In vivo effects of new inhibitors of catechol-O-methyl transferase

scientific article published in April 1999

In vivo effects of new inhibitors of catechol-O-methyl transferase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJP.0702474
P932PMC publication ID1565943
P698PubMed publication ID10323601
P5875ResearchGate publication ID12974291

P2093author name stringE Rivas
O Nieto
J A Fontenla
M L de Ceballos
P2860cites workCatechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patientsQ64891702
Tolcapone improves motor function in parkinsonian patients with the "wearing-off" phenomenon: a double-blind, placebo-controlled, multicenter trialQ64955113
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease.Q67219131
Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's diseaseQ67935479
Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of Parkinson's diseaseQ68003971
Inhibition of catechol-O-methyltransferase by 1-vinyl derivatives of nitrocatechols and nitroguaiacols. Kinetics of the irreversible inhibition by 3-(3-hydroxy-4-methoxy-5-nitro benzylidene)-2,4-pentanedioneQ70764166
Kinetics of the reversible tight-binding inhibition of pig liver catechol-O-methyltransferase by [2-(3,4-dihydroxy-2- nitrophenyl)vinyl]phenyl ketoneQ71694577
Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissuesQ28328872
Behavioural and neurochemical effects of Ro 40-7592, a new COMT inhibitor with a potential therapeutic activity in Parkinson's diseaseQ28334363
Catechol-O-methyl transferase: pharmacological aspects and physiological roleQ34059894
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.Q34168866
Catecholamine metabolism: basic aspects and clinical significance.Q34194962
Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease.Q37941603
Decarboxylase inhibitorsQ40511832
Synthesis of some novel potent and selective catechol O-methyltransferase inhibitorsQ42196980
Randomized, placebo-controlled study of tolcapone in patients with fluctuating Parkinson disease treated with levodopa-carbidopa. Tolcapone Fluctuator Study Group III.Q42540259
Optimizing levodopa pharmacokinetics with multiple tolcapone doses in the elderlyQ42547131
Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the ratQ42711918
Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferaseQ44307365
Modulation of rat brain endogenous dopamine metabolism by new inhibitors of catechol O-methyltransferaseQ48234347
Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacaponeQ48438194
Effect of high single doses of levodopa and carbidopa on brain dopamine and its metabolites: modulation by selective inhibitors of monoamine oxidase and/or catechol-O-methyltransferase in the male rat.Q48647573
3-o-methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathwayQ48912011
Levodopa in Parkinsonism: Potentiation of Central Effects with a Peripheral InhibitorQ51107835
3-Methoxy-4-hydroxyphenylalanine (3-O-methyldopa) in plasma during oral L-dopa therapy of patients with Parkinson's diseaseQ51680487
3-O-Methyldopa, L-dopa, and trihexyphenidyl in the treatment of Parkinson's diseaseQ53835278
Transamination is a Major Pathway of L-Dopa Metabolism following Peripheral Decarboxylase InhibitionQ59081547
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1667-1673
P577publication date1999-04-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleIn vivo effects of new inhibitors of catechol-O-methyl transferase
P478volume126

Reverse relations

cites work (P2860)
Q45387108Antitumor and scavenging radicals activities of some polyphenols related to dehydroabietylamine derivatives
Q36745779Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration
Q48478225Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Q44437032Plasma homovanillic acid: a significant association with alcoholism is independent of a functional polymorphism of the human catechol-O-methyltransferase gene.

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