Protein-based blood substitutes: recent attempts at controlling pro-oxidant reactivity with and beyond hemoglobin

scientific article published on 4 July 2013

Protein-based blood substitutes: recent attempts at controlling pro-oxidant reactivity with and beyond hemoglobin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/PH6070867
P8608Fatcat IDrelease_bwhd3gjsazg7tev7qa3l53rxcm
P932PMC publication ID3816705
P698PubMed publication ID24276319
P5875ResearchGate publication ID258922767

P50authorRadu Silaghi-DumitrescuQ42776494
P2093author name stringAugustin C Moţ
Violeta-Florina Scurtu
P2860cites workGenetically crosslinked hemoglobin: a structural studyQ22254746
X-ray crystal structures of reduced rubrerythrin and its azide adduct: a structure-based mechanism for a non-heme diiron peroxidaseQ27639492
A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2transporterQ28190278
PEGylation, successful approach to drug deliveryQ28278538
Redox reactions of hemoglobin and myoglobin: biological and toxicological implicationsQ34276285
Oxygen carriers ("blood substitutes")--raison d'etre, chemistry, and some physiologyQ34466085
Oxygen therapeutics: can we tame haemoglobin?Q35712972
Reaction of haem containing proteins and enzymes with hydroperoxides: the radical viewQ36049137
Nature of the FeO2 bonding in myoglobin and hemoglobin: A new molecular paradigmQ36187427
All hemoglobin-based oxygen carriers are not created equallyQ37061124
A leucine residue "Gates" solvent but not O2 access to the binding pocket of phascolopsis gouldii hemerythrinQ38313626
Mechanisms of cooperativity and allosteric regulation in proteinsQ38692121
Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo.Q38739381
A mutation that improves soluble recombinant hemoglobin accumulation in Escherichia coli in heme excessQ39480431
Roles of hemoglobin Allostery in hypoxia-induced metabolic alterations in erythrocytes: simulation and its verification by metabolome analysis.Q51922652
Modulation of expression and polymerization of hemoglobin Polytaur, a potential blood substituteQ53408180
Artificial Oxygen Carriers: Renewed Commercial Interest and Scientific/Technological AdvancesQ58134654
ATP-hemoglobin: anomalous oxygen binding propertiesQ69026194
ATP-hemoglobin purification by ATP-agarose affinity chromatographyQ69643754
Modification of hemoglobin--ring opened dialsQ71808254
Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reactionQ74332512
Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol)-lipidsQ77292941
Structural basis for O2 sensing by the hemerythrin-like domain of a bacterial chemotaxis protein: substrate tunnel and fluxional N terminusQ79981989
Hemoglobin-albumin crosslinked copolymers: reduced prooxidant reactivityQ84219823
Derivatization of haemoglobin with periodate-generated reticulation agents: evaluation of oxidative reactivity for potential blood substitutesQ85229520
Towards hemerythrin-based blood substitutes: comparative performance to hemoglobin on human leukocytes and umbilical vein endothelial cells.Q39528482
A new polyethyleneglycol-derivatized hemoglobin derivative with decreased oxygen affinity and limited toxicityQ39619625
Initiation of lipid peroxidation in biological systemsQ39665870
Intrinsic toxicity of hemoglobin: how to counteract it.Q40006806
Ferryl haem protonation gates peroxidatic reactivity in globinsQ42776412
Towards the development of hemerythrin-based blood substitutes.Q43003847
Structural and redox behavior of OxyVita, a zero-linked polymeric hemoglobin: comparison with natural acellular polymeric hemoglobinsQ43144997
Hemoglobin-albumin cross-linking with disuccinimidyl suberate (DSS) and/or glutaraldehyde for blood substitutesQ43446334
Hemoglobin polymerized with a naturally occurring crosslinking agent as a blood substitute: in vitro and in vivo studies.Q44993377
Artificial cells with emphasis on cell encapsulation of genetically engineered cellsQ45890113
Control of oxidative reactions of hemoglobin in the design of blood substitutes: role of the ascorbate-glutathione antioxidant systemQ46141365
Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobinQ47857012
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P304page(s)867-880
P577publication date2013-07-04
P1433published inPharmaceuticalsQ15750667
P1476titleProtein-based blood substitutes: recent attempts at controlling pro-oxidant reactivity with and beyond hemoglobin
P478volume6

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cites work (P2860)
Q35995001Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
Q99578874Glutaraldehyde-Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models
Q50055459The Reaction of Oxy Hemoglobin with Nitrite: Mechanism, Antioxidant-Modulated Effect, and Implications for Blood Substitute Evaluation.

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