Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice

scientific article published in February 2010

Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.23322
P698PubMed publication ID19918973
P5875ResearchGate publication ID38094786

P50authorNaiara BerazaQ50541973
Christian LiedtkeQ53486596
P2093author name stringChristian Trautwein
Darjus F Tschaharganeh
Hermann E Wasmuth
Daniela C Kroy
Leif E Sander
Konrad L Streetz
Arne Giebeler
Stephanie Erschfeld
P2860cites workInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayQ24531184
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouseQ24564225
A central role for JNK in obesity and insulin resistanceQ29619778
Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responsesQ36591648
Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitisQ36669223
Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytesQ36825535
NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetesQ36839912
Identification of a new JNK inhibitor targeting the JNK-JIP interaction siteQ36938538
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistanceQ37038490
Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatmentQ37051418
Liver diseases and metabolic syndromeQ37224466
Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerationsQ37228756
Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver.Q38336686
A stress signaling pathway in adipose tissue regulates hepatic insulin resistanceQ41811449
A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liverQ43722483
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivoQ44723555
Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in miceQ45059652
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.Q45877031
Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitisQ46524814
Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this workQ57339931
Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in miceQ58619570
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic miceQ80809740
Gene expression patterns in hepatic tissue and visceral adipose tissue of patients with non-alcoholic fatty liver diseaseQ81480459
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectsteatosisQ1365091
P304page(s)463-473
P577publication date2010-02-01
P1433published inHepatologyQ15724398
P1476titleLack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice
P478volume51

Reverse relations

cites work (P2860)
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Q27336446Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice
Q35802874Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice
Q35867085Cytokines and STATs in Liver Fibrosis
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