| editorial | Q871232 |
| scholarly article | Q13442814 |
| P50 | author | Marcel Leist | Q42136322 |
| P2093 | author name string | Thomas Hartung | |
| P2860 | cites work | Can animal models of disease reliably inform human studies? | Q21563449 |
| Towards tailored assays for cell-based approaches to toxicity testing. | Q51535731 | ||
| Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare. | Q51538339 | ||
| Critical evaluation of the use of dogs in biomedical research and testing in Europe. | Q51846751 | ||
| Preclinical studies of human disease: time to take methodological quality seriously. | Q53083983 | ||
| REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act. | Q53131365 | ||
| The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. | Q53135035 | ||
| Medical progress depends on animal models - doesn't it? | Q55344819 | ||
| Animal models of neurological disease: are there any babies in the bathwater? | Q57278180 | ||
| Animal models: Not close enough | Q59054292 | ||
| Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit | Q70189572 | ||
| Translation of research evidence from animals to humans | Q79220569 | ||
| "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics | Q80819739 | ||
| Systems toxicology | Q84075193 | ||
| Food for Thought ... on mapping the human toxome | Q84229415 | ||
| Publication bias in reports of animal stroke studies leads to major overstatement of efficacy | Q24273209 | ||
| Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research | Q29547313 | ||
| Genomic responses in mouse models poorly mimic human inflammatory diseases | Q29547718 | ||
| 1,026 experimental treatments in acute stroke | Q29615509 | ||
| Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing? | Q30583493 | ||
| Clinical trials for severe sepsis. Past failures, and future hopes | Q33642511 | ||
| Concordance of the toxicity of pharmaceuticals in humans and in animals | Q33921168 | ||
| Neurally mediated airway constriction in human and other species: a comparative study using precision-cut lung slices (PCLS). | Q34443036 | ||
| Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials | Q34617625 | ||
| Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions | Q34770260 | ||
| Toxicology for the twenty-first century | Q34991369 | ||
| Animal models of sepsis: setting the stage | Q36285943 | ||
| The disconnect between animal models of sepsis and human sepsis | Q36614258 | ||
| Distinguishing between mouse and human pluripotent stem cell regulation: the best laid plans of mice and men. | Q37669907 | ||
| Immunomodulatory therapy for sepsis: an update | Q37949639 | ||
| A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. | Q37981574 | ||
| Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test. | Q38105898 | ||
| Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods. | Q39247575 | ||
| Food for thought ... considerations and guidelines for basic test method descriptions in toxicology. | Q39793216 | ||
| The dawning of a new age of toxicology. | Q40081577 | ||
| Food for thought ... on the evolution of toxicology and the phasing out of animal testing | Q46542214 | ||
| Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel | Q46685847 | ||
| Food for thought... on the real success of 3R approaches | Q46687049 | ||
| Food for thought... on animal tests | Q46687051 | ||
| Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature through 1997 and by the National Toxicology Program in 1997-1998. | Q46827417 | ||
| P275 | copyright license | Creative Commons Attribution 2.0 Generic | Q19125117 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 4 | |
| P304 | page(s) | 563-567 | |
| P577 | publication date | 2013-03-19 | |
| P1433 | published in | Archives of Toxicology | Q635837 |
| P1476 | title | Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice | |
| P478 | volume | 87 |
| Q58617836 | 3D Organ Models - Revolution in Pharmacological Research? |
| Q37341837 | A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis. |
| Q23909862 | A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment |
| Q37679858 | Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices |
| Q97073289 | Advancing human health risk assessment |
| Q42307037 | Adverse outcome pathways: opportunities, limitations and open questions |
| Q30358385 | Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing |
| Q38658658 | Central nervous system myeloid cells as drug targets: current status and translational challenges |
| Q40689918 | Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events |
| Q26768698 | Considering new methodologies in strategies for safety assessment of foods and food ingredients |
| Q47985350 | Development of a Perfusion Platform for Dynamic Cultivation of in vitro Skin Models |
| Q28388774 | Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities |
| Q27012682 | Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches |
| Q39820524 | Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro |
| Q38183159 | Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development. |
| Q37578338 | Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay |
| Q86538935 | Food for thought--resveratrol vs. exercise training |
| Q42641582 | From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data |
| Q39658669 | Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue |
| Q43166607 | Highlight report: Interspecies extrapolation by physiologically based pharmacokinetic modeling |
| Q41670160 | In Vitro Evaluation of Glycoengineered RSV-F in the Human Artificial Lymph Node Reactor |
| Q38753758 | In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities |
| Q48722295 | In vitro systems: current limitations and future perspectives |
| Q38269325 | Interspecies extrapolation by physiologically based pharmacokinetic modeling |
| Q33734846 | Mapping the human toxome by systems toxicology. |
| Q59791485 | Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization |
| Q39664131 | Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue |
| Q92345127 | Perspectives on In Vitro to In Vivo Extrapolations |
| Q39156425 | Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production |
| Q34525332 | Primary porcine proximal tubular cells as an alternative to human primary renal cells in vitro: an initial characterization |
| Q36128791 | Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis |
| Q52584444 | Risk Assessment and Risk Minimization in Nanomedicine: A Need for Predictive, Alternative, and 3Rs Strategies. |
| Q35071445 | TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems |
| Q38663718 | The ascendance of microphysiological systems to solve the drug testing dilemma |
| Q38656242 | The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. |
| Q34493876 | The flaws and human harms of animal experimentation |
| Q39509471 | The rat adequately reflects human responses to exercise in blood biochemical profile: a comparative study |
| Q46598911 | The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration |
| Q93077958 | Treatment with Docosahexaenoic Acid Improves Epidermal Keratinocyte Differentiation and Ameliorates Inflammation in Human Keratinocytes and Reconstructed Human Epidermis Models |
| Q88907825 | Validation of in vitro assays in three-dimensional human dermal constructs |
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