Thymosin alpha 1: biological activities, applications and genetic engineering production

scientific article published on 10 August 2010

Thymosin alpha 1: biological activities, applications and genetic engineering production is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.PEPTIDES.2010.07.026
P698PubMed publication ID20699109

P2093author name stringJuan Li
Chun Hui Liu
Feng Shan Wang
P2860cites workPeginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infectionQ27860901
Thymosin alpha1: a historical overviewQ28306139
History of the discovery of the thymosinsQ28307864
Incidence of hepatocellular carcinoma among individuals with hepatitis B virus infection identified using an automated data algorithm.Q31140382
Evaluation of efficacy of thymosin alpha1 in the treatment of sepsis: a systematic reviewQ33399635
Potential Role of Thymosin-alpha1 Adjuvant Therapy for GlioblastomaQ33606685
Cellular immune responses to HIV.Q34223069
Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathwayQ34360330
Expression of heterologous proteins in Pichia pastoris: a useful experimental tool in protein engineering and productionQ34371501
Cloning and nucleotide sequencing of the genes rimI and rimJ which encode enzymes acetylating ribosomal proteins S18 and S5 of Escherichia coli K12.Q34553172
Thymosin alpha 1: from bench to bedsideQ34643499
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptideQ34674378
Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cellsQ34806635
Thymosin alpha(1) in combination with cytokines and chemotherapy for the treatment of cancer.Q35177560
Thymosins: chemistry and biological properties in health and diseaseQ35753541
Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytesQ36003011
Roles of thymosins in cancers and other organ systemsQ36038461
The peptide molecular links between the central nervous and the immune systems.Q36214181
Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum levelQ46967712
Construction and application of a yeast expression system for thymosin alpha1.Q46980635
Thymosin alpha(1) application augments immune response and down-regulates tumor weight and organ colonization in BALB/c-miceQ47230335
Production of biologically active N alpha-desacetylthymosin alpha 1 in Escherichia coli through expression of a chemically synthesized geneQ48411482
Studies of therapy with thymosin alpha1 in combination with pegylated interferon alpha2a and ribavirin in nonresponder patients with chronic hepatitis C.Q50571453
Construction and expression of a new fusion protein, thymosin alpha1-cBLyS, E. coli.Q51539604
Thymosin alpha1 as a chemopreventive agent in lung and breast cancer.Q51750277
Immunopharmacology of thymosin alpha1 and cytokine synergy.Q53568419
Solid-phase synthesis of thymosin alpha 1 using tert-butyloxycarbonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-resin.Q54543459
Thymosin 1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and toleranceQ58855391
From lab to bedside: emerging clinical applications of thymosin α1Q61160529
Thymosin alpha 1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytesQ68708462
A randomized trial to evaluate the immunorestorative properties of synthetic thymosin-alpha 1 in patients with lung cancerQ70113575
Automated solid phase synthesis of thymosin alpha 1Q71142800
Biochemotherapy with thymosin alpha 1, interleukin-2 and dacarbazine in patients with metastatic melanoma: clinical and immunological effectsQ72422185
Thymosin alpha 1 stimulates endothelial cell migration, angiogenesis, and wound healingQ74463532
Immunoregulation of thymosin alpha 1 treatment of cytomegalovirus infection accompanied with acute respiratory distress syndrome after renal transplantationQ79715606
[A clinical study of thymosin alpha1 as an auxiliary in treating spontaneous peritonitis in patients with liver cirrhosis]Q80095979
Liposomal plasmid DNA encoding human thymosin alpha and interferon omega potently inhibits liver tumor growth in ICR miceQ80157904
Signaling pathways leading to the activation of IKK and MAPK by thymosin alpha1Q80475450
[Primary assessment of treatment effect of thymosin alpha1 on chemotherapy-induced neurotoxicity]Q81064301
Thymosin alpha1: a promising molecule for important clinical applicationsQ83777646
Thymalfasin for the treatment of chronic hepatitis C infectionQ36322104
Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin)Q36381898
Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systemsQ36514863
Expression and hydroxylamine cleavage of thymosin alpha 1 concatemerQ36772403
Thymosin alpha1: an endogenous regulator of inflammation, immunity, and toleranceQ36818200
Treatment with lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B patients: a meta-analysisQ37218889
A randomized controlled trial of thymalfasin plus transarterial chemoembolization for unresectable hepatocellular carcinomaQ37356797
Thymic involution and immune reconstitution.Q37361275
Production of recombinant proteins by microbes and higher organismsQ37509309
Combination therapy of thymosin alpha-1 and lamivudine for HBeAg positive chronic hepatitis B: A prospective randomized, comparative pilot studyQ38501403
Suppression of a cold-sensitive mutation in ribosomal protein S5 reveals a role for RimJ in ribosome biogenesisQ39597324
Proliferative and anti-proliferative effects of thymosin alpha1 on cells are associated with manipulation of cellular ROS levels.Q39851472
Expression of thymosin alpha1 concatemer in transgenic tomato (Solanum lycopersicum) fruitsQ40054459
The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymusQ40204323
Expression and analysis of thymosin alpha1 concatemer in Escherichia coliQ40210028
Thymopentin (TP5), an immunomodulatory peptide, suppresses proliferation and induces differentiation in HL-60 cellsQ40235827
Purification and properties of bovine thymosinQ40319653
Combination therapy of thymalfasin (thymosin-alpha 1) and peginterferon alfa-2a in patients with chronic hepatitis C virus infection who are non-responders to standard treatment.Q40455639
Clinical investigation of outbreak of nosocomial severe acute respiratory syndromeQ40555725
T-lymphocyte maturation: cell surface markers and immune function induced by T-lymphocyte cell-free products and thymosin polypeptidesQ40734718
Thymosin-alpha1 regulates MHC class I expression in FRTL-5 cells at transcriptional levelQ40890526
Thymosin fraction 5 inhibits the proliferation of the rat neuroendocrine MMQ pituitary adenoma and C6 glioma cell lines in vitroQ41053105
Short in vitro half-life of thymopoietin32--36 pentapeptide in human plasmaQ41170034
Reviews for APASL guidelines: immunomodulator therapy of chronic hepatitis B.Q42590869
A double-blind, placebo-controlled, pilot trial of thymosin alpha 1 for the treatment of chronic hepatitis C.Q42979415
Thymosin-alpha 1 plus interferon-alpha for naive patients with chronic hepatitis C: results of a randomized controlled pilot trialQ42982620
Efficacy of triple therapy with thymalfasin, peginterferon alpha-2a, and ribavirin for the treatment of hispanic chronic HCV nonrespondersQ42983344
Production of thymosin alpha1 via non-enzymatic acetylation of the recombinant precursorQ43090553
Construction, expression and characterization of human interferon alpha2b-(G4S)n-thymosin alpha1 fusion proteins in Pichia pastorisQ43118529
Optimized Fmoc solid-phase synthesis of Thymosin alpha1 by side-chain anchoring onto a PEG resinQ43267292
Involvement of mitogen-activated protein kinases in the signal transduction pathway of bone marrow-derived macrophage activation in response to in vitro treatment with thymosin alpha 1.Q43853516
Thymosin alpha1 inhibits mammary carcinogenesis in Fisher ratsQ44041777
Thymosin alpha-1 modulates excitatory synaptic transmission in cultured hippocampal neurons in ratsQ44583608
A pilot study of the safety and efficacy of thymosin alpha 1 in augmenting immune reconstitution in HIV-infected patients with low CD4 counts taking highly active antiretroviral therapyQ44665386
Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signalingQ44776004
Induction of immune responses to a human immunodeficiency virus type 1 epitope by novel chimeric influenza viruses.Q45207937
Overexpression of soluble human thymosin alpha 1 in Escherichia coliQ45247121
Combination treatment with zidovudine, thymosin alpha 1 and interferon-alpha in human immunodeficiency virus infectionQ45783241
[High expression of thymosin alpha 1 by injecting recombinant PVX vector into the tomato fruit].Q45917761
The rapidly expanding therapeutic role of thymosin alpha-1 in the management of gastrointestinal and systemic infectious disorders.Q46001736
Intraperitoneal co-administration of thymosin alpha-1 ameliorates streptozotocin-induced pancreatic lesions and diabetes in C57BL/6 miceQ46054423
RimJ is responsible for N(alpha)-acetylation of thymosin alpha1 in Escherichia coliQ46057586
A new immunomodulatory therapy for severe sepsis: Ulinastatin Plus Thymosin {alpha} 1.Q46122546
Expression of thymosin alpha1-thymopentin fusion peptide in Pichia pastoris and its characterizationQ46235139
Expression and activity analysis of interferonalpha-con and thymosin-alpha1Q46330227
A randomized, controlled, clinical study of thymosin alpha-1 versus interferon-alpha in [corrected] patients with chronic hepatitis B lacking HBeAg in China [corrected].Q46369277
The efficacy and safety of thymosin alpha-1 in Japanese patients with chronic hepatitis B; results from a randomized clinical trialQ46454512
Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in ratsQ46483116
P433issue11
P1104number of pages8
P304page(s)2151-2158
P577publication date2010-08-10
P1433published inPeptidesQ7166533
P1476titleThymosin alpha 1: biological activities, applications and genetic engineering production
P478volume31

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cites work (P2860)
Q52649899A novel mechanism of tumor-induced thymic atrophy in mice bearing H22 hepatocellular carcinoma.
Q58566649Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation
Q34300980Complexes of an alpha thymosin derivative with ¹⁸⁵/¹⁸⁷Re and (⁹⁹m)Tc: structural analysis and initial biological evaluation.
Q47200918Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1.
Q47594117Immune regulation effect of lienal polypeptides extract in Lewis lung carcinoma-bearing mice treated with cyclophosphamide.
Q39014494Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Q95281797Modified Thymosin Alpha 1 Distributes and Inhibits the Growth of Lung Cancer in Vivo
Q38747732Peptide-Based and Polypeptide-Based Gene Delivery Systems
Q38891837Pharmacological interventions for acute hepatitis B infection: an attempted network meta-analysis.
Q24186837Pharmacological treatments for acute hepatitis B infection: a network meta-analysis
Q24186878Pharmacological treatments for chronic hepatitis B liver disease: a network meta-analysis
Q58694411Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3–MMP2 signaling

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