals prognostic immune markers
Q38026924The use of agonistic anti-CD40 therapy in treatments for cancer
Q43105000Tumor mRNA-transfected dendritic cells stimulate the generation of CTL that recognize neuroblastoma-associated antigens and kill tumor cells: immunotherapeutic implications
Q36413361Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals

Search more.