CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22.

scientific article published on 6 December 2012

CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/JID.2012.456
P932PMC publication ID3835628
P698PubMed publication ID23223131

P50authorDirkjan HijnenQ57025797
Edward Frank KnolQ58454726
P2093author name stringThomas S Kupper
Carla A F M Bruijnzeel-Koomen
Rachael A Clark
Barbara Giovannone
Scott J P Beijn
Yoony Y Gent
P2860cites workSkin-infiltrating CD8+ T cells initiate atopic dermatitis lesionsQ80178370
Modulation of keratinocyte-derived MMP-9 by IL-13: a possible role for the pathogenesis of epidermal inflammationQ80540782
IL-13-stimulated human keratinocytes preferentially attract CD4+CCR4+ T cells: possible role in atopic dermatitisQ82584169
CD8+ T cells are recruited early to allergen exposure sites in atopy patch test reactions in human atopic dermatitisQ83209169
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptidesQ24303817
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodelingQ24647357
IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cellsQ33869215
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitutionQ34440722
Resolved psoriasis lesions retain expression of a subset of disease-related genesQ34490905
Tight junction defects in patients with atopic dermatitis.Q34629278
Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalitiesQ35084580
Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytesQ35106151
Cytokine modulation of atopic dermatitis filaggrin skin expressionQ37159649
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasisQ37179608
T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitisQ37527634
Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A productionQ37562266
Contrasting pathogenesis of atopic dermatitis and psoriasis--part II: immune cell subsets and therapeutic conceptsQ37855007
IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytesQ38329713
Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiationQ39995471
Endogenous antimicrobial peptides and skin infections in atopic dermatitisQ40698186
Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodelingQ43183078
Relative importance of IL-4 and IL-13 in lesional skin of atopic dermatitisQ44795743
Atopy patch test with house dust mite allergen--an IgE-mediated reaction?Q47257080
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.Q51974034
A novel method for the isolation of skin resident T cells from normal and diseased human skin.Q51984689
PsoriasisQ56115292
T Cells and T Cell-Derived Cytokines as Pathogenic Factors in the Nonallergic Form of Atopic DermatitisQ61959858
The structure of normal skin and the morphology of atopic eczemaQ67816093
Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical studyQ71038378
In vivo expression of IL-12 and IL-13 in atopic dermatitisQ71423348
Analysis of the Cytokine Pattern Expressed In Situ in Inhalant Allergen Patch Test Reactions of Atopic Dermatitis PatientsQ72037404
Lesional expression of interferon-gamma in atopic eczemaQ72665549
IL-13 over-expression in skin is not confined to IgE-mediated skin inflammationQ73781457
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectatopic dermatitisQ268667
P304page(s)973-979
P577publication date2012-12-06
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleCD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22
P478volume133

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