Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans

scientific article published on 19 June 2009

Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/EC.00081-09
P932PMC publication ID2725568
P698PubMed publication ID19542310

P50authorElvira RománQ91299010
P2093author name stringFabien Cottier
Joachim F Ernst
Jesús Pla
P2860cites workActivation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulatorQ24533167
Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathwayQ27930285
Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.Q27930567
Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.Q27930940
Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.Q27930943
Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeastQ27931132
Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressureQ27931203
Loss of the plasma membrane-bound protein Gas1p in Saccharomyces cerevisiae results in the release of beta1,3-glucan into the medium and induces a compensation mechanism to ensure cell wall integrity.Q27931335
Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.Q27932838
Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeastQ27933289
Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeastQ27933488
Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathwayQ27934048
A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branchQ27934962
The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiaeQ27936490
Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RASQ27936756
A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeastQ27938083
The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.Q27939105
Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiaeQ27939128
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarityQ27939243
Optimization of specificity in a cellular protein interaction network by negative selectionQ27940190
Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5Q28205819
Osmotic stress signaling and osmoadaptation in yeastsQ29617597
Nonfilamentous C. albicans mutants are avirulentQ29617839
Stimulation of chitin synthesis rescues Candida albicans from echinocandins.Q33326983
Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasisQ33754752
The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7pQ33890139
CDC42 is required for polarized growth in human pathogen Candida albicans.Q33905537
A contact-activated kinase signals Candida albicans invasive growth and biofilm developmentQ33936541
Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.Q33937171
A cytoplasmic coiled-coil domain is required for histidine kinase activity of the yeast osmosensor, SLN1.Q33941413
Isogenic strain construction and gene mapping in Candida albicans.Q33961115
Transcription factors in Candida albicans - environmental control of morphogenesisQ33994829
Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p.Q34005397
Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transitionQ34167828
Candida albicans proteinases: resolving the mystery of a gene familyQ34331590
Yeast go the whole HOG for the hyperosmotic responseQ34762154
Dealing with osmostress through MAP kinase activation.Q34768942
Caspofungin: first approved agent in a new class of antifungalsQ35124726
Adaptation of Candida albicans to the host environment: the role of morphogenesis in virulence and survival in mammalian hostsQ35206887
Caspofungin: the first in a new class of antifungal agentsQ35214623
Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesisQ35567860
Immunity to fungal infectionsQ35602207
Morphogenesis in Candida albicansQ35674379
Targeted gene deletion in Candida albicans wild-type strains by MPAR flipping.Q53857157
PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.Q53873705
Transcriptional and physiological adaptation to defective protein-O-mannosylation in Candida albicansQ57216656
Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genesQ58450777
Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutationsQ70409691
Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 geneQ73189498
A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicansQ74285641
Transcriptional response of Candida albicans to hypoxia: linkage of oxygen sensing and Efg1p-regulatory networksQ79947349
Transcript profiling of a MAP kinase pathway in C. albicansQ81242440
Candida albicans proteinases and host/pathogen interactionsQ35875741
Candida morphogenesis and host-pathogen interactionsQ35883023
APSES proteins regulate morphogenesis and metabolism in Candida albicansQ35918681
Morphogenesis beyond cytokinetic arrest in Saccharomyces cerevisiae.Q36255970
Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stressQ36370450
Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infectionQ36370514
The MAP kinase signal transduction network in Candida albicans.Q36426498
Emerging echinocandins for treatment of invasive fungal infectionsQ36458402
Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatusQ36482511
Macrophages in resistance to candidiasisQ36574240
Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicansQ36690032
Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal developmentQ36690106
Regulation of the Candida albicans cell wall damage response by transcription factor Sko1 and PAS kinase Psk1Q36739864
MAP kinase pathways as regulators of fungal virulence.Q36744740
Cloning, analysis and one-step disruption of the ARG5,6 gene of Candida albicansQ36847702
Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicansQ36948102
The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathwayQ38345649
Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicansQ39495714
Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans.Q39513957
The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans.Q39751926
The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicansQ39843038
The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans.Q39890876
Effect of Calcofluor white and Congo red on fungal cell wall morphogenesis: in vivo activation of chitin polymerization.Q39981339
Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrityQ40016068
Differential susceptibility of mitogen-activated protein kinase pathway mutants to oxidative-mediated killing by phagocytes in the fungal pathogen Candida albicansQ40161812
Comparative analysis of HOG pathway proteins to generate hypotheses for functional analysisQ40351909
Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophilsQ40994885
Genome-wide analysis of the response to protein glycosylation deficiency in yeastQ41250465
Two adjacent docking sites in the yeast Hog1 mitogen-activated protein (MAP) kinase differentially interact with the Pbs2 MAP kinase kinase and the Ptp2 protein tyrosine phosphataseQ41772137
The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans.Q41869795
Glycosylation defects activate filamentous growth Kss1 MAPK and inhibit osmoregulatory Hog1 MAPK.Q41920229
Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicansQ42022199
Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungiQ42135090
A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicansQ42629264
Reduced pathogenicity of a Candida albicans MAP kinase phosphatase (CPP1) mutant in the murine mastitis modelQ44545967
The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans.Q46633733
Comparative genomics of the HOG-signalling system in fungiQ46935843
Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4pQ48046730
Suppression of hyphal formation in Candida albicans by mutation of a STE12 homologQ48077116
The SAT1 flipper, an optimized tool for gene disruption in Candida albicansQ48168925
A Ser/Thr-rich multicopy suppressor of a cdc24 bud emergence defectQ48179544
The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans.Q50772221
Mitogen-activated protein kinase-defective Candida albicans is avirulent in a novel model of localized murine candidiasis.Q52531876
Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin.Q52551167
P433issue8
P921main subjectCandida albicansQ310443
P304page(s)1235-1249
P577publication date2009-06-19
P1433published inEukaryotic CellQ5408685
P1476titleMsb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans
P478volume8

Reverse relations

cites work (P2860)
Q35185969A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid medium
Q35018075Activation of the Cph1-dependent MAP kinase signaling pathway induces white-opaque switching in Candida albicans
Q52956290Activation of the signalling mucin MoMsb2 and its functional relationship with Cbp1 in Magnaporthe oryzae.
Q26785119Adaptations of the Secretome of Candida albicans in Response to Host-Related Environmental Conditions
Q43992368Beyond the wall: Candida albicans secret(e)s to survive.
Q35025275Calmodulin binding to Dfi1p promotes invasiveness of Candida albicans
Q35607648Candida albicans Cek1 mitogen-activated protein kinase signaling enhances fungicidal activity of salivary histatin 5
Q39896910Candida albicans beta-glucan exposure is controlled by the fungal CEK1-mediated mitogen-activated protein kinase pathway that modulates immune responses triggered through dectin-1
Q34545173Candida albicans cell-type switching and functional plasticity in the mammalian host
Q42021694Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides.
Q40553730Candida albicans responds to glycostructure damage by Ace2-mediated feedback regulation of Cek1 signaling
Q42944837Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans
Q36729978Cell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host
Q36002683Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance.
Q36001598Comparative Analysis of Transmembrane Regulators of the Filamentous Growth Mitogen-Activated Protein Kinase Pathway Uncovers Functional and Regulatory Differences
Q38930587Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis.
Q51041768Cpp1 phosphatase mediated signaling crosstalk between Hog1 and Cek1 mitogen-activated protein kinases is involved in the phenotypic transition in Candida albicans.
Q42484808Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans
Q38283853Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans
Q64238461Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway
Q33714031Generational distribution of a Candida glabrata population: Resilient old cells prevail, while younger cells dominate in the vulnerable host
Q34098943Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans
Q90148666Lrg1 Regulates β (1,3)-Glucan Masking in Candida albicans through the Cek1 MAP Kinase Pathway
Q35867270Mitochondrial sorting and assembly machinery subunit Sam37 in Candida albicans: insight into the roles of mitochondria in fitness, cell wall integrity, and virulence
Q35056568Morphogenesis-regulated localization of protein kinase A to genomic sites in Candida albicans
Q40812978Msb2 shedding protects Candida albicans against antimicrobial peptides
Q90484097New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond
Q54107588Non-canonical Activities of Hog1 Control Sensitivity of Candida albicans to Killer Toxins From Debaryomyces hansenii.
Q64114524Nutrient and Stress Sensing in Pathogenic Yeasts
Q90375335Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum
Q92800108Protein-Protein Interactions in Candida albicans
Q34190284Regulatory circuitry governing fungal development, drug resistance, and disease.
Q35942002Role of Cln1 during melanization of Cryptococcus neoformans.
Q34471773Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis
Q60046911Sho1 and Msb2 Play Complementary but Distinct Roles in Stress Responses, Sexual Differentiation, and Pathogenicity of
Q43001712Sho1 and Msb2-related proteins regulate appressorium development in the smut fungus Ustilago maydis.
Q97530552Sho1p Connects Glycolysis to Ras1-cAMP Signaling and Is Required for Microcolony Formation in Candida albicans
Q39247266Signaling domains of mucin Msb2 in Candida albicans.
Q42409783Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans
Q46334030Stress Adaptation.
Q38172488Stress adaptation in a pathogenic fungus
Q37719594Stress signalling to fungal stress-activated protein kinase pathways
Q36606833Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans
Q35516184Targeted changes of the cell wall proteome influence Candida albicans ability to form single- and multi-strain biofilms
Q92883935The Aspergillus fumigatus Mucin MsbA Regulates the Cell Wall Integrity Pathway and Controls Recognition of the Fungus by the Immune System
Q37287464The Cek1‑mediated MAP kinase pathway regulates exposure of α‑1,2 and β‑1,2‑mannosides in the cell wall of Candida albicans modulating immune recognition
Q47658898The Mitochondrial GTPase Gem1 Contributes to the Cell Wall Stress Response and Invasive Growth of Candida albicans
Q35703128The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans.
Q36321573The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans
Q46441464The membrane mucin Msb2 regulates invasive growth and plant infection in Fusarium oxysporum
Q37973321The regulation of filamentous growth in yeast
Q51036006The transmembrane protein FgSho1 regulates fungal development and pathogenicity via the MAPK module Ste50-Ste11-Ste7 in Fusarium graminearum.
Q41670314The transmembrane protein Sho1 cooperates with the mucin Msb2 to regulate invasive growth and plant infection in Fusarium oxysporum
Q41113383Unmasking fungal pathogens by studying MAPK-dependent cell wall regulation in Candida albicans