Thermodynamic mixing of molecular states of the epidermal growth factor receptor modulates macroscopic ligand binding affinity

scientific article published in November 2000

Thermodynamic mixing of molecular states of the epidermal growth factor receptor modulates macroscopic ligand binding affinity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/0264-6021:3520099
P932PMC publication ID1221436
P698PubMed publication ID11062062
P5875ResearchGate publication ID12264989

P2093author name stringGross DJ
Slakey LL
Holbrook MR
P2860cites workFunctional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulationQ24339590
The EGF receptor is an actin-binding proteinQ24642959
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substratesQ28624927
Dynamin, endocytosis and intracellular signalling (review).Q30176794
Two EGF molecules contribute additively to stabilization of the EGFR dimerQ33885990
Heterogeneity of epidermal growth factor binding kinetics on individual cellsQ33907276
Implications of epidermal growth factor (EGF) induced egf receptor aggregationQ34091453
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic systemQ36219234
High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responsesQ36222608
Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibodyQ37605237
Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motifQ38356797
Molecular analysis of signal transduction by growth factorsQ39650738
Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.Q41161959
Reconstitution of epidermal growth factor receptor transmodulation by platelet-derived growth factor in Chinese hamster ovary cellsQ41271521
Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activityQ41437650
Epidermal growth factor receptors associated to cytoskeletal elements of epidermoid carcinoma (A431) cellsQ41484044
Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptorsQ41527421
Properties of a monoclonal antibody to epidermal growth factor receptor with implications for the mechanism of action of EGFQ41570117
Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptorsQ41590853
Identification of an intracellular domain of the EGF receptor required for high-affinity binding of EGF.Q42799379
Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factorQ42829115
A unified model of c-erbB receptor homo- and heterodimerisationQ47864308
High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A).Q47922023
Epidermal growth factor receptor binding is not a simple one-step process.Q52517574
Interaction of Epidermal growth factor receptors with the cytoskeleton is related to receptor clusteringQ58280939
Three classes of epidermal growth factor receptors on HeLa cellsQ68179828
Ligand-induced association of epidermal growth factor receptor to the cytoskeleton of A431 cellsQ69613282
Characterization of the epidermal growth factor receptor associated with cytoskeletons of A431 cellsQ69652465
Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cellsQ70146276
Epidermal growth factor receptor internalization rate is regulated by negative charges near the SH2 binding site Tyr992Q78021407
P407language of work or nameEnglishQ1860
P921main subjectligand bindingQ61659151
P304page(s)99-108
P577publication date2000-11-01
P1433published inBiochemical JournalQ864221
P1476titleThermodynamic mixing of molecular states of the epidermal growth factor receptor modulates macroscopic ligand binding affinity
P478volume352 Pt 1