Fatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepatocytes

scientific article published on October 15, 1983

Fatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepatocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ2160129
P953full work available at URLhttps://europepmc.org/articles/pmc1152479?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6316933/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6316933/pdf/?tool=EBI
https://europepmc.org/articles/PMC1152479
https://europepmc.org/articles/PMC1152479?pdf=render
https://portlandpress.com/biochemj/article-pdf/216/1/129/579071/bj2160129.pdf
P932PMC publication ID1152479
P698PubMed publication ID6316933
P5875ResearchGate publication ID16879218

P2093author name stringD. N. Brindley
S. L. Pelech
D. E. Vance
P. H. Pritchard
P2860cites workEffect of Different Fatty Acids on Glycerolipid Synthesis in Isolated Rat HepatocytesQ69812328
Inhibition of phosphatidylethanolamine N-methylation by 3-deazaadenosine stimulates the synthesis of phosphatidylcholine via the CDP-choline pathwayQ70340048
Synthesis and secretion of very low density lipoproteins by isolated rat hepatocytes in suspension: role of diacylglycerol acyltransferaseQ70862551
Synthesis of phospholipids and triglycerides in human liver slices. I. Experimental conditions and the synthesis rate in normal liver tissueQ71304084
cAMP analogues inhibit phosphatidylcholine biosynthesis in cultured rat hepatocytesQ72641534
Activation of phospholipid methyltransferase by glucagon in rat hepatocytesQ72862604
Regulation of phosphatidylcholine biosynthesis in cultured chick embryonic muscle treated with phospholipase CQ72868823
Evidence for a regulatory role of CTP : Choline phosphate cytidylyltransferase in the synthesis of phosphatidylcholine in fetal lung following premature birthQ72908166
Analogues of cyclic AMP inhibit phosphatidylethanolamine N-methylation by cultured rat hepatocytesQ72914243
Apparent phosphorylation - dephosphorylation of soluble phosphatidic acid phosphatase in rat liverQ72935279
Antagonistic effects of insulin on the corticosterone‐induced increase of phosphatidate phosphohydrolase activity in isolated rat hepatocytesQ72950496
UTILIZATION OF FATTY ACIDS BY RAT LIVER SLICES AS A FUNCTION OF MEDIUM CONCENTRATIONQ76721407
Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substratesQ28203079
Regulation of triacylglycerol synthesis in the liver: a decrease in diacylglycerol acyltransferase activity after treatment of isolated rat hepatocytes with glucagonQ28609523
Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitroQ28609535
Regulation of hepatic fatty acid oxidation and ketone body productionQ34248852
Short-term Hormonal Control of Hepatic LipogenesisQ40083340
Differential utilization of 1-palmitoyl and 1-stearoyl homologues of various unsaturated 1,2-diacyl-sn-glycerols for phosphatidylcholine and phosphatidylethanolamine synthesis in rat liver microsomesQ40123892
Lipolysis of hepatic triacylglycerol storesQ40129756
Acyl chain length dependency of diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase. Effect of different saturated fatty acids at the C-1 or C-2 position of diacylglycerol on solubilized rat liver microsomal enQ40159852
Very low density lipoprotein synthesis and secretion by cultured rat hepatocytesQ40211215
Induction of hepatic tyrosine aminotransferase in vivo by derivatives of cyclic adenosine 3':5'-monophosphateQ40309312
Regulation of hepatic triacylglycerol synthesis and lipoprotein metabolism by glucocorticoidsQ40311310
A sensitive radioenzymatic assay for glycerol and acylglycerolsQ40774034
In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesisQ41739682
Glucagon inhibits triacylglycerol synthesis in isolated hepatocytes by lowering their glycerol 3-phosphate contentQ42200875
Regulation of phosphatidylcholine biosynthesis in mammalian cells. II. Effects of phospholipase C treatment on the activity and subcellular distribution of CTP:phosphocholine cytidylyltransferase in Chinese hamster ovary and LM cell linesQ42452650
Variations in tissue contents of coenzyme A thio esters and possible metabolic implicationsQ42974663
A mild procedure for the rapid release of cytoplasmic enzymes from cultured animal cellsQ44277705
Influence of glucagon on the synthesis of phosphatidylcholines and phosphatidylethanolamines in monolayer cultures of Rat hepatocytesQ44765153
Choline metabolism and phosphatidylcholine biosynthesis in cultured rat hepatocytesQ45893733
Regulation of hepatic fatty acid metabolism. The activities of mitochondrial and microsomal acyl-CoA:sn-glycerol 3-phosphate O-acyltransferase and the concentrations of malonyl-CoA, non-esterified and esterified carnitine, glycerol 3-phosphate, ketoQ46594644
Analogues of adenosine 3',-5'-cyclic phosphate as activators of phosphorylase b kinase and as substrates for cyclic 3',5'-nucleotide phosphodiesteraseQ48955512
Regulation of rat liver cytosolic CTP: phosphocholine cytidylyltransferase by phosphorylation and dephosphorylationQ67235634
Regulation of phosphatidylcholine biosynthesis in mammalian cells. III. Effects of alterations in the phospholipid compositions of Chinese hamster ovary and LM cells on the activity and distribution of CTP:phosphocholine cytidylyltransferaseQ67257209
Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesisQ67295523
Influence of insulin and glucagon on the synthesis of glycerolipids in rat hepatocytesQ67341126
Reciprocal relationship between uptake of Ca++ and biosynthesis of glycerolipids from sn-glycerol-3-phosphate by rat liver microsomesQ67690651
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
cell biologyQ7141
phosphatidylcholineQ650187
P304page(s)129-136
P577publication date1983-10-01
1983-10-15
P1433published inBiochemical JournalQ864221
P1476titleFatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepatocytes
P478volume216

Reverse relations

cites work (P2860)
Q417388731,2-Diacylglycerols overcome cyclic AMP-mediated inhibition of phosphatidylcholine synthesis in GH3 pituitary cells
Q42236690A rapid assay for measuring the activity and the Mg2+ and Ca2+ requirements of phosphatidate phosphohydrolase in cytosolic and microsomal fractions of rat liver.
Q41824399A transient increase in diacylglycerols is associated with the action of vasopressin on hepatocytes
Q71836563Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine
Q42862666Biphasic effects of glucagon and cyclic AMP on the synthesis and secretion of lipids by rat hepatocytes
Q72389910CTP:phosphorylcholine cytidylyltransferase in rat lung. The effect of free fatty acids on the translocation of activity between microsomes and cytosol
Q42848021Can phosphorylation of phosphatidate phosphohydrolase by a cyclic AMP-dependent mechanism regulate its activity and subcellular distribution and control hepatic glycerolipid synthesis?
Q42120043Effects of cyclic AMP, glucocorticoids and insulin on the activities of phosphatidate phosphohydrolase, tyrosine aminotransferase and glycerol kinase in isolated rat hepatocytes in relation to the control of triacylglycerol synthesis and gluconeogen
Q38470822Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes.
Q41788761Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes
Q67841210Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a decrease in cellular diacylglycerol levels in cultured rat hepatocytes
Q42818818Hormonal regulation of phosphatidylcholine synthesis by reversible modulation of cytidylyltransferase
Q42066806Interactions of insulin, glucagon and dexamethasone in controlling the activity of glycerol phosphate acyltransferase and the activity and subcellular distribution of phosphatidate phosphohydrolase in cultured rat hepatocytes
Q40081072Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis
Q73942633Lipaemia and liver composition in pregnant rats consuming olive oil and olive oil used for frying
Q72393226Long-chain fatty acids and their acyl-CoA esters cause the translocation of phosphatidate phosphohydrolase from the cytosolic to the microsomal fraction of rat liver
Q40097134Mechanisms of regulation of the partition of fatty acids between oxidation and esterification in the liver
Q41816137Oleic acid promotes the activation and translocation of phosphatidate phosphohydrolase from the cytosol to particulate fractions of isolated rat hepatocytes
Q72392623Phorbol esters stimulate phosphatidylcholine biosynthesis by translocation of CTP: Phosphocholine cytidylyltransferase from cytosol to microsomes
Q42165721Regulation of CTP: phosphocholine cytidylyltransferase activity in type II pneumonocytes
Q42867075Regulation of the translocation of phosphatidate phosphohydrolase between the cytosol and the endoplasmic reticulum of rat liver. Effects of unsaturated fatty acids, spermine, nucleotides, albumin and chlorpromazine
Q38470656Stimulation of sphingomyelin biosynthesis by brefeldin A and sphingomyelin breakdown by okadaic acid treatment of rat hepatocytes
Q41995540The choline-depleted type II pneumonocyte. A model for investigating the synthesis of surfactant lipids
Q41669170The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells
Q42858138The response of adipocyte glucose metabolism and fatty acid release to adenosine deaminase, insulin and perifusion. Investigation of intermediary metabolism by perifusion

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