V(D)J recombination in peritoneal B cells of leaky scid mice

scientific article published on December 1993

V(D)J recombination in peritoneal B cells of leaky scid mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.178.6.1981
P932PMC publication ID2191267
P698PubMed publication ID8245777

P2093author name stringM J Bosma
D B Kotloff
N R Ruetsch
P2860cites workProgenitors for Ly-1 B cells are distinct from progenitors for other B cellsQ24683187
A severe combined immunodeficiency mutation in the mouseQ28274531
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joinsQ33560933
T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitorsQ33565037
Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animalsQ33652325
Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generationQ33764048
Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus.Q33840975
Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virusQ33847682
Cmu gene rearrangement of mouse immunoglobulin genes in normal B cells occurs on both the expressed and nonexpressed chromosomesQ35310639
Characteristics and development of the murine B-1b (Ly-1 B sister) cell populationQ35320836
Developmental origins, specificities and immunoglobulin gene biases of murine Ly-1 B cellsQ36196169
Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiencyQ36229758
CD3+ T-cells in severe combined immunodeficiency (scid) mice III. Transferred congenic, selfreactive CD4+T cell clones rescue IgM-producing, Scid-derived B cellsQ67903010
Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding jointsQ67914680
An embryonic source of Ly1 but not conventional B cellsQ68315043
Occurrence of mature B (IgM+, B220+) and T (CD3+) lymphocytes in scid miceQ69083418
Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcriptionQ69230362
Limited clonal diversity of serum immunoglobulin in leaky scid miceQ69242605
Mouse Vk gene classification by nucleic acid sequence similarityQ69376859
Only DFL16, DSP2, and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which DFL16 and DSP2 originate from the same primordial DH geneQ69384748
Pauciclonal B cell involvement in production of immunoglobulin in scid Ig+ miceQ69779862
Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineageQ70309067
The Ly-1 B cell lineageQ70312538
High connectivity, natural antibodies preferentially use 7183 and QUPC 52 VH familiesQ70336375
Novel strand exchanges in V(D)J recombinationQ70414763
5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strainsQ71520598
T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertionQ36230427
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusionsQ36302303
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segmentsQ36346092
Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid miceQ36351283
Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequencesQ36353825
Evidence of functional lymphocytes in some (leaky) scid miceQ36354631
Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversityQ36356579
Restricted immunoglobulin junctional diversity in neonatal B cells results from developmental selection rather than homology-based V(D)J joiningQ36361212
Ordered rearrangement of immunoglobulin heavy chain variable region segmentsQ36586574
Wild-type V(D)J recombination in scid pre-B cellsQ36728878
The response of human platelets to activated components of the complement systemQ36845198
Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reactionQ36901365
Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell developmentQ37156784
A developmental switch in B lymphopoiesisQ37652961
Influence of a V kappa 8 L chain transgene on endogenous rearrangements and the immune response to the HA(Sb) determinant on influenza virusQ38333358
Regulation of the assembly and expression of variable-region genesQ39588958
Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage?Q39647319
Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.Q41123945
Detection and characterization of functional T cells in mice with severe combined immune deficiencyQ41338064
Extent to which homology can constrain coding exon junctional diversity in V(D)J recombinationQ41547272
Scid mouse Pre-B cells with intracellular mu chains: analysis of recombinase activity and IgH gene rearrangementsQ41561092
Analysis of the defect in DNA end joining in the murine scid mutationQ41600489
Ig H and L chain contributions to autoimmune specificitiesQ42623521
B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading framesQ42627426
VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodiesQ42800146
A better cell line for making hybridomas secreting specific antibodiesQ42802415
Similarities in B cell repertoire development between autoimmune and aging normal miceQ44264616
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signalsQ45246384
Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphomaQ46813357
Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joiningQ46849388
Polyreactive IgM antibodies generated from autoimmune mice and selected for histone-binding activityQ48154155
Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segmentsQ48302044
Unusual immunoglobulin gene rearrangement leads to replacement of recombinational signal sequencesQ48313396
The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombinationQ48313594
Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.Q52244112
A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.Q52260647
Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequences.Q52885348
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.Q53534567
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell developmentQ57339980
T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genesQ57557410
Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epitheliaQ59048991
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expressionQ59085816
V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signalsQ64389915
DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genesQ67285091
V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytesQ67521111
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1981-1994
P577publication date1993-12-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleV(D)J recombination in peritoneal B cells of leaky scid mice
P478volume178

Reverse relations

cites work (P2860)
Q52082343A mathematical model predicting the frequency of aberrant rearrangements in the T-cell receptor gene.
Q36656452Abnormal deletions in the T-cell receptor delta locus of mouse thymocytes
Q77711593Age-dependent increase of peritoneal B-1b B cells in SCID mice
Q37689611Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires
Q39620303Development of a murine model of lymph node metastases suitable for immunotoxicity studies
Q33702830Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.
Q41919588Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System
Q91272449Immune-relevant aspects of murine models of head and neck cancer
Q28247264The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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