Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis

scientific article published on January 2002

Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20011022
P932PMC publication ID2193607
P698PubMed publication ID11805151
P5875ResearchGate publication ID11554280

P50authorPeter LibbyQ22670611
P2093author name stringNorbert Gerdes
James L Young
Galina K Sukhova
Uwe Schönbeck
Rebecca S Reynolds
P2860cites workCloning of a novel receptor subunit, AcPL, required for interleukin-18 signalingQ22004163
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Interleukin-18Q73092329
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Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient miceQ74270371
Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaquesQ77756578
IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 familyQ77807763
IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responsesQ77899699
Purification and characterization of the human interleukin-18 receptorQ24316885
Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma productionQ24317305
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Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the proteinQ28118154
Cloning of a new cytokine that induces IFN-gamma production by T cellsQ28283928
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptorQ28507342
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzymeQ28610362
A proinflammatory role for IL-18 in rheumatoid arthritisQ33902122
Interleukin 18: a pleiotropic participant in chronic inflammation.Q33953165
Interleukin-18 regulates both Th1 and Th2 responsesQ34178165
Immune interferon inhibits proliferation and induces 2'-5'-oligoadenylate synthetase gene expression in human vascular smooth muscle cellsQ34570163
Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosisQ34627050
Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-gamma knockout recipientsQ35763743
Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzymeQ35796049
Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cellsQ36356932
Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivoQ36367835
Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formationQ36377004
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cellsQ37179132
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IFN-gamma potentiates atherosclerosis in ApoE knock-out miceQ37368296
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Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cellsQ37378111
Role of interferon-gamma in immune cell regulation.Q40414843
Expression and responsiveness of human interleukin-18 receptor (IL-18R) on hematopoietic cell linesQ40871919
Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells.Q41001482
Interleukin-18/interferon-gamma-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cellsQ41003824
Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.Q41103068
Expression of tumour necrosis factor-alpha, -beta and interferon-gamma genes within human neuroglial tumour cells and brain specimensQ41484463
Interferon-gamma gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulationQ41612397
Interferon gamma upregulates its own gene expression in mouse peritoneal macrophages.Q41859942
Response of resting human peripheral blood natural killer cells to interleukin 2.Q42153962
Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- miceQ42757050
Defective NK cell activity and Th1 response in IL-18-deficient miceQ43595287
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.Q45933733
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.Q50335883
Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque InstabilityQ58150063
Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and StabilityQ58150092
Interferon-γ elicits arteriosclerosis in the absence of leukocytesQ59064332
Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokinesQ60746676
Interleukin-10 blocks atherosclerotic events in vitro and in vivoQ64381132
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
interleukinsQ194908
P304page(s)245-257
P577publication date2002-01-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleExpression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis
P478volume195