A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor

scientific article published on 26 January 2009

A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/DMD.108.024695
P8608Fatcat IDrelease_ifjvz7dss5fzzep752ibfxmnou
P932PMC publication ID2680541
P698PubMed publication ID19171678
P5875ResearchGate publication ID23950817

P2093author name stringJing Wu
Erin G Schuetz
Taosheng Chen
Rakesh K Tyagi
Satyanarayana R Pondugula
Cynthia Brimer-Cline
P2860cites workPurification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterizationQ40358526
Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition siteQ41541732
Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.Q44550541
Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathwayQ45086569
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Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C.Q45264564
Quantifying effects of ligands on androgen receptor nuclear translocation, intranuclear dynamics, and solubility.Q46914162
Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA.Q47318453
In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulationQ48473453
The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal LectureQ48575949
Negative regulation of the forkhead transcription factor FKHR by Akt.Q52535267
Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.Q52569931
Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.Q52573580
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expressionQ79434234
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactionsQ24310512
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life spanQ24338599
Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalaciaQ24558647
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicityQ24630723
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C diseaseQ24673502
GPS: a comprehensive www server for phosphorylation sites predictionQ24812387
Sequence and characterization of a coactivator for the steroid hormone receptor superfamilyQ27860465
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathwayQ28263744
Modulating nuclear receptor function: may the phos be with youQ33665805
The regulation of protein function by multisite phosphorylation--a 25 year updateQ33928103
Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy?Q34413170
Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor.Q34589569
Steroid receptor phosphorylation: a key modulator of multiple receptor functionsQ34632607
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.Q34732527
Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammationQ34768240
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell linesQ35076110
Nuclear receptors: integration of multiple signalling pathways through phosphorylationQ35078424
Phosphorylation of steroid hormone receptorsQ35957503
The antiapoptotic role of pregnane X receptor in human colon cancer cellsQ36512415
The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncologyQ36798797
Interplay of pregnane X receptor with other nuclear receptors on gene regulationQ37096484
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymesQ37493137
Serine 157, a retinoic acid receptor alpha residue phosphorylated by protein kinase C in vitro, is involved in RXR.RARalpha heterodimerization and transcriptional activityQ38317129
Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).Q38320034
Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerizationQ38329336
Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.Q38337494
Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cellsQ39941217
Human pregnane X receptor and resistance to chemotherapy in prostate cancerQ40059227
Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 geneQ40079327
Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localizationQ40153658
P433issue4
P304page(s)719-730
P577publication date2009-01-26
P1433published inDrug Metabolism and DispositionQ1261140
P1476titleA phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor
P478volume37