Death switch for gene therapy: application to erythropoietin transgene expression

scientific article published on 21 May 2010

Death switch for gene therapy: application to erythropoietin transgene expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1590/S0100-879X2010007500046
P698PubMed publication ID20499015

P2093author name stringD M Spencer
F F Costa
E Payen
Y Beuzard
H F Carvalho
D S Souza
M A Salomão
S T Olalla Saad
T S I Salles
P2860cites workRedesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificityQ27765263
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune responseQ29619095
A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic miceQ34135412
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.Q34168942
Myoblast transfer of human erythropoietin gene in a mouse model of renal failureQ34210746
Pharmacologically regulated cell therapyQ34225667
Controlling Signal Transduction with Synthetic LigandsQ34306937
High-efficiency gene transfer into skeletal muscle mediated by electric pulsesQ35123357
Clinical gene transfer studies for hemophilia A.Q35760801
Synthetic activation of caspases: artificial death switchesQ36007918
Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virusQ39685864
Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice.Q40689739
Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapyQ40703087
Ablation of microvessels in vivo upon dimerization of iCaspase-9.Q40739616
Improved artificial death switches based on caspases and FADD.Q40924176
Improvement of mouse beta-thalassemia upon erythropoietin delivery by encapsulated myoblastsQ40937517
Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblastsQ40954676
Functional analysis of Fas signaling in vivo using synthetic inducers of dimerizationQ41187958
An inducible caspase 9 safety switch for T-cell therapyQ41768001
Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblastsQ42524485
Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivoQ43627722
Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer.Q43727676
Oxygen tension and a pharmacological switch in the regulation of transgene expression for gene therapyQ43767321
Human erythropoietin gene therapy for patients with chronic renal failureQ45044565
Erythropoietin gene therapy leads to autoimmune anemia in macaquesQ45871284
Autoimmune anemia in macaques following erythropoietin gene therapyQ45871935
Antiangiogenic gene therapy: disruption of neovascular networks mediated by inducible caspase-9 delivered with a transcriptionally targeted adenoviral vectorQ45880251
A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tensionQ45884448
Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF.Q46445961
Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model.Q47438492
Improvement of mouse beta-thalassemia by electrotransfer of erythropoietin cDNA.Q57670350
Gene Electrotransfer Results in a High-Level Transduction of Rat Skeletal Muscle and Corrects Anemia of Renal FailureQ58535589
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecterythropoietinQ218706
gene therapyQ213901
P304page(s)634-644
P577publication date2010-05-21
P1433published inBrazilian Journal of Medical and Biological ResearchQ2025772
P1476titleDeath switch for gene therapy: application to erythropoietin transgene expression
P478volume43

Reverse relations

cites work (P2860)
Q35238279Safeguarding nonhuman primate iPS cells with suicide genes.
Q37041259Switchable elastin-like polypeptides that respond to chemical inducers of dimerization
Q38848128The potential of genetically guided treatment in Behçet's disease

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