Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice

scientific article published in February 2006

Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/IAI.74.2.1284-1296.2006
P932PMC publication ID1360368
P698PubMed publication ID16428778
P5875ResearchGate publication ID7343736

P2093author name stringManisha Singh
Hirohito Kita
Chella S David
Govindarajan Rajagopalan
Robin Patel
Koji Iijima
P2860cites workAn outbreak of invasive group A streptococcal disease associated with high carriage rates of the invasive clone among school-aged childrenQ71937759
Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor V beta 3 transgenic miceQ72097798
Induction of acute inflammatory lung injury by staphylococcal enterotoxin BQ73064431
Genotypes and enterotoxicity of Staphylococcus aureus isolated from the hands and nasal cavities of flight-catering employeesQ73193641
Expression and function of HLA-DR3 and DQ8 in transgenic mice lacking functional H2-MQ73732580
Toxic shock syndrome complicating influenza A infection: a two-case report with one case of bacteremia and endocarditisQ73984775
A critical role for mouse CXC chemokine(s) in pulmonary neutrophilia during Th type 1-dependent airway inflammationQ74321590
Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccinesQ74366902
Defense against biologic warfare with superantigen toxinsQ74468468
Expression and function of transgenic HLA-DQ molecules and lymphocyte development in mice lacking invariant chainQ74583224
Interleukin-12 and the development of atopyQ77067418
Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genesQ79253306
Antigen dose, type of antigen-presenting cell and time of differentiation contribute to the T helper 1/T helper 2 polarization of naive T cellsQ79316054
IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heartQ81178240
Antigen presentation and T cell stimulation by dendritic cellsQ22255632
The changing epidemiology of Staphylococcus aureus?Q22305657
Exotoxins of Staphylococcus aureusQ24550718
Prevalence of genes encoding pyrogenic toxin superantigens and exfoliative toxins among strains of Staphylococcus aureus isolated from blood and nasal specimensQ24679713
Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risksQ24683675
Staphylococcus aureus and Wegener's granulomatosisQ24805982
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigenQ27731278
Staphylococcus aureus infectionsQ28131787
Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposisQ28171130
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1Q28271523
Nasal carriage as a source of Staphylococcus aureus bacteremia. Study GroupQ31797996
Functional roles of STAT family proteins: lessons from knockout miceQ33643949
The structural basis of T cell activation by superantigens.Q33652501
HLA class II transgenic mice as models of human diseasesQ33713285
Human leukocyte antigen-DQ8 transgenic mice: a model to examine the toxicity of aerosolized staphylococcal enterotoxin BQ33769260
Immune response to staphylococcal superantigensQ33784073
Longitudinal analysis of the group A Streptococcus transcriptome in experimental pharyngitis in cynomolgus macaquesQ33853470
Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseasesQ33946194
Mucosal tolerance to a bacterial superantigen indicates a novel pathway to prevent toxic shockQ34121640
IL-12/IL-13 axis in allergic asthmaQ34125908
Staphylococcus aureus enterotoxins: a key in airway disease?Q34129972
Group A Streptococcus: allelic variation, population genetics, and host-pathogen interactionsQ34142091
Superantigen-like gene(s) in human pathogenic Streptococcus dysgalactiae, subsp equisimilis: genomic localisation of the gene encoding streptococcal pyrogenic exotoxin G (speG(dys)).Q34154537
The biology of IGE and the basis of allergic diseaseQ34167019
Molecular basis of group A streptococcal virulenceQ34188734
Dendritic cells as regulators of the immune response to inhaled allergen: recent findings in animal models of asthmaQ34243389
New insights into the role of cytokines in asthmaQ34321721
Toxic shock syndrome and bacterial superantigens: an updateQ34360764
Staphylococcus aureus in lower respiratory infections: clinical relevance of antimicrobial resistanceQ34373481
Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agentsQ34385312
Mechanisms for the induction of autoimmunity by infectious agentsQ34402318
What determines nasal carriage of Staphylococcus aureus?Q34453451
The specificity of TCR/pMHC interactionQ34493013
The bidirectional capacity of bacterial antigens to modulate allergy and asthmaQ34529649
Staphylococcus aureus superantigens and airway diseaseQ34579844
Microbiological, biological, and chemical weapons of warfare and terrorismQ34695957
Bacterial and fungal aerosols in indoor environment in Central and Eastern European countries.Q34712351
Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance periodQ34780698
Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situQ34826220
Treatment of community-acquired methicillin-resistant Staphylococcus aureus in childrenQ35160650
Bioterrorism: a new frontier for drug discovery and developmentQ35199198
Bacterial superantigensQ35203877
Superantigens and nasal polyps.Q35553439
Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma arthritidis superantigen MAM.Q35556488
Asthma genetics 2003.Q35649590
New insights into atopic dermatitisQ35678332
Laboratory exposures to staphylococcal enterotoxin BQ35872853
The Staphylococcus aureus "superbug"Q35984316
Staphylococcus aureus decolonizationQ36017707
The role of genetics in the development of asthma and atopyQ36069936
An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposisQ36283543
CpG motifs in bacterial DNA cause inflammation in the lower respiratory tractQ37369552
Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of miceQ39887518
In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonistsQ40204279
HLA class II polymorphisms determine responses to bacterial superantigensQ40597243
Staphylococcal enterotoxin H induces V alpha-specific expansion of T cellsQ40656638
An evolutionary conserved mechanism of T cell activation by microbial toxins. Evidence for different affinities of T cell receptor-toxin interactionQ40755312
Superantigens and their potential role in human diseaseQ40858079
A comparison of the antigen-presenting capabilities of class II MHC-expressing human lung epithelial and endothelial cellsQ41100605
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient miceQ41185362
Mechanisms of pathogenesis of staphylococcal and streptococcal superantigensQ41654405
The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cellsQ42051849
Presence of streptococcal pyrogenic exotoxin A and C genes in human isolates of group G streptococci.Q42594529
Increased T-cell receptor vbeta8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: a potential role for microbial superantigensQ43550805
Antigen concentration determines helper T cell subset participation in IgE antibody responsesQ43636518
Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infectionQ43640551
Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shockQ43891016
Toxic shock syndrome. A newly recognized complication of influenza and influenzalike illnessQ43954059
The significance of nasal carriage of Staphylococcus aureus as risk factor for human skin infectionsQ44006384
Lethal shock induced by streptococcal pyrogenic exotoxin A in mice transgenic for human leukocyte antigen-DQ8 and human CD4 receptors: implications for development of vaccines and therapeuticsQ44113985
Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureusQ44238861
Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic miceQ44448930
Increase in methicillin-resistant Staphylococcus aureus acquisition rate and change in pathogen pattern associated with an outbreak of severe acute respiratory syndromeQ45051242
Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genesQ45198281
The distribution of MHC class I and II antigens on bronchial epitheliumQ46302703
Nasal exposure to Staphylococcal enterotoxin enhances the development of allergic rhinitis in miceQ47812605
Regulation of T helper cell differentiation by STAT moleculesQ47841624
Distribution of virulence genes of Staphylococcus aureus isolated from stable nasal carriersQ47884822
Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humansQ48215207
Increased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD.Q48582525
Summary of the 5th International Conference on Bioaerosols, Fungi, Bacteria, Mycotoxins, and Human Health.Q50746495
Differential presentation of group A streptococcal superantigens by HLA class II DQ and DR alleles.Q50761134
Staphylococcal enterotoxin induced IL-5 stimulation as a cofactor in the pathogenesis of atopic disease: the hygiene hypothesis in reverse?Q51680824
Reduced IL-2-induced IL-12 responsiveness in atopic children.Q52007339
Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice.Q52012264
TSST-1 induces Th1 or Th2 differentiation in naïve CD4+ T cells in a dose- and APC-dependent manner.Q52946372
Airway exposure to bacterial superantigen (SEB) induces lymphocyte-dependent airway inflammation associated with increased airway responsiveness--a model for non-allergic asthma.Q52979791
Diagnostics and treatment of pulmonary BALT lymphoma: a report on four casesQ53653450
Superantigens and chronic rhinosinusitis: detection of staphylococcal exotoxins in nasal polyps.Q53658131
Staphylococcal enterotoxin B-induced activation and concomitant resistance to cell death in CD28-deficient HLA-DQ8 transgenic mice.Q53966216
Relationships between toxin gene content and genetic background in nasal carried isolates of Staphylococcus aureus from Asturias, Spain.Q54682631
Pharyngeal aspiration in normal adults and patients with depressed consciousnessQ55062575
Enhanced Susceptibility to Superantigen‐Associated Streptococcal Sepsis in Human Leukocyte Antigen–DQ Transgenic MiceQ57704227
Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitroQ59078240
High-affinity binding of staphylococcal enterotoxins A and B to HLA-DRQ59078263
Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II moleculesQ68926096
Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class II isotypesQ69406123
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)1284-1296
P577publication date2006-02-01
P1433published inInfection and ImmunityQ6029193
P1476titleIntranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice
P478volume74

Reverse relations

cites work (P2860)
Q54200919A study of the association of childhood asthma with HLA alleles in the population of Siliguri, West Bengal, India.
Q38483892Acute systemic immune activation following conjunctival exposure to staphylococcal enterotoxin B.
Q57157868Childhood asthma and human leukocyte antigen type
Q34079264Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.
Q42534500Chronic exposure to staphylococcal superantigen elicits a systemic inflammatory disease mimicking lupus
Q33585467Cytolysins augment superantigen penetration of stratified mucosa
Q37200625Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor
Q34584576Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia
Q24607551Gram-positive bacterial superantigen outside-in signaling causes toxic shock syndrome
Q30424263HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD
Q38077633Host genotype, intestinal microbiota and inflammatory disorders.
Q35071467Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome
Q36623309Immunopathogenesis of Staphylococcus aureus pulmonary infection.
Q40768885Infection, eosinophilia and childhood asthma
Q36958276Inhalation of Staphylococcus aureus enterotoxin A induces IFN-gamma and CD8 T cell-dependent airway and interstitial lung pathology in mice
Q33815281Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome
Q40759149Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
Q35097527Late multiple organ surge in interferon-regulated target genes characterizes staphylococcal enterotoxin B lethality
Q52632434Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves.
Q42628008Measurement of staphylococcal enterotoxin B in serum and culture supernatant with a capture enzyme-linked immunosorbent assay
Q63976951Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification
Q33877190Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies
Q37165517Rat model of staphylococcal enterotoxin B-induced rhinosinusitis
Q37254793Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge
Q36799764Severity of childhood asthma and human leukocyte antigens type
Q37954310The systemic and pulmonary immune response to staphylococcal enterotoxins
Q47901480Therapeutic blockade of CD54 attenuates pulmonary barrier damage in T cell-induced acute lung injury
Q36221294Trace Levels of Staphylococcal Enterotoxin Bioactivity Are Concealed in a Mucosal Niche during Pulmonary Inflammation

Search more.