Dasatinib inhibits primary melanoma cell proliferation through morphology-dependent disruption of Src-ERK signaling

scientific article published on 10 December 2012

Dasatinib inhibits primary melanoma cell proliferation through morphology-dependent disruption of Src-ERK signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OL.2012.1066
P932PMC publication ID3573147
P698PubMed publication ID23420605
P5875ResearchGate publication ID235659222

P2093author name stringBo Yu
Bing Su
Jianghong Wu
Xin Liao
P2860cites workDasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemiaQ37044749
Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cellsQ37401245
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Episodic Src activation in uveal melanoma revealed by kinase activity profiling.Q39830805
Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cellsQ39840354
Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitroQ40176252
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cellsQ40366043
The mechanism of cell cycle regulation by v-Src.Q40775817
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entryQ40976467
Microtubule integrity regulates src-like and extracellular signal-regulated kinase activities in human pro-monocytic cells. Importance for interleukin-1 productionQ41062029
Cytoskeleton reorganization induces the urokinase-type plasminogen activator gene via the Ras/extracellular signal-regulated kinase (ERK) signaling pathwayQ41133919
Membrane-microfilament interactions in ascites tumor cell microvilli. Identification and isolation of a large microfilament-associated membrane glycoprotein complex.Q41158644
Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway.Q42819682
Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling.Q43517848
Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiationQ43636975
Role of cell shape in growth controlQ44152787
pp60c‐src mediates ERK activation/nuclear localization and PAI‐1 gene expression in response to cellular deformationQ44409581
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.Q45198729
Inhibition of Mek 1/2 kinase activity and stimulation of melanogenesis by 5,7-dimethoxycoumarin treatment of melanoma cells.Q46020825
Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation.Q52533998
Association of the Ras to mitogen-activated protein kinase signal transduction pathway with microfilaments. Evidence for a p185(neu)-containing cell surface signal transduction particle linking the mitogenic pathway to a membrane-microfilament assocQ78177496
Newest findings on the oldest oncogene; how activated src does itQ24313514
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemiasQ28246193
Actin polymerization is required for negative feedback regulation of epidermal growth factor-induced signal transductionQ32019550
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formationQ33394424
Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.Q33970751
The tyrosine kinase inhibitor dasatinib induces a marked adipogenic differentiation of human multipotent mesenchymal stromal cellsQ34099289
Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemiasQ34335004
Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma.Q34980474
A phase 2 trial of dasatinib in advanced melanomaQ35048145
Role of MAP kinase in tumor progression and invasionQ35186460
Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic TumorigenesisQ36253834
The Src signaling pathway: a potential target in melanoma and other malignanciesQ36675509
Chemotherapy for metastatic melanoma: time for a change?Q36698282
Inhibition of Rho is required for cAMP-induced melanoma cell differentiation.Q36873446
Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell linesQ36940730
P433issue2
P921main subjectdasatinibQ419940
dasatinib monohydrateQ27139135
P304page(s)527-532
P577publication date2012-12-10
P1433published inOncology LettersQ20640514
P1476titleDasatinib inhibits primary melanoma cell proliferation through morphology-dependent disruption of Src-ERK signaling
P478volume5

Reverse relations

Q46739137A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607).cites workP2860