Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

scientific article published on September 1986

Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ2380501
P932PMC publication ID1147162
P698PubMed publication ID2432882
P5875ResearchGate publication ID20722992

P2093author name stringIrvine RF
Downes CP
Hawkins PT
P2860cites workStepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liverQ48600954
The structure of triphosphoinositide from beef brain.Q51225128
Isolation and separation of inositol phosphates from hydrolysates of rat tissuesQ51251575
Myo-inositol phosphates obtained by alkaline hydrolysis of beef brain phosphoinositide.Q51305489
Mitogens increase phosphorylation of phosphoinositides in thymocytesQ59098713
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphateQ70090331
A high-performance liquid chromatographic method to measure 32P incorporation into phosphorylated metabolites in cultured cellsQ70534413
Net calcium fluxes in rat parotid acinar cells: evidence for a hormone-sensitive calcium pool in or near the plasma membraneQ71597860
[Paper chromatography of inositol phosphates; use in study of hydrolytic degradation of inositol hexaphosphate]Q74208678
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositidesQ24529828
Inositol trisphosphate, a novel second messenger in cellular signal transductionQ29618048
The role of protein kinase C in cell surface signal transduction and tumour promotionQ29618532
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membraneQ34253544
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateQ34264314
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.Q34285327
Inositol lipids and cell stimulation in mammalian salivary glandQ40133381
Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glandsQ41882950
Alkaline O→N-transacylation. A new method for the quantitative deacylation of phospholipidsQ41991534
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slicesQ42066730
Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glandsQ42148281
Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphateQ42182959
Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cellsQ42252343
Inositol trisphosphates in carbachol-stimulated rat parotid glandsQ42848200
Sympathetic denervation impairs agonist-stimulated phosphatidylinositol metabolism in rat parotid glandsQ42865273
Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cellsQ42867000
P433issue2
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)501-506
P577publication date1986-09-01
P1433published inBiochemical JournalQ864221
P1476titleInositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland
P478volume238

Reverse relations

cites work (P2860)
Q481095735-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in the mouse cortex has pharmacological characteristics compatible with mediation via 5-HT2 receptors but this response does not reflect altered 5-HT2 function after 5,7-dihydroxytrypta
Q68463949A central role for phosphoinositide hydrolysis in activating the lytic mechanism of human natural killer cells
Q41934073A low-affinity, low-molecular-mass endothelin-A receptor in neonatal rat heart
Q42091416A novel approach to detect toxin-catalyzed ADP-ribosylation in intact cells: its use to study the action of Pasteurella multocida toxin
Q41989793A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells
Q41981161A rapid separation method for inositol phosphates and their isomers
Q42836270A simple enzymic method to separate [3H]inositol 1,4,5- and 1,3,4-trisphosphate isomers in tissue extracts
Q44610185Accumulation of [3H]-inositol into inositol polyphosphates during development of Dictyostelium
Q28616287Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate
Q41810656An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes
Q46937018Analysis of phosphoinositides and their aqueous metabolites
Q67491294Angiotensin II and acetylcholine differentially activate mobilization of inositol phosphates in Xenopus laevis ovarian follicles
Q34358607Calcium messenger system in plants
Q35874250Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices
Q35027541Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors
Q49010955Characterization of the quisqualate receptor linked to phosphoinositide hydrolysis in neurocortical cultures
Q24561921Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
Q67915859Comparative studies of D-myoinositol 1,4,5-trisphosphate and synthetic 6-deoxy D-myoinositol 1,4,5-trisphosphate: Binding and calcium release activity in rat parotid microsomes
Q42026442Convulxin-induced platelet aggregation is accompanied by a powerful activation of the phospholipase C pathway
Q34378631Coupling of inositol phospholipid hydrolysis to peptide hormone receptors expressed from adrenal and pituitary mRNA in Xenopus laevis oocytes
Q35873343Cyclic AMP-elevating agents prolong or inhibit eosinophil survival depending on prior exposure to GM-CSF
Q41904079D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor
Q45039496Demonstration of inositol 1,3,4,5-tetrakisphosphate receptor binding
Q34163331Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate
Q41830562Desensitization of histamine H1 receptor-mediated inositol phosphate production in HeLa cells
Q42228489Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle
Q42162458Differences between muscarinic-receptor- and Ca2(+)-induced inositol polyphosphate isomer accumulation in rat cerebral-cortex slices
Q46645103Does the inositol tris/tetrakisphosphate pathway exist in rat heart?
Q41391761EGF receptor-mediated signals are differentially modulated by concanavalin A.
Q42822014Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D.
Q36235305Effects of CapG overexpression on agonist-induced motility and second messenger generation.
Q42804987Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells.
Q42582502Effects of purinoceptor agonists on cytosolic Ca2+ concentration in swine tracheal smooth muscle cells in culture
Q28253108Evidence for at least four different inositol bisphosphatases in bovine brain
Q24562796Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes
Q35592844Focal adhesion kinase promotes phospholipase C-gamma1 activity.
Q36460706Formation and metabolism of inositol 1,4,5-trisphosphate in human platelets
Q41914793Formation of inositol phosphate isomers in GH3 pituitary tumour cells stimulated with thyrotropin-releasing hormone. Acute effects of lithium ions
Q48826855Functional characterisation of alpha 1-adrenoceptor subtypes mediating noradrenaline-induced inositol phosphate formation in rat thalamus slices
Q48789103Galanin Reduces Carbachol Stimulation of Phosphoinositide Turnover in Rat Ventral Hippocampus by Lowering Ca2+Influx Through Voltage-Sensitive Ca2+Channels
Q41809159Granulocyte/macrophage colony-stimulating factor affects myo-inositol metabolism in a novel manner. Implications for its priming action on human neutrophils
Q41334541Guanine nucleotides stimulate polyphosphoinositide phosphodiesterase and exocytotic secretion from HL60 cells permeabilized with streptolysin O.
Q40787449Histamine H(1) receptor activation inhibits the proliferation of human prostatic adenocarcinoma DU-145 cells
Q42528887Histamine H1 receptor activation stimulates [3H]GABA release from human astrocytoma U373 MG cells
Q42058015Histamine-induced inositol phosphate accumulation in HeLa cells: lithium sensitivity
Q41817112Homologous desensitization of substance-P-induced inositol polyphosphate formation in rat parotid acinar cells
Q48543529Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptor mechanisms
Q70178031Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes
Q28202351Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors
Q39094564Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling
Q49116585Increased intracellular calcium stimulates 3H-inositol polyphosphate accumulation in rat cerebral cortical slices
Q50533114Induction of cytosolic Ca2+ elevation mediated by Mas-7 occurs through membrane pore formation.
Q42855767Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands
Q42223998Inositol 1,3,4,5-tetrakisphosphate stimulates calcium release from bovine adrenal microsomes by a mechanism independent of the inositol 1,4,5-trisphosphate receptor
Q34368130Inositol 1,4,5-trisphosphate binds to a specific receptor and releases microsomal calcium in the anterior pituitary gland
Q42858201Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells.
Q42829220Inositol trisphosphate metabolism in Saccharomyces cerevisiae: identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase
Q33572609Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover
Q37492618Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors
Q46236286Interleukin-one induced inositol phospholipid breakdown in murine macrophages: possible mechanism of receptor activation
Q24529505L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase
Q41918969L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells
Q35871557Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle
Q46720739Leukotriene D4 increases both the force of contraction and polyphosphoinositide formation in guinea-pig papillary muscle
Q42857894Long-term atropine treatment lowers the efficacy of carbachol to stimulate phosphatidylinositol breakdown in the cerebral cortex and hippocampus of rats
Q42067723Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate
Q24529500Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate
Q41841833Metabolism of inositol 1,4,5-trisphosphate in permeabilized rat aortic smooth-muscle cells. Dependence on calcium concentration
Q35872913Mode of action of thrombin in the rabbit aorta
Q41641749Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase C gamma 1.
Q41759960Muscarinic receptors coupled to phosphoinositide hydrolysis and elevated cytosolic calcium in a human neuroblastoma cell line SK-N-SH.
Q35755523Noradrenaline stimulation of the phosphoinositide system: evidence for a novel hydrophobic inositol-containing compound in resistance arterioles
Q73049368Noradrenaline-induced inositol phosphate formation in rat striatum is mediated by alpha 1A-adrenoceptors
Q39020690Over-expression of Brassica napus phosphatidylinositol-phospholipase C2 in canola induces significant changes in gene expression and phytohormone distribution patterns, enhances drought tolerance and promotes early flowering and maturation
Q42823712Pancreatic acinar-cell desensitization alters InsP3 production and Ca2+ mobilization under conditions where InsP3 receptor remains intact
Q34611793Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism
Q46174186Phorbol esters modulate the high Ca2(+)-stimulated accumulation of inositol phosphates in bovine parathyroid cells
Q34427650Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts
Q40110300Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen
Q41834535Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [3H]R-(-)-rolipram binding by selective inhibitors
Q42142291Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages
Q41116788Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase
Q68277954Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells
Q42451700Possible existence of two subsets of platelet-activating factor receptor to mediate polyphosphoinositide breakdown and calcium influx in neuroblastoma x glioma hybrid NG 108-15 cells
Q48263881Potassium depolarisation markedly enhances muscarinic receptor stimulated inositol tetrakisphosphate accumulation in rat cerebral cortical slices
Q44238173Potentiation by gamma-aminobutyric acid of alpha 1-agonist-induced accumulation of inositol phosphates in slices of rat cerebral cortex
Q68284979Proceedings of the British Pharmacological Society. 6th-8th January, 1988. Abstracts
Q43609237Proctolin in the innervation of the locust mandibular closer muscle modulates contractions through the elevation of inositol trisphosphate
Q41819868Purification and properties of inositol-1,4-bisphosphatase from bovine brain
Q42182959Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate
Q67924324Rapid increase in inositol phosphate levels in norepinephrine-stimulated vascular smooth muscle
Q39601196Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes
Q41106133Regulation of the function of P-glycoprotein by epidermal growth factor through phospholipase C.
Q67990556Role of protein phosphorylation and inositol phospholipid turnover in rat parotid gland proliferation
Q39544550Second messengers and the regulation of Ca2+ fluxes by Ca2+-mobilizing agonists in rat liver
Q69364093Serotonin-stimulated biochemical events in the procerebrum of Limax
Q41025939Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells
Q47802178Signal transduction in the platelet activation induced by IgG anti-streptokinase and anisoylated plasminogen-streptokinase activator complex
Q71815409Staurosporine inhibits inositol phosphate formation in bovine adrenal medullary cells
Q41335715Stimulation of formation of inositol phosphates in primary cultures of bovine adrenal chromaffin cells by angiotensin II, histamine, bradykinin, and carbachol
Q48675859Stimulatory and inhibitory effects of N-methyl-D-aspartate on 3H-inositol polyphosphate accumulation in rat cortical slices
Q58214001Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells
Q34599531Synthesis of inositol 1,2-(cyclic)-4,5-trisphosphate
Q41093301Tachykinin-stimulated inositol phospholipid hydrolysis and taurine release from human astrocytoma cells
Q41892798The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells
Q42857083The dephosphorylation pathway of D-myo-inositol 1,3,4,5-tetrakisphosphate in rat brain
Q41790721The effects of noradrenaline and adenosine 5'-triphosphate on polyphosphoinositide and phosphatidylcholine hydrolysis in arterial smooth muscle
Q42279819The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells
Q42848194The interaction of benzodiazepines with thyrotropin-releasing hormone receptors on clonal pituitary cells
Q72139610The sigma compounds 1,3-di-o-tolylguanidine and N-allylnormetazocine inhibit agonist-stimulated inositol phospholipid metabolism in bovine adrenal medullary cells
Q41656954The thapsigargin-sensitive intracellular Ca2+ pool is more important in plasma membrane Ca2+ entry than the IP3-sensitive intracellular Ca2+ pool in neuronal cell lines
Q77631236The versatility of inositol phosphates as cellular signals
Q42516679Thrombin-stimulated elevation of human endothelial-cell cytoplasmic free calcium concentration causes prostacyclin production
Q42857046Thyroid-stimulating hormone stimulates increases in inositol phosphates as well as cyclic AMP in the FRTL-5 rat thyroid cell line
Q43946942Tumor promoter 12-O-tetradecanoylphorbol 13-acetate inhibits mas/angiotensin receptor-stimulated inositol phosphate production and intracellular Ca2+ elevation in the 401L-C3 neuronal cell line
Q42857277Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin
Q45099645Two Ca2+ transport systems are distinguished on the basis of their Mg2+ dependency in a post-nuclear particulate fraction of bovine adrenal cortex
Q36967818Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells
Q48595743Variation of InsP(4),InsP(5) and InsP(6) levels in tissues and biological fluids depending on dietary phytate
Q36329807Vascular mode of action of kinin B1 receptors and development of a cellular model for the investigation of these receptors
Q41830899gamma-Aminobutyric acid inhibition of histamine-induced inositol phosphate formation in guinea-pig cerebellum: comparison with guinea-pig and rat cerebral cortex

Search more.