The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status

scientific article published on September 2010

The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1029684976
P356DOI10.1038/EJCN.2010.157
P698PubMed publication ID20808328

P50authorAnna Stanisławska-SachadynQ64495506
P2093author name stringA S Whitehead
A E Evans
I S Young
C M Sayers
J V Woodside
J W Yarnell
L E Mitchell
P2860cites workMaternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortificationQ22336986
Structural basis for mammalian vitamin B12 transport by transcobalaminQ24307771
Vitamin B12 deficiency in the elderlyQ28142240
The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer diseaseQ28645892
Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in bloodQ31835230
Receptor-mediated endocytosis of cobalamin (vitamin B12).Q33711784
Cellular import of cobalamin (Vitamin B-12).Q33739202
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysisQ34160359
Significance of elevated cobalamin (vitamin B12) levels in bloodQ34278946
Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolismQ34424582
The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with diseaseQ34526501
Folic acid and homocysteine in age-related diseaseQ34662356
In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrationsQ36289002
The many facets of hyperhomocysteinemia: studies from the Framingham cohortsQ36479637
Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).Q37340010
Polymorphism of human transcobalamin II: substitution of proline and/or glutamine residues by arginineQ41435292
THE METHYL FOLATE TRAP A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemiaQ42241278
Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.Q43411557
Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adultsQ44045933
Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defectsQ44055759
The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortionQ44232617
Analysis of the transcobalamin II 776C>G (259P>R) single nucleotide polymorphism by denaturing HPLC in healthy elderly: associations with cobalamin, homocysteine and holo-transcobalamin II.Q44680024
Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adultsQ46765955
Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease.Q52552984
High prevalence of cobalamin deficiency in elderly outpatientsQ67590422
Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serumQ67947806
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemiaQ71816122
Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trialQ74535182
776C>G polymorphism of the transcobalamin II gene as a risk factor for spina bifidaQ75184763
Isoelectrofocusing phenotype and relative concentration of transcobalamin II isoproteins related to the codon 259 Arg/Pro polymorphismQ77472248
Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy childrenQ79838046
Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolismQ80162829
P433issue11
P921main subjectvitamin BQ183206
P304page(s)1338-1343
P577publication date2010-09-01
P1433published inEuropean Journal of Clinical NutritionQ15756702
P1476titleThe transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status
P478volume64

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cites work (P2860)
Q30279068A Fast Multiple-Kernel Method With Applications to Detect Gene-Environment Interaction
Q50256416An update on vitamin B12-related gene polymorphisms and B12 status
Q49624087Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population
Q47944759Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies
Q36419151Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma
Q40193336Association of ulcerative colitis with transcobalamin II gene polymorphisms and serum homocysteine, vitamin B12, and folate levels in Chinese patients
Q37517155Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor
Q91567815Homologous G776G Variant of Transcobalamin-II Gene is Linked to Vitamin B12 Deficiency
Q46053162Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake
Q57677507Transcobalamin Polymorphism 67A->G, but Not 776C->G, Affects Serum Holotranscobalamin in a Cohort of Healthy Middle-Aged Men and Women
Q47137849Transcriptional changes in mesenteric and subcutaneous adipose tissue from Holstein cows in response to plane of dietary energy

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